A common IL‐4 receptor variant promotes asthma severity via a T reg cell GRB2‐IL‐6‐Notch4 circuit

A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma

(2020) Hani Harb et al.   NATURE IMMUNOLOGY

Treatment of Severe Persistent Asthma with IL-6 Receptor blockade

(2019) Brittany Esty et al.   Journal of Allergy and Clinical Immunology-In Practice

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

(2019) Michelle Daya et al.   Nature Communications

Environmental exposures and mechanisms in allergy and asthma development

(2019) Liza Bronner Murrison et al.   JOURNAL OF CLINICAL INVESTIGATION

African American ancestry contribution to asthma and atopic dermatitis

(2019) Michelle Daya et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

A Jagged 1–Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles

(2018) Mingcan Xia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children

(2018) Peggy S. Lai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A meta-analysis of genome-wide association studies of asthma in Puerto Ricans

(2017) Qi Yan et al.   EUROPEAN RESPIRATORY JOURNAL

NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management

(2017) Diane R. Gold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes–Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies

(2016) Andreas M. Neophytou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulatory T cells in allergic diseases

(2016) Magali Noval Rivas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells

(2016) Amir Hossein Massoud et al.   NATURE MEDICINE

Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor–notch signaling cascade

(2015) Mingcan Xia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The allergy epidemics: 1870-2010

(2015) Thomas A.E. Platts-Mills   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic

(2015) Corinne A. Keet et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Control of peripheral tolerance by regulatory T cell–intrinsic Notch signaling

(2015) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population

(2014) Rabih Halwani et al.   Annals of Thoracic Medicine

Early-Life Air Pollution and Asthma Risk in Minority Children. The GALA II and SAGE II Studies

(2013) Katherine K. Nishimura et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+signalling

(2011) Jochen A Ackermann et al.   EMBO JOURNAL

The School Inner-City Asthma Study: Design, Methods, and Lessons Learned

(2011) Wanda Phipatanakul et al.   JOURNAL OF ASTHMA

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma

(2011) Manuel AR Ferreira et al.   LANCET

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

(2011) Tomomitsu Hirota et al.   NATURE GENETICS

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

(2009) Raffi Tachdjian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY