The Role of CD4+ T Cells and Microbiota in the Pathogenesis of Asthma

Breastfeeding promotes early neonatal regulatory T cell expansion and immune tolerance of non‐inherited maternal antigens

(2021) HL Wood et al.   ALLERGY

Cytokine Regulation and Function in T Cells

(2021) Chen Dong   Annual Review of Immunology

The basic immunology of asthma

(2021) Hamida Hammad et al.   CELL

The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate

(2021) Holger Garn et al.   Frontiers in Immunology

Clostridium difficile: Diagnosis and the Consequence of Over Diagnosis

(2021) Helen S. Lee et al.   Infectious Diseases and Therapy

Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis

(2021) Jannatul Ferdoush Tuli et al.   ALLERGY

Dysbiosis of the gut and lung microbiome has a role in asthma

(2020) Karin Hufnagl et al.   Seminars in Immunopathology

Lactobacillus reuteri attenuated allergic inflammation induced by HDM in the mouse and modulated gut microbes

(2020) Lingzhi Li et al.   PLoS One

Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

(2020) David M Patrick et al.   Lancet Respiratory Medicine

IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts

(2020) Rakhee K. Ramakrishnan et al.   Frontiers in Immunology

The Controversial Role of Human Gut Lachnospiraceae

(2020) Mirco Vacca et al.   Microorganisms

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease

(2020) Jingyuan Li et al.   MOLECULES

Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

(2020) Shan Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed Establishment of Gut Microbiota in Infants Delivered by Cesarean Section

(2020) Gyungcheon Kim et al.   Frontiers in Microbiology

Associations of Probiotic Fermented Milk (PFM) and Yogurt Consumption with Bifidobacterium and Lactobacillus Components of the Gut Microbiota in Healthy Adults

(2019) Noemí Redondo-Useros et al.   Nutrients

Effect of Lactobacillus rhamnosus GG immunopathologic changes in chronic mouse asthma model

(2019) Chia-Ta Wu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Protease/ anti‐protease network in allergy: the role of S. aureus protease like proteins

(2019) Olga Krysko et al.   ALLERGY

Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma

(2019) M. Demirci et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

The Cytokines of Asthma

(2019) Bart N. Lambrecht et al.   IMMUNITY

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

The Notch signaling pathway promotes basophil responses during helminth-induced type 2 inflammation

(2019) Lauren M. Webb et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota

(2019) Sung-Wook Hong et al.   Science Advances

Mechanisms and therapeutic strategies for Non‐T2 Asthma

(2019) Eric Sze et al.   ALLERGY

Early antibiotic exposure and development of asthma and allergic rhinitis in childhood

(2019) Jeffrey Ni et al.   BMC Pediatrics

Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness

(2019) Mayumi Saeki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysbiosis: from fiction to function

(2019) Connor R Tiffany et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth

(2019) Yan Shao et al.   NATURE

Oral steroids in asthma: a double-edged sword

(2019) Mina Gaga et al.   EUROPEAN RESPIRATORY JOURNAL

Lung Microbiome in Asthma: Current Perspectives

(2019) Konstantinos Loverdos et al.   Journal of Clinical Medicine

Asthma biologics

(2019) Ali Doroudchi et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan—A Critical Review

(2019) Hongjie Yuan et al.   MOLECULES

Th9 cells in allergic diseases: A role for the microbiota?

(2019) Isabella Badolati et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

(2019) David Michalovich et al.   Nature Communications

The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma

(2019) Giancarlo Marone et al.   Frontiers in Pharmacology

Interleukin-5 in the Pathophysiology of Severe Asthma

(2019) Corrado Pelaia et al.   Frontiers in Physiology

T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma

(2019) Fang Gong et al.   Frontiers in Immunology

Intranasal administration of probiotic Lactobacillus rhamnosus GG prevents birch pollen-induced allergic asthma in a murine model

(2018) Irina Spacova et al.   ALLERGY

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

(2018) Hannah M. Knochelmann et al.   Cellular & Molecular Immunology

Maternal antibiotic use and child asthma: is the association causal?

(2018) Mingyu Zhang et al.   EUROPEAN RESPIRATORY JOURNAL

Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy

(2018) Yin Yao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation

(2018) Xiang Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Asthma

(2018) Alberto Papi et al.   LANCET

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic Control of Interleukin-9 in Asthma

(2018) Clare M. Lloyd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma

(2018) Alexander J. Adami et al.   PEDIATRIC RESEARCH

miR-192 suppresses T follicular helper cell differentiation by targeting CXCR5 in childhood asthma

(2018) Defeng Zhang et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

(2018) Ilkka S. Junttila   Frontiers in Immunology

Effects of Anti-IL-17 on Inflammation, Remodeling, and Oxidative Stress in an Experimental Model of Asthma Exacerbated by LPS

(2018) Leandro do Nascimento Camargo et al.   Frontiers in Immunology

The Role of Skin and Orogenital Microbiota in Protective Immunity and Chronic Immune-Mediated Inflammatory Disease

(2018) Young Joon Park et al.   Frontiers in Immunology

Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

(2018) Faith. I. Uwadiae et al.   ALLERGY

BETting on Novel Treatments for Asthma: Bromodomain 4 Inhibitors

(2018) Yan Y Sanders et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease

(2018) Merin E. Kuruvilla et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Bifidobacterium breve MRx0004 protects against airway inflammation in a severe asthma model by suppressing both neutrophil and eosinophil lung infiltration

(2018) Emma J. Raftis et al.   Scientific Reports

Does Breast Milk Nurture T Lymphocytes in Their Cradle?

(2018) Peter S. Hsu et al.   Frontiers in Pediatrics

The Role of the Microbiome in Asthma: The Gut–Lung Axis

(2018) Franco Frati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The gut microbiome: Relationships with disease and opportunities for therapy

(2018) Juliana Durack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice

(2018) Line Fisker Zachariassen et al.   JOURNAL OF IMMUNOLOGY

Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment

(2017) Juliana Durack et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Staphylococcal serine protease–like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus

(2017) Sebastian Stentzel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Follicular helper T cells mediate IgE antibody response to airborne allergens

(2017) Takao Kobayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathogenic CD4 + T cells in patients with asthma

(2017) Lyndsey M. Muehling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

(2017) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice

(2017) Akihito Nakajima et al.   JOURNAL OF IMMUNOLOGY

Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma

(2017) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-17A directly acts on bronchial smooth muscle cells and augments the contractility

(2017) Yoshihiko Chiba et al.   Pharmacological Reports

Prophylactic Supplementation of Bifidobacterium longum 51A Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsiveness

(2017) Eduardo Mendes et al.   Frontiers in Microbiology

The Influence of the Microbiome on Early-Life Severe Viral Lower Respiratory Infections and Asthma—Food for Thought?

(2017) Jason P. Lynch et al.   Frontiers in Immunology

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice

(2016) A. Noble et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma

(2016) L. T. Stiemsma et al.   CLINICAL SCIENCE

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite

(2016) André Ballesteros-Tato et al.   IMMUNITY

IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis

(2016) Laura K. Johnston et al.   JOURNAL OF IMMUNOLOGY

Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma

(2016) Grégory Seumois et al.   JOURNAL OF IMMUNOLOGY

Th9 cells in immunity and immunopathological diseases

(2016) Markus F. Neurath et al.   Seminars in Immunopathology

Th9 and other IL-9-producing cells in allergic asthma

(2016) Sonja Koch et al.   Seminars in Immunopathology

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Kimchi and Other Widely Consumed Traditional Fermented Foods of Korea: A Review

(2016) Jayanta Kumar Patra et al.   Frontiers in Microbiology

Novel approaches to the management of noneosinophilic asthma

(2016) Neil C. Thomson   Therapeutic Advances in Respiratory Disease

IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma

(2015) Cynthia R. Willis et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

Mast cell production and response to IL-4 and IL-13

(2015) Jamie J.A. McLeod et al.   CYTOKINE

Airway dysbiosis:Haemophilus influenzaeandTropherymain poorly controlled asthma

(2015) Jodie L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Interleukin-21-Producing CD4+ T Cells Promote Type 2 Immunity to House Dust Mites

(2015) Jonathan M. Coquet et al.   IMMUNITY

TH9 cells are required for tissue mast cell accumulation during allergic inflammation

(2015) Sarita Sehra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults

(2015) Meghan F. Davis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The airway microbiome in patients with severe asthma: Associations with disease features and severity

(2015) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

(2015) Emma S. Chambers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

(2015) Norbert Krug et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early infancy microbial and metabolic alterations affect risk of childhood asthma

(2015) Marie-Claire Arrieta et al.   Science Translational Medicine

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

(2015) Mario Castro et al.   Lancet Respiratory Medicine

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

(2014) J. Pene et al.   JOURNAL OF IMMUNOLOGY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

(2014) Benjamin J. Green et al.   PLoS One

Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis

(2014) A. K. Ortqvist et al.   BMJ-British Medical Journal

Breastfeeding as a Modifier of the Respiratory Effects of Air Pollution in Children

(2013) Guang-Hui Dong et al.   EPIDEMIOLOGY

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

(2013) Alexandra M. Nanzer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Concurrent treatment of chronic psoriasis and asthma with ustekinumab

(2013) Ajay Amarnani et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Role of the gut microbiota in human nutrition and metabolism

(2013) Balakrishnan S Ramakrishna   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Eosinophils in the Spotlight: Eosinophilic airway inflammation in nonallergic asthma

(2013) Guy G Brusselle et al.   NATURE MEDICINE

A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma

(2013) Chad K Oh et al.   RESPIRATORY RESEARCH

IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation

(2013) Dawn Catherine Newcomb et al.   THORAX

Effects of Interleukin-9 Blockade on Chronic Airway Inflammation in Murine Asthma Models

(2013) Myung Shin Kim et al.   Allergy Asthma & Immunology Research

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Th17-associated cytokines promote human airway smooth muscle cell proliferation

(2012) Ying Chang et al.   FASEB JOURNAL

Activin A and TGF-β promote TH9 cell–mediated pulmonary allergic pathology

(2012) Carla P. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

Bacteria in sputum of stable severe asthma and increased airway wall thickness

(2012) Qingling Zhang et al.   RESPIRATORY RESEARCH

Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy

(2011) Frederika A. van Nimwegen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TH17 cytokines induce human airway smooth muscle cell migration

(2011) Ying Chang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin (IL)-4, IL-13 and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients

(2011) A Bellini et al.   Mucosal Immunology

Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development

(2010) E Mosconi et al.   Mucosal Immunology

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

Randomized placebo-controlled trial of lactobacillus on asthmatic children with allergic rhinitis

(2010) Yue-Sheng Chen et al.   PEDIATRIC PULMONOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

The NIH Human Microbiome Project

(2009) et al.   GENOME RESEARCH

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE