The mechanisms and roles of mitochondrial dynamics in C. elegans

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics

(2023) Juliane Cruz Campos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased mitochondrial Ca2+ contributes to health decline with age and Duchene muscular dystrophy in C. elegans

(2023) Atsushi Higashitani et al.   FASEB JOURNAL

ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

(2023) Chuan-Yang Dai et al.   NATURE CELL BIOLOGY

Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness

(2022) Lana Meshnik et al.   BMC BIOLOGY

Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer’s disease relevant tau modification in a novel Caenorhabditis elegans model

(2022) Sanjib Guha et al.   GENETICS

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

(2022) Jonas Benjamin Michaelis et al.   Nature Communications

UniProt: the Universal Protein Knowledgebase in 2023

(2022) et al.   NUCLEIC ACIDS RESEARCH

An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion

(2022) Tricia T Nguyen et al.   eLife

Actin cables and comet tails organize mitochondrial networks in mitosis

(2021) Andrew S. Moore et al.   NATURE

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies

(2021) Hazel J. Shields et al.   Frontiers in Cell and Developmental Biology

Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans

(2021) Li-Tzu Chen et al.   DEVELOPMENTAL CELL

Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1–dependent process

(2021) Yanfang Chen et al.   JOURNAL OF CELL BIOLOGY

Distinct fission signatures predict mitochondrial degradation or biogenesis

(2021) Tatjana Kleele et al.   NATURE

Genome-wide RNAi screen for regulators of UPRmt in Caenorhabditis elegans mutants with defects in mitochondrial fusion

(2021) Simon Haeussler et al.   G3-Genes Genomes Genetics

Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy

(2021) Konstantinos Palikaras et al.   Aging-US

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation

(2021) Annika Traa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zearalenone Induces Dopaminergic Neurodegeneration via DRP-1-Involved Mitochondrial Fragmentation and Apoptosis in a Caenorhabditis elegans Parkinson’s Disease Model

(2021) Chia-Cheng Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

(2020) Robert G. Abrisch et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

(2020) Yasmine J. Liu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial Functions in Infection and Immunity

(2020) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death

(2020) Song Han et al.   Cells

Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways

(2020) Emily Machiela et al.   FASEB JOURNAL

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

(2020) Yasmine J. Liu et al.   JOURNAL OF CELL BIOLOGY

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

(2020) Ayeshah A. Rosdah et al.   PHARMACOLOGY & THERAPEUTICS

Pseudomonas aeruginosa N-3-Oxo-Dodecanoyl-Homoserine Lactone Impacts Mitochondrial Networks Morphology, Energetics, and Proteome in Host Cells

(2020) Henrik Josephson et al.   Frontiers in Microbiology

Better to keep in touch: investigating inter‐organelle cross‐talk

(2020) Michela Rossini et al.   FEBS Journal

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism

(2020) Wei Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans

(2020) Andrea Princz et al.   Scientific Reports

Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy

(2020) Hongxu Xian et al.   CELL DEATH AND DIFFERENTIATION

Paraquat exposure over generation affects lifespan and reproduction through mitochondrial disruption in C. elegans

(2020) Snigdha Bora et al.   TOXICOLOGY

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

(2019) Davide D’Amico et al.   MOLECULAR CELL

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline

(2019) Toby Lieber et al.   NATURE

Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans

(2019) Nikolaos Charmpilas et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Network State Scales mtDNA Genetic Dynamics

(2019) Juvid Aryaman et al.   GENETICS

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

(2019) Jessica H. Hartman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

(2019) Hongxu Xian et al.   Nature Communications

Mitochondrial fusion is required for regulation of mitochondrial DNA replication

(2019) Eduardo Silva Ramos et al.   PLoS Genetics

Mitochondrial Oxidative Stress Impairs Energy Metabolism and Reduces Stress Resistance and Longevity of C. elegans

(2019) Benjamin Dilberger et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Genome (mtDNA) Mutations that Generate Reactive Oxygen Species

(2019) Hahn et al.   Antioxidants

Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson’s models

(2018) Hanna Kim et al.   Cell Death & Disease

DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants

(2018) Charlotte Scholtes et al.   Scientific Reports

The Cellular Mitochondrial Genome Landscape in Disease

(2018) Anne Hahn et al.   TRENDS IN CELL BIOLOGY

A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage

(2017) K. Adam Bohnert et al.   NATURE

Microbial metabolites regulate host lipid metabolism through NR5A–Hedgehog signalling

(2017) Chih-Chun Janet Lin et al.   NATURE CELL BIOLOGY

Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability

(2017) Anthony L. Luz et al.   TOXICOLOGY

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

(2017) Snehal N. Chaudhari et al.   Nature Communications

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons

(2016) N. S. Morsci et al.   JOURNAL OF NEUROSCIENCE

Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis

(2016) Yongping Zhang et al.   MOLECULAR CELL

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan

(2016) Saroj G. Regmi et al.   Aging-US

The BCL-2–like protein CED-9 ofC. eleganspromotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion

(2016) Stéphane G. Rolland et al.   JOURNAL OF CELL BIOLOGY

IBS: an illustrator for the presentation and visualization of biological sequences: Fig. 1.

(2015) Wenzhong Liu et al.   BIOINFORMATICS

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Neural activity and CaMKII protect mitochondria from fragmentation in agingCaenorhabditis elegansneurons

(2015) Hao-Ching Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells

(2015) Junghyung Park et al.   TOXICOLOGY

Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

(2015) Jean-Philippe Leduc-Gaudet et al.   Oncotarget

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

(2013) Qinfang Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2

(2013) Piya Ghose et al.   PLoS Genetics

Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans

(2012) Amanda S. Bess et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans

(2011) Qinghua Zhou et al.   CELL RESEARCH

Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways

(2011) Thomas Rival et al.   EMBO REPORTS

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans

(2011) Brian P. Head et al.   MOLECULAR BIOLOGY OF THE CELL

A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans

(2011) Y. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Listeria monocytogenestransiently alters mitochondrial dynamics during infection

(2011) Fabrizia Stavru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology

(2010) Ji Young Mun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex

(2010) A. Misko et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Fragmentation Leads to Intracellular Acidification in Caenorhabditis elegans and Mammalian Cells

(2010) David Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA

(2009) Adriana Malena et al.   HUMAN MOLECULAR GENETICS

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans

(2009) Stephen Dingley et al.   MITOCHONDRION

Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development

(2009) Ivana Bratic et al.   NUCLEIC ACIDS RESEARCH

Heterozygous Mutation of Opa1 in Drosophila Shortens Lifespan Mediated through Increased Reactive Oxygen Species Production

(2009) Sha Tang et al.   PLoS One

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

(2009) K. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential

(2008) Olwenn Guillery et al.   BIOLOGY OF THE CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Effects of overexpression of Huntingtin proteins on mitochondrial integrity

(2008) Hongmin Wang et al.   HUMAN MOLECULAR GENETICS

An RNAi Screen for Mitochondrial Proteins Required to Maintain the Morphology of the Organelle in Caenorhabditis elegans

(2008) Ryohei Ichishita et al.   JOURNAL OF BIOCHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent of ced-9

(2008) David G. Breckenridge et al.   MOLECULAR CELL

NCBI BLAST: a better web interface

(2008) M. Johnson et al.   NUCLEIC ACIDS RESEARCH

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals

(2008) Takayuki Kanazawa et al.   PLoS Genetics