ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria

(2022) Qiyuan Yang et al.   NATURE CELL BIOLOGY

Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan

(2021) Tara R. Richman et al.   AGING CELL

Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

(2021) Tanima SenGupta et al.   Cell Reports

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

(2020) Marte Molenaars et al.   Cell Metabolism

A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR

(2020) Siraje Arif Mahmud et al.   PLoS Pathogens

Mitochondrial UPR repression duringPseudomonas aeruginosainfection requires the bZIP protein ZIP-3

(2019) Pan Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation

(2019) Nicola Ferreira et al.   EMBO JOURNAL

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

(2018) Arnaud Ahier et al.   NATURE CELL BIOLOGY

Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans

(2018) Suraiya Haroon et al.   Cell Reports

Simplified qPCR method for detecting excessive mtDNA damage induced by exogenous factors

(2017) Artem P. Gureev et al.   TOXICOLOGY

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

(2016) Bryan L. Gitschlag et al.   Cell Metabolism

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons

(2016) Annika L.A. Nichols et al.   Cell Reports

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon

(2014) Christian Frøkjær-Jensen et al.   NATURE METHODS

A novel intermediate in transcription initiation by human mitochondrial RNA polymerase

(2014) Yaroslav I. Morozov et al.   NUCLEIC ACIDS RESEARCH

Sequential histone-modifying activities determine the robustness of transdifferentiation

(2014) S. Zuryn et al.   SCIENCE

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus

(2013) Jesús F. Torres-Peraza et al.   BRAIN

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Mitochondrial DNA damage and its consequences for mitochondrial gene expression

(2012) Susan D. Cline   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents

(2010) Hanne K. Skjeldam et al.   DNA REPAIR

The mitochondrial transcription factor A functions in mitochondrial base excision repair

(2010) Chandrika Canugovi et al.   DNA REPAIR

The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number

(2010) Senyene E. Hunter et al.   METHODS

Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development

(2009) Ivana Bratic et al.   NUCLEIC ACIDS RESEARCH

Limited clinical relevance of mitochondrial DNA mutation and gene expression analyses in ovarian cancer

(2008) Piotr Bragoszewski et al.   BMC CANCER

Quantification of mitochondrial DNA (mtDNA) damage and error rates by real-time QPCR

(2008) John G. Edwards   MITOCHONDRION

Genetic analysis of crawling and swimming locomotory patterns in C. elegans

(2008) J. T. Pierce-Shimomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA