Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

Mitochondria shed their outer membrane in response to infection-induced stress

(2022) Xianhe Li et al.   SCIENCE

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding

(2021) Chun-Shik Shin et al.   Nature Communications

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery

(2021) Jasmin Adriana Schäfer et al.   MOLECULAR CELL

Mitophagy of polarized sperm-derived mitochondria after fertilization

(2020) Karinna Rubio-Peña et al.   iScience

Disease-Associated Genetic Variation in Human Mitochondrial Protein Import

(2019) Emmanuelle Nicolas et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

(2019) Peng Wang et al.   PLoS Genetics

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

(2019) Chaojun Yan et al.   Autophagy

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

(2019) Atsushi Hoshino et al.   NATURE

Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans

(2019) Leila Lesanpezeshki et al.   Scientific Reports

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

(2019) Kevin Klann et al.   MOLECULAR CELL

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells

(2018) Nina Meyer et al.   Autophagy

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology

(2018) Fenglei Jian et al.   Cell Reports

Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease

(2018) Sandra Franco-Iborra et al.   Frontiers in Neuroscience

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response

(2018) Olga Zurita Rendón et al.   MOLECULAR AND CELLULAR BIOLOGY

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer

(2018) Florian Meier et al.   MOLECULAR & CELLULAR PROTEOMICS

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease

(2017) Anne-Laure Bulteau et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23

(2017) See-Yeun Ting et al.   eLife

Approaches for Studying Autophagy in Caenorhabditis elegans

(2017) Yanfang Chen et al.   Cells

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Molecular architecture of the active mitochondrial protein gate

(2015) T. Shiota et al.   SCIENCE

Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia

(2015) Beryl Royer-Bertrand et al.   Scientific Reports

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice

(2014) Fotis Ioakeimidis et al.   PLoS One

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

(2014) L F Burbulla et al.   Cell Death & Disease

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases

(2013) Martina Wirth et al.   MITOCHONDRION

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

(2012) S. H. Bernstein et al.   BLOOD

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Processing of mitochondrial presequences

(2011) Dirk Mossmann et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Tim50’s presequence receptor domain is essential for signal driven transport across the TIM23 complex

(2011) Christian Schulz et al.   JOURNAL OF CELL BIOLOGY

Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer

(2010) B. H. Kang et al.   CLINICAL CANCER RESEARCH

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Reverse pH-Dependence of Chromophore Protonation Explains the Large Stokes Shift of the Red Fluorescent Protein mKeima

(2009) Sebastien Violot et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

(2009) Dejana Mokranjac et al.   MOLECULAR BIOLOGY OF THE CELL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY