Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

(2020) Friederike Roger et al.   eLife

Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field

(2019) Meghri Katerji et al.   Oxidative Medicine and Cellular Longevity

The Naked Mole Rat: A Unique Example of Positive Oxidative Stress

(2019) Frédéric Saldmann et al.   Oxidative Medicine and Cellular Longevity

The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses

(2019) Daniel Munro et al.   AGING CELL

N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression

(2019) Prakshit Niraula et al.   BIOGERONTOLOGY

Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging

(2019) José Raúl Pérez-Estrada et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity

(2018) Laura Anaissi-Afonso et al.   ACS Chemical Biology

Biosensors for spatiotemporal detection of reactive oxygen species in cells and tissues

(2018) Marie Erard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans

(2018) Fang Li et al.   EXPERIMENTAL GERONTOLOGY

Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging

(2018) Tina Oberacker et al.   FEBS LETTERS

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

The Comparative Biology of Mitochondrial Function and the Rate of Aging

(2018) Steven N Austad   INTEGRATIVE AND COMPARATIVE BIOLOGY

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Glutaredoxin Deletion Shortens Chronological Life Span in Saccharomyces cerevisiae via ROS-Mediated Ras/PKA Activation

(2018) Yan Liu et al.   JOURNAL OF PROTEOME RESEARCH

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms

(2018) Ana L. Santos et al.   Oxidative Medicine and Cellular Longevity

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

(2018) Megan M. Senchuk et al.   PLoS Genetics

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Resolving the Enigma of the Clonal Expansion of mtDNA Deletions

(2018) Axel Kowald et al.   Genes

Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling

(2018) Carly S. Cox et al.   Cell Metabolism

Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice

(2018) Geneva M. Cunningham et al.   GeroScience

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

(2018) Ziyun Wu et al.   BMC BIOLOGY

Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes

(2018) Cecilia Picazo et al.   Scientific Reports

The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells

(2018) Noemi Di Marzo et al.   Cells

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans

(2017) Dylan J. Dues et al.   FREE RADICAL BIOLOGY AND MEDICINE

What modulates animal longevity? Fast and slow aging in bivalves as a model for the study of lifespan

(2017) Pierre U. Blier et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Slow aging in mammals—Lessons from African mole-rats and bats

(2017) Philip Dammann   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

(2017) Collin Yvès Ewald et al.   eLife

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

(2017) Giang T. Nguyen et al.   Frontiers in Cellular and Infection Microbiology

Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

(2017) Nadine Urban et al.   Redox Biology

Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling

(2017) Rui D.M. Travasso et al.   Redox Biology

Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging inCaenorhabditis elegans

(2016) David Desjardins et al.   AGING CELL

The role of peroxiredoxin 4 in inflammatory response and aging

(2016) Vladimir I. Klichko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins

(2016) Sarah Hanzén et al.   CELL

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

(2016) Kathy K. Griendling et al.   CIRCULATION RESEARCH

Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme

(2016) Maria Giulia Battelli et al.   CURRENT MEDICINAL CHEMISTRY

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Overview on Peroxiredoxin

(2016)   MOLECULES AND CELLS

Roles for ROS and hydrogen sulfide in the longevity response to germline loss inCaenorhabditis elegans

(2016) Yuehua Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lifespan extension and increased resistance to environmental stressors by N-Acetyl-L-Cysteine in Caenorhabditis elegans

(2015) SI Oh et al.   Clinics

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

Phospholipid fatty acid composition linking larval-density to lifespan of adult Drosophila melanogaster

(2015) Neda Nasiri Moghadam et al.   EXPERIMENTAL GERONTOLOGY

Longevity Is Linked to Mitochondrial Mutation Rates in Rockfish: A Test Using Poisson Regression

(2015) Xia Hua et al.   MOLECULAR BIOLOGY AND EVOLUTION

The cell biology of aging

(2015) Race DiLoreto et al.   MOLECULAR BIOLOGY OF THE CELL

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

(2015) Arden Perkins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

(2015) Claire E. Schaar et al.   PLoS Genetics

Simplified 2,4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins

(2014) Cristina S. Mesquita et al.   ANALYTICAL BIOCHEMISTRY

Measurement of DCF fluorescence as a measure of reactive oxygen species in murine islets of Langerhans

(2014) Xue Wang et al.   Analytical Methods

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging inCaenorhabditis elegans

(2014) Taro Sakamoto et al.   GENES TO CELLS

An overview of mechanisms of redox signaling

(2014) Henry Jay Forman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Multimarker Screening of Oxidative Stress in Aging

(2014) Kamila Syslová et al.   Oxidative Medicine and Cellular Longevity

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase

(2014) I. Pader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

Effect of Antioxidants Supplementation on Aging and Longevity

(2014) Izabela Sadowska-Bartosz et al.   Biomed Research International

The “Goldilocks Zone” from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle

(2014) Rick J. Alleman et al.   Frontiers in Physiology

Reactive oxygen species and redox compartmentalization

(2014) Nina Kaludercic et al.   Frontiers in Physiology

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

(2013) Sebastian Schmeisser et al.   AGING CELL

Novel interactions between mitochondrial superoxide dismutases and the electron transport chain

(2013) Wichit Suthammarak et al.   AGING CELL

Mitochondrial energetics is impairedin vivoin aged skeletal muscle

(2013) Gilles Gouspillou et al.   AGING CELL

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

(2013) Gustavo Barja   ANTIOXIDANTS & REDOX SIGNALING

Involvement of Redox State in the Aging of Drosophila melanogaster

(2013) William C. Orr et al.   ANTIOXIDANTS & REDOX SIGNALING

Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

(2013) C. Selman et al.   Biology Letters

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Antioxidant Supplements to Prevent Mortality

(2013) Goran Bjelakovic et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oxidative stress and mitochondrial protein quality control in aging

(2013) Eirini Lionaki et al.   Journal of Proteomics

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Vitamin E supplementation and lifespan in model organisms

(2012) I.M.A. Ernst et al.   AGEING RESEARCH REVIEWS

The role of DNA damage and repair in aging through the prism of Koch-like criteria

(2012) Alexey A. Moskalev et al.   AGEING RESEARCH REVIEWS

The Characterization of the Caenorhabditis elegans Mitochondrial Thioredoxin System Uncovers an Unexpected Protective Role of Thioredoxin Reductase 2 in β-Amyloid Peptide Toxicity

(2012) Briseida Cacho-Valadez et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

(2012) Samuel Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease

(2012) Pei-Chi Wei et al.   MOLECULAR CELL

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans

(2012) Weixun Li et al.   MOLECULES AND CELLS

Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress

(2012) Vamsi Rani et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Neuroprotective Effects of N-Acetyl-Cysteine and Acetyl-L-Carnitine after Spinal Cord Injury in Adult Rats

(2012) Amar Karalija et al.   PLoS One

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

8-Hydroxydeoxyguanosine: Not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases

(2012) Chan-Young Ock   WORLD JOURNAL OF GASTROENTEROLOGY

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

(2011) Ying Xiong et al.   ANTIOXIDANTS & REDOX SIGNALING

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

CARBONYL FORMATION IN ERYTHROCYTE MEMBRANE PROTEINS DURING AGING IN HUMANS

(2011) Rashmi Jha et al.   BIOMEDICAL PAPERS-OLOMOUC

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

(2011) Filipe Cabreiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA mutations in disease and aging

(2011) Chan Bae Park et al.   JOURNAL OF CELL BIOLOGY

The Effects of Vitamin Supplementation on Drosophila Life Span Under Normoxia and Under Oxidative Stress

(2011) S. Bahadorani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice

(2011) V. I. Perez et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Extreme Longevity Is Associated With Increased Resistance to Oxidative Stress in Arctica islandica, the Longest-Living Non-Colonial Animal

(2011) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Life Span Extension and H2O2 Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae

(2011) Mikael Molin et al.   MOLECULAR CELL

Extension of Lifespan in C. elegans by Naphthoquinones That Act through Stress Hormesis Mechanisms

(2011) Piper R. Hunt et al.   PLoS One

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Antioxidant enzyme activities are not broadly correlated with longevity in 14 vertebrate endotherm species

(2010) Melissa M. Page et al.   AGE

Identification of evolutionarily conserved genetic regulators of cellular aging

(2010) Gerhard T. Laschober et al.   AGING CELL

Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?

(2010) Jeremy Michael Van Raamsdonk et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress during aging of the yeast in a stationary culture and its attenuation by antioxidants

(2010) Alina Owsiak et al.   CELL BIOLOGY INTERNATIONAL

The lipophilic antioxidants α-tocopherol and coenzyme Q10 reduce the replicative lifespan of Saccharomyces cerevisiae

(2010) Yuen Ting Lam et al.   FREE RADICAL BIOLOGY AND MEDICINE

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

(2010) Gabriel Loor et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage

(2010) J. M. Van Raamsdonk et al.   GENETICS

Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice

(2010) K. Flurkey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

(2009) Gillian Groeger et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Carbonyl and the Methionine Sulfoxide Reductase System

(2009) Jackob Moskovitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity inDrosophila

(2009) Svetlana N. Radyuk et al.   BIOCHEMICAL JOURNAL

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1

(2009) Tanja Heidler et al.   BIOGERONTOLOGY

When a theory of aging ages badly

(2009) Jérôme Lapointe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis

(2009) Adam B. Salmon et al.   FASEB JOURNAL

JNK/FOXO-mediated Neuronal Expression of Fly Homologue of Peroxiredoxin II Reduces Oxidative Stress and Extends Life Span

(2009) Kyu-Sun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

(2009) Y. Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice

(2009) S. P. Singh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan

(2009) Ayumi Shibamura et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A bad boy comes good

(2009) Ulrich Theopold   NATURE

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms

(2008) Rochelle Buffenstein et al.   AGE

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species

(2008) Romana Fato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Function of reactive oxygen species during animal development: Passive or active?

(2008) Luis Covarrubias et al.   DEVELOPMENTAL BIOLOGY

The wanderings of a free radical

(2008) Barry Halliwell   FREE RADICAL BIOLOGY AND MEDICINE

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity

(2008) J. R. Managbanag et al.   PLoS One

A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance

(2008) M. Olahova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

(2007) Viviana I. Pérez et al.   FREE RADICAL BIOLOGY AND MEDICINE