Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development

Hedgehog signaling mechanism and role in cancer

(2021) Jin Jiang   SEMINARS IN CANCER BIOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Mechanisms of Smoothened Regulation in Hedgehog Signaling

(2021) Jie Zhang et al.   Cells

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling

(2020) Xiaofeng Qi et al.   TRENDS IN BIOCHEMICAL SCIENCES

mCSM-membrane: predicting the effects of mutations on transmembrane proteins

(2020) Douglas E V Pires et al.   NUCLEIC ACIDS RESEARCH

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway

(2020) Sarah Findakly et al.   JOURNAL OF CELL BIOLOGY

Biochemical mechanisms of vertebrate hedgehog signaling

(2019) Jennifer H. Kong et al.   DEVELOPMENT

Phosphatidic acid in membrane rearrangements

(2019) Mikhail A. Zhukovsky et al.   FEBS LETTERS

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

(2019) Xiaofeng Qi et al.   NATURE

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

(2019) Ishan Deshpande et al.   NATURE

PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila

(2019) Jialin Fan et al.   Cell Discovery

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

(2019) Maia Kinnebrew et al.   eLife

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

(2018) Eamon FX Byrne et al.   CURRENT OPINION IN CELL BIOLOGY

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases

(2018) Shuang Li et al.   Science Signaling

Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases

(2018) Shuang Li et al.   Science Signaling

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

(2018) Xiaofeng Qi et al.   NATURE

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex

(2018) Xiaofeng Qi et al.   SCIENCE

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

Cilia-Associated Oxysterols Activate Smoothened

(2018) David R. Raleigh et al.   MOLECULAR CELL

Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis

(2017) Nawal Kassas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

(2017) Xu Xiao et al.   MOLECULAR CELL

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium

(2017) Benjamin R. Myers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties

(2016) Priya Putta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Hedgehog Pathway Inhibition

(2016) Aleksandar Sekulic et al.   CELL

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division

(2016) Yoshihiro Adachi et al.   MOLECULAR CELL

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

(2016) Kai Jiang et al.   PLOS BIOLOGY

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

Control of the dynamics and homeostasis of theDrosophilaHedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

(2015) Amira Brigui et al.   Open Biology

Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation

(2014) S. Li et al.   Science Signaling

Decoding the phosphorylation code in Hedgehog signal transduction

(2013) Yongbin Chen et al.   CELL RESEARCH

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells

(2013) F. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

(2013) Rajashree Rana et al.   Nature Communications

Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

(2013) Shoujun Huang et al.   PLOS BIOLOGY

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

(2013) Sigrid Nachtergaele et al.   eLife

Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner

(2012) Junkai Fan et al.   DEVELOPMENTAL BIOLOGY

Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential

(2012) Malini Guha   NATURE REVIEWS DRUG DISCOVERY

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

(2011) Michel Bidet et al.   PLoS One

Focus Issue: Fine-Tuning Hedgehog Signaling in Development and Disease

(2011) A. M. VanHook   Science Signaling

Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling

(2010) Amir Yavari et al.   DEVELOPMENTAL CELL

Genetic and biochemical definition of the Hedgehog receptor

(2010) X. Zheng et al.   GENES & DEVELOPMENT

Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus

(2010) Hongge Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

(2008) H. Jia et al.   DEVELOPMENT

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL