Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation

(2013) Zhao Zhang et al.   DEVELOPMENTAL CELL

The Niche-Dependent Feedback Loop Generates a BMP Activity Gradient to Determine the Germline Stem Cell Fate

(2012) Laixin Xia et al.   CURRENT BIOLOGY

A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20

(2012) Michael Blank et al.   NATURE MEDICINE

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

(2012) J. Fombonne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Effective gene silencing in Drosophila ovarian germline by artificial microRNAs

(2011) Hailong Wang et al.   CELL RESEARCH

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response

(2010) Laixin Xia et al.   CELL

Genetic and biochemical definition of the Hedgehog receptor

(2010) X. Zheng et al.   GENES & DEVELOPMENT

Ihog and Boi are essential for Hedgehog signaling in Drosophila

(2010) Darius Camp et al.   Neural Development

Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient

(2010) A. Casali   Science Signaling

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

Temporal dynamics of patterning by morphogen gradients

(2009) Eva Kutejova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila

(2009) D. Chen et al.   DEVELOPMENT

The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates

(2009) Abiodun A. Ogunjimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc

(2009) Marcos Nahmad et al.   PLOS BIOLOGY

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Otefin, a Nuclear Membrane Protein, Determines the Fate of Germline Stem Cells in Drosophila via Interaction with Smad Complexes

(2008) Xiaoyong Jiang et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Two Patched Protein Subtypes and a Conserved Domain of Group I Proteins That Regulates Turnover

(2008) Shiho Kawamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY