Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development
出版年份 2023 全文链接
标题
Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in
Drosophila
wing development
作者
关键词
-
出版物
Science Signaling
Volume 16, Issue 807, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2023-10-18
DOI
10.1126/scisignal.add6834
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hedgehog signaling mechanism and role in cancer
- (2021) Jin Jiang SEMINARS IN CANCER BIOLOGY
- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- Mechanisms of Smoothened Regulation in Hedgehog Signaling
- (2021) Jie Zhang et al. Cells
- AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
- (2021) Mihaly Varadi et al. NUCLEIC ACIDS RESEARCH
- Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling
- (2020) Xiaofeng Qi et al. TRENDS IN BIOCHEMICAL SCIENCES
- mCSM-membrane: predicting the effects of mutations on transmembrane proteins
- (2020) Douglas E V Pires et al. NUCLEIC ACIDS RESEARCH
- Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway
- (2020) Sarah Findakly et al. JOURNAL OF CELL BIOLOGY
- Biochemical mechanisms of vertebrate hedgehog signaling
- (2019) Jennifer H. Kong et al. DEVELOPMENT
- Phosphatidic acid in membrane rearrangements
- (2019) Mikhail A. Zhukovsky et al. FEBS LETTERS
- Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
- (2019) Xiaofeng Qi et al. NATURE
- Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
- (2019) Ishan Deshpande et al. NATURE
- PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila
- (2019) Jialin Fan et al. Cell Discovery
- Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
- (2019) Maia Kinnebrew et al. eLife
- Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
- (2018) Eamon FX Byrne et al. CURRENT OPINION IN CELL BIOLOGY
- Structural basis for the recognition of Sonic Hedgehog by human Patched1
- (2018) Xin Gong et al. SCIENCE
- Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases
- (2018) Shuang Li et al. Science Signaling
- Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases
- (2018) Shuang Li et al. Science Signaling
- Structures of human Patched and its complex with native palmitoylated sonic hedgehog
- (2018) Xiaofeng Qi et al. NATURE
- Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex
- (2018) Xiaofeng Qi et al. SCIENCE
- Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched
- (2018) Yunxiao Zhang et al. CELL
- Cilia-Associated Oxysterols Activate Smoothened
- (2018) David R. Raleigh et al. MOLECULAR CELL
- Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis
- (2017) Nawal Kassas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling
- (2017) Xu Xiao et al. MOLECULAR CELL
- Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
- (2017) Benjamin R. Myers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
- (2016) Priya Putta et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling
- (2016) Pengxiang Huang et al. CELL
- Hedgehog Pathway Inhibition
- (2016) Aleksandar Sekulic et al. CELL
- Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy
- (2016) Ekaterina Pak et al. DEVELOPMENTAL CELL
- Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division
- (2016) Yoshihiro Adachi et al. MOLECULAR CELL
- Structural basis of Smoothened regulation by its extracellular domains
- (2016) Eamon F. X. Byrne et al. NATURE
- PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail
- (2016) Kai Jiang et al. PLOS BIOLOGY
- Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
- (2016) Giovanni Luchetti et al. eLife
- Control of the dynamics and homeostasis of theDrosophilaHedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases
- (2015) Amira Brigui et al. Open Biology
- Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation
- (2014) S. Li et al. Science Signaling
- Decoding the phosphorylation code in Hedgehog signal transduction
- (2013) Yongbin Chen et al. CELL RESEARCH
- Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response
- (2013) Benjamin R. Myers et al. DEVELOPMENTAL CELL
- Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells
- (2013) F. Zhang et al. MOLECULAR AND CELLULAR BIOLOGY
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
- (2013) Rajashree Rana et al. Nature Communications
- Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover
- (2013) Shoujun Huang et al. PLOS BIOLOGY
- Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
- (2013) Sigrid Nachtergaele et al. eLife
- Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner
- (2012) Junkai Fan et al. DEVELOPMENTAL BIOLOGY
- Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential
- (2012) Malini Guha NATURE REVIEWS DRUG DISCOVERY
- USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization
- (2012) Ruohan Xia et al. PLOS BIOLOGY
- Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila
- (2012) Shuang Li et al. PLOS BIOLOGY
- The Hedgehog Receptor Patched Is Involved in Cholesterol Transport
- (2011) Michel Bidet et al. PLoS One
- Focus Issue: Fine-Tuning Hedgehog Signaling in Development and Disease
- (2011) A. M. VanHook Science Signaling
- Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling
- (2010) Amir Yavari et al. DEVELOPMENTAL CELL
- Genetic and biochemical definition of the Hedgehog receptor
- (2010) X. Zheng et al. GENES & DEVELOPMENT
- Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus
- (2010) Hongge Jia et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
- (2008) H. Jia et al. DEVELOPMENT
- Hedgehog Signaling in Development and Cancer
- (2008) Jin Jiang et al. DEVELOPMENTAL CELL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More