Inflammaging decreases adaptive and innate immune responses in mice and humans

Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine

(2015) Daniela Frasca et al.   VACCINE

You Are What You Host: Microbiome Modulation of the Aging Process

(2014) Caroline Heintz et al.   CELL

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mouse CMV infection delays antibody class switch upon an unrelated virus challenge

(2014) Thomas F. Marandu et al.   EXPERIMENTAL GERONTOLOGY

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs

(2014) Cecilia A. Hinojosa et al.   EXPERIMENTAL GERONTOLOGY

High TNF-α levels in resting B cells negatively correlate with their response

(2014) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

Latent Infection with Cytomegalovirus Is Associated with Poor Memory CD4 Responses to Influenza A Core Proteins in the Elderly

(2014) Evelyna Derhovanessian et al.   JOURNAL OF IMMUNOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

(2014) Hye-Lim Park et al.   Human Vaccines & Immunotherapeutics

The Immune Protective Effect of the Mediterranean Diet against Chronic Low-grade Inflammatory Diseases

(2014) Rosa Casas et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

A new role for microRNAs, as ligands of Toll-like receptors

(2013) Muller Fabbri et al.   RNA Biology

Young and elderly patients with type 2 diabetes have optimal B cell responses to the seasonal influenza vaccine

(2013) Daniela Frasca et al.   VACCINE

Circulating inflamma-miRs in aging and age-related diseases

(2013) Fabiola Olivieri et al.   Frontiers in Genetics

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

(2012) Fabiola Olivieri et al.   AGE

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

(2012) Evelyna Derhovanessian et al.   AGE

Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine

(2012) D. Frasca et al.   INTERNATIONAL IMMUNOLOGY

Lifelong Persistent Viral Infection Alters the Naive T Cell Pool, Impairing CD8 T Cell Immunity in Late Life

(2012) M. J. Smithey et al.   JOURNAL OF IMMUNOLOGY

Ageing and gut microbes: Perspectives for health maintenance and longevity

(2012) Elena Biagi et al.   PHARMACOLOGICAL RESEARCH

Human Cytomegalovirus Entry into Dendritic Cells Occurs via a Macropinocytosis-Like Pathway in a pH-Independent and Cholesterol-Dependent Manner

(2012) Fabienne Haspot et al.   PLoS One

The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

(2012) Janet E. McElhaney et al.   VACCINE

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

(2012) Evelyna Derhovanessian et al.   VACCINE

AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans

(2012) Surender Khurana et al.   PLoS Pathogens

Aging Affects Human B Cell Responses

(2011) Daniela Frasca et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Functional CD8 T Cell Memory Responding to Persistent Latent Infection Is Maintained for Life

(2011) A. Lang et al.   JOURNAL OF IMMUNOLOGY

A Molecular Mechanism for TNF- -Mediated Downregulation of B Cell Responses

(2011) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Age effects on B cells and humoral immunity in humans

(2010) Daniela Frasca et al.   AGEING RESEARCH REVIEWS

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

B cells as under-appreciated mediators of non-auto-immune inflammatory disease

(2010) Barbara S. Nikolajczyk   CYTOKINE

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

(2010) Alexander Panda et al.   JOURNAL OF IMMUNOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2010) Elena Biagi et al.   PLoS One

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans

(2010) Daniela Frasca et al.   VACCINE

The ‘Indirect’ Effects of Cytomegalovirus Infection

(2009) R. B. Freeman et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

(2009) Evelyna Derhovanessian et al.   CURRENT OPINION IN IMMUNOLOGY

The Intestinal Epithelial Barrier: Does It Become Impaired with Age?

(2009) Johannes Meier et al.   DIGESTIVE DISEASES

Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults

(2009) Mirjana Rajilić-Stojanović et al.   ENVIRONMENTAL MICROBIOLOGY

Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-α antagonists

(2009) John D Isaacs   EXPERT OPINION ON BIOLOGICAL THERAPY

Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus

(2009) Wojciech Wojciechowski et al.   IMMUNITY

Modulation of T Lymphocyte Replicative Senescence via TNF-  Inhibition: Role of Caspase-3

(2009) S. T. Parish et al.   JOURNAL OF IMMUNOLOGY

Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice

(2009) Z. Ren et al.   JOURNAL OF MEDICAL MICROBIOLOGY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Influence of aging on murine neutrophil and macrophage function againstCandida albicans

(2008) Celia Murciano et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Obesity and inflammation: the effects of weight loss

(2008) L. Kirsty Forsythe et al.   NUTRITION RESEARCH REVIEWS

Association between LTA, TNF and AGER Polymorphisms and Late Diabetic Complications

(2008) Eero Lindholm et al.   PLoS One

Cytomegalovirus and human immunosenescence

(2008) Graham Pawelec et al.   REVIEWS IN MEDICAL VIROLOGY