RNAs undergo phase transitions with lower critical solution temperatures

Nucleobase Clustering Contributes to the Formation and Hollowing of Repeat-Expansion RNA Condensate

(2022) Yingxue Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning

(2022) Juan M. Iglesias-Artola et al.   Nature Chemistry

Condensates in RNA repeat sequences are heterogeneously organized and exhibit reptation dynamics

(2022) Hung T. Nguyen et al.   Nature Chemistry

Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins

(2022) Xiangze Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thoughts on how to think (and talk) about RNA structure

(2022) Quentin Vicens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conceptual framework for understanding phase separation and addressing open questions and challenges

(2022) Tanja Mittag et al.   MOLECULAR CELL

Elucidation of structure–function relationships in Methanocaldococcus jannaschii RNase P, a multi-subunit catalytic ribonucleoprotein

(2022) Hong-Duc Phan et al.   NUCLEIC ACIDS RESEARCH

Structure–Function Properties in Disordered Condensates

(2021) Kamal Bhandari et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Increased Alu RNA processing in Alzheimer brains is linked to gene expression changes

(2021) Yubo Cheng et al.   EMBO REPORTS

Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures

(2021) Xiangze Zeng et al.   APL Materials

Optimized Magnesium Force Field Parameters for Biomolecular Simulations with Accurate Solvation, Ion-Binding, and Water-Exchange Properties

(2021) Kara K. Grotz et al.   Journal of Chemical Theory and Computation

Uncovering Differences in Hydration Free Energies and Structures for Model Compound Mimics of Charged Side Chains of Amino Acids

(2021) Martin J. Fossat et al.   JOURNAL OF PHYSICAL CHEMISTRY B

It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation

(2021) Hannah J. Wiedner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein cofactors and substrate influence Mg2+-dependent structural changes in the catalytic RNA of archaeal RNase P

(2021) Ila A Marathe et al.   NUCLEIC ACIDS RESEARCH

The many faces of RNA-based RNase P, an RNA-world relic

(2021) Hong-Duc Phan et al.   TRENDS IN BIOCHEMICAL SCIENCES

RNA and liquid-liquid phase separation

(2021) Qi Guo et al.   Non-coding RNA Research

RNA sequence and structure control assembly and function of RNA condensates

(2021) Raghav R. Poudyal et al.   RNA

RNA multimerization as an organizing force for liquid–liquid phase separation

(2021) Philip C. Bevilacqua et al.   RNA

Temperature-dependent reentrant phase transition of RNA–polycation mixtures

(2021) Paul Pullara et al.   Soft Matter

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

(2020) Erik W. Martin et al.   SCIENCE

Mechanisms and Regulation of RNA Condensation in RNP Granule Formation

(2020) Devin Tauber et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamic metastable long-living droplets formed by sticker-spacer proteins

(2020) Srivastav Ranganathan et al.   eLife

Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins

(2020) Xiangze Zeng et al.   BIOPHYSICAL JOURNAL

Analytical Theory for Sequence-Specific Binary Fuzzy Complexes of Charged Intrinsically Disordered Proteins

(2020) Alan N. Amin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

De novo engineering of intracellular condensates using artificial disordered proteins

(2020) Michael Dzuricky et al.   Nature Chemistry

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phase transition of RNA−protein complexes into ordered hollow condensates

(2020) Ibraheem Alshareedah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

(2019) Raghav R. Poudyal et al.   Nature Communications

Light-based control of metabolic flux through assembly of synthetic organelles

(2019) Evan M. Zhao et al.   Nature Chemical Biology

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties

(2019) Steven Boeynaems et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates

(2019) Marina Garcia-Jove Navarro et al.   Nature Communications

Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme

(2019) Futang Wan et al.   Nature Communications

Quantifying Dynamics in Phase-Separated Condensates Using Fluorescence Recovery after Photobleaching

(2019) Nicole O. Taylor et al.   BIOPHYSICAL JOURNAL

Divalent cations can control a switch-like behavior in heterotypic and homotypic RNA coacervates

(2019) Paulo L. Onuchic et al.   Scientific Reports

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

The Role of RNA in Biological Phase Separations

(2018) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

Advances in Understanding Stimulus-Responsive Phase Behavior of Intrinsically Disordered Protein Polymers

(2018) Kiersten M. Ruff et al.   JOURNAL OF MOLECULAR BIOLOGY

Pathway-controlled formation of mesostructured all-DNA colloids and superstructures

(2018) Rémi Merindol et al.   Nature Nanotechnology

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA face of phase separation

(2018) Magdalini Polymenidou   SCIENCE

Abnormal RNA stability in amyotrophic lateral sclerosis

(2018) E. M. Tank et al.   Nature Communications

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

Relation between single-molecule properties and phase behavior of intrinsically disordered proteins

(2018) Gregory L. Dignon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalised RNA catalysis in membrane-free coacervate protocells

(2018) Björn Drobot et al.   Nature Communications

Injectable tissue integrating networks from recombinant polypeptides with tunable order

(2018) Stefan Roberts et al.   NATURE MATERIALS

RNA gets in phase

(2017) Shambaditya Saha et al.   JOURNAL OF CELL BIOLOGY

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions

(2017) Hideki Nakamura et al.   NATURE MATERIALS

The Role of Backbone Hydration of Poly(N-isopropyl acrylamide) Across the Volume Phase Transition Compared to its Monomer

(2017) Moritz H. Futscher et al.   Scientific Reports

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells

(2017) Marta M. Fay et al.   Cell Reports

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

(2017) Tyler S Harmon et al.   eLife

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

(2016) Menglong Zeng et al.   CELL

Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles

(2016) Yi-Hsuan Lin et al.   PHYSICAL REVIEW LETTERS

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Poly(N-isopropylacrylamide) Phase Diagrams: Fifty Years of Research

(2015) Avraham Halperin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly

(2015) Hao Jiang et al.   CELL

Improved Force Field Parameters Lead to a Better Description of RNA Structure

(2015) Christina Bergonzo et al.   Journal of Chemical Theory and Computation

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA World: molecular cooperation at the origins of life

(2014) Paul G. Higgs et al.   NATURE REVIEWS GENETICS

SHAPE-Seq 2.0: systematic optimization and extension of high-throughput chemical probing of RNA secondary structure with next generation sequencing

(2014) David Loughrey et al.   NUCLEIC ACIDS RESEARCH

Why double-stranded RNA resists condensation

(2014) Igor S. Tolokh et al.   NUCLEIC ACIDS RESEARCH

Coarse-Grained Model for Predicting RNA Folding Thermodynamics

(2013) Natalia A. Denesyuk et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Revised AMBER Parameters for Bioorganic Phosphates

(2012) T. Steinbrecher et al.   Journal of Chemical Theory and Computation

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Refinement of the Cornell et al. Nucleic Acids Force Field Based on Reference Quantum Chemical Calculations of Glycosidic Torsion Profiles

(2011) Marie Zgarbová et al.   Journal of Chemical Theory and Computation

Thermophoretic melting curves quantify the conformation and stability of RNA and DNA

(2011) C. J. Wienken et al.   NUCLEIC ACIDS RESEARCH

R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments

(2011) Enguerran Vanquelef et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein L7Ae is a subunit of archaeal RNase P

(2010) I.-M. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Bridging Like-Charged Macroions through Long Divalent Rodlike Ions

(2008) Sylvio May et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Studies on Methanocaldococcus jannaschii RNase P reveal insights into the roles of RNA and protein cofactors in RNase P catalysis

(2008) D. K. Pulukkunat et al.   NUCLEIC ACIDS RESEARCH