Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning

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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

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Analysis of Evolutionarily Independent Protein-RNA Complexes Yields a Criterion to Evaluate the Relevance of Prebiotic Scenarios

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Non-invasive perturbations of intracellular flow reveal physical principles of cell organization

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Impact of macromolecular crowding on RNA/spermine complex coacervation and oligonucleotide compartmentalization

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Compartmentalised RNA catalysis in membrane-free coacervate protocells

(2018) Björn Drobot et al.   Nature Communications

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The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

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Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding

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(2017) Giulio Tesei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

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Coexisting Liquid Phases Underlie Nucleolar Subcompartments

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Polynucleotides in cellular mimics: Coacervates and lipid vesicles

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Growth and division of active droplets provides a model for protocells

(2016) David Zwicker et al.   Nature Physics

A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

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Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

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Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

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Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism

(2015) Bhavesh H. Patel et al.   Nature Chemistry

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

(2015) William M. Aumiller et al.   Nature Chemistry

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

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The Polyelectrolyte Complex/Coacervate Continuum

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Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets

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Phase transitions of multivalent proteins can promote clustering of membrane receptors

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Kinetic Properties of an RNA Enzyme That Undergoes Self-Sustained Exponential Amplification

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The Bacterial Cytoplasm Has Glass-like Properties and Is Fluidized by Metabolic Activity

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Defining the RGG/RG Motif

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Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

(2013) K. Adamala et al.   SCIENCE

Systems of Creation: The Emergence of Life from Nonliving Matter

(2012) Stephen Mann   ACCOUNTS OF CHEMICAL RESEARCH

Thermodynamic Characterization of Polypeptide Complex Coacervation

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Spontaneous network formation among cooperative RNA replicators

(2012) Nilesh Vaidya et al.   NATURE

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Complexation and coacervation of polyelectrolytes with oppositely charged colloids

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Peptide–nucleotide microdroplets as a step towards a membrane-free protocell model

(2011) Shogo Koga et al.   Nature Chemistry

Characterization of the kinetic and thermodynamic landscape of RNA folding using a novel application of isothermal titration calorimetry

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Ribozyme-Catalyzed Transcription of an Active Ribozyme

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Self-Sustained Replication of an RNA Enzyme

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Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

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