Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins
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Title
Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 19, Pages -
Publisher
Proceedings of the National Academy of Sciences
Online
2022-05-06
DOI
10.1073/pnas.2200559119
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Note: Only part of the references are listed.- Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein
- (2022) Pétur O. Heidarsson et al. Nature Chemistry
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- (2021) Xiangze Zeng et al. APL Materials
- Uncovering Differences in Hydration Free Energies and Structures for Model Compound Mimics of Charged Side Chains of Amino Acids
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- Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
- (2021) Cesar L. Cuevas-Velazquez et al. Nature Communications
- Quantifying charge state heterogeneity for proteins with multiple ionizable residues
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- Flanking Disorder of the Folded αα-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution
- (2021) Lasse Staby et al. JOURNAL OF MOLECULAR BIOLOGY
- Single-molecule Detection of Ultrafast Biomolecular Dynamics with Nanophotonics
- (2021) Mark F. Nüesch et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
- (2021) Anne Bremer et al. Nature Chemistry
- Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
- (2021) Giulio Tesei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Controlling Structural Bias in Intrinsically Disordered Proteins Using Solution Space Scanning
- (2020) Alex S. Holehouse et al. Journal of Chemical Theory and Computation
- Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation
- (2020) Jamie A. Greig et al. MOLECULAR CELL
- Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
- (2020) Erik W. Martin et al. SCIENCE
- An analytical theory to describe sequence-specific inter-residue distance profiles for polyampholytes and intrinsically disordered proteins
- (2020) Jonathan Huihui et al. JOURNAL OF CHEMICAL PHYSICS
- Dissecting the Functional Contributions of the Intrinsically Disordered C-terminal Tail of Bacillus subtilis FtsZ
- (2020) Megan C. Cohan et al. JOURNAL OF MOLECULAR BIOLOGY
- Interactions by Disorder – A Matter of Context
- (2020) Katrine Bugge et al. Frontiers in Molecular Biosciences
- Revealing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment
- (2020) David Moses et al. Journal of Physical Chemistry Letters
- Improvements to the ABSINTH forcefield for proteins based on experimentally derived amino-acid specific backbone conformational statistics
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- Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins
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- Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains
- (2019) Szabo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
- (2019) Maksym Tsytlonok et al. Nature Communications
- q-Canonical Monte Carlo Sampling for Modeling the Linkage Between Charge Regulation and Conformational Equilibria of Peptides
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- Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered Proteins Is Regulated through Zinc-Histidine Interactions
- (2019) Carolina Cragnell et al. Biomolecules
- Polymer effects modulate binding affinities in disordered proteins
- (2019) Renee Vancraenenbroeck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Information theoretic measures for quantifying sequence–ensemble relationships of intrinsically disordered proteins
- (2019) Megan C Cohan et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics
- (2019) Charlotte S. Sørensen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Binding without folding – the biomolecular function of disordered polyelectrolyte complexes
- (2019) Benjamin Schuler et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Collapse Transitions of Proteins and the Interplay Among Backbone, Sidechain, and Solvent Interactions
- (2018) Alex S. Holehouse et al. Annual Review of Biophysics
- Intrinsically Disordered Protein Exhibits Both Compaction and Expansion under Macromolecular Crowding
- (2018) Anthony Banks et al. BIOPHYSICAL JOURNAL
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- Sequence charge decoration dictates coil-globule transition in intrinsically disordered proteins
- (2018) Taylor Firman et al. JOURNAL OF CHEMICAL PHYSICS
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- A simple molecular mechanics integrator in mixed rigid body and dihedral angle space
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- Long-Range Correlated Dynamics in Intrinsically Disordered Proteins
- (2014) Giacomo Parigi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells
- (2014) Wade Borcherds et al. Nature Chemical Biology
- Temperature-dependent solvation modulates the dimensions of disordered proteins
- (2014) R. Wuttke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multisteric Regulation by Structural Disorder in Modular Signaling Proteins: An Extension of the Concept of Allostery
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- (2013) Malene Ringkjøbing Jensen et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- A quantitative measure for protein conformational heterogeneity
- (2013) Nicholas Lyle et al. JOURNAL OF CHEMICAL PHYSICS
- Modulation of allostery by protein intrinsic disorder
- (2013) Allan Chris M. Ferreon et al. NATURE
- Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues
- (2013) R. K. Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and α-Synuclein in Solution from NMR and Small Angle Scattering
- (2013) Martin Schwalbe et al. STRUCTURE
- Crystal lattice properties fully determine short-range interaction parameters for alkali and halide ions
- (2012) Albert H. Mao et al. JOURNAL OF CHEMICAL PHYSICS
- Improved Atomistic Monte Carlo Simulations Demonstrate That Poly-l-Proline Adopts Heterogeneous Ensembles of Conformations of Semi-Rigid Segments Interrupted by Kinks
- (2012) Aditya Radhakrishnan et al. JOURNAL OF PHYSICAL CHEMISTRY B
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- (2012) L. Y. Beh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy
- (2012) H. Hofmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of an IDP binding mechanism and rates by helix propensity and non-native interactions: association of HIF1α with CBP
- (2011) David De Sancho et al. Molecular BioSystems
- Sequence Determinants of Compaction in Intrinsically Disordered Proteins
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- Effective Charge and Coil−Globule Transition of a Polyelectrolyte Chain
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- Factors Governing Fibrillogenesis of Polypeptide Chains Revealed by Lattice Models
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- Net charge per residue modulates conformational ensembles of intrinsically disordered proteins
- (2010) A. H. Mao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Charge interactions can dominate the dimensions of intrinsically disordered proteins
- (2010) S. Muller-Spath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Theory of polyzwitterion conformations
- (2009) Rajeev Kumar et al. JOURNAL OF CHEMICAL PHYSICS
- Probing the mechanisms of fibril formation using lattice models
- (2008) Mai Suan Li et al. JOURNAL OF CHEMICAL PHYSICS
- ABSINTH: A new continuum solvation model for simulations of polypeptides in aqueous solutions
- (2008) Andreas Vitalis et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
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