Light-based control of metabolic flux through assembly of synthetic organelles

Current and future modalities of dynamic control in metabolic engineering

(2018) Makoto A Lalwani et al.   CURRENT OPINION IN BIOTECHNOLOGY

Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli

(2018) Kevin W. George et al.   METABOLIC ENGINEERING

Optogenetic regulation of engineered cellular metabolism for microbial chemical production

(2018) Evan M. Zhao et al.   NATURE

Prokaryotic nanocompartments form synthetic organelles in a eukaryote

(2018) Yu Heng Lau et al.   Nature Communications

Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli

(2018) Elliot Dine et al.   Cell Systems

Artificial Protein Scaffold System ( AProSS ): An efficient method to optimize exogenous metabolic pathways in Saccharomyces cerevisiae

(2018) Tianyi Li et al.   METABOLIC ENGINEERING

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2018) Dan Bracha et al.   CELL

Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues

(2017) Agnieszka A. Gil et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harnessing yeast organelles for metabolic engineering

(2017) Sarah K Hammer et al.   Nature Chemical Biology

An artificial transport metabolon facilitates improved substrate utilization in yeast

(2017) Thomas Thomik et al.   Nature Chemical Biology

Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions

(2017) Hideki Nakamura et al.   NATURE MATERIALS

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

A New View into the Regulation of Purine Metabolism: The Purinosome

(2017) Anthony M. Pedley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle

(2017) Youjun Zhang et al.   Nature Communications

Synthetic Protein Scaffolds for Biosynthetic Pathway Colocalization on Lipid Droplet Membranes

(2017) Jyun-Liang Lin et al.   ACS Synthetic Biology

Engineering Cellular Metabolism

(2016) Jens Nielsen et al.   CELL

Spatial colocalization and functional link of purinosomes with mitochondria

(2016) J. B. French et al.   SCIENCE

Towards repurposing the yeast peroxisome for compartmentalizing heterologous metabolic pathways

(2016) William C. DeLoache et al.   Nature Communications

Dynamic knockdown of E. coli central metabolism for redirecting fluxes of primary metabolites

(2015) Irene M. Brockman et al.   METABOLIC ENGINEERING

Cellular compartmentalization of secondary metabolism

(2015) H. Corby Kistler et al.   Frontiers in Microbiology

The Yeast Deletion Collection: A Decade of Functional Genomics

(2014) Guri Giaever et al.   GENETICS

Enzyme clustering accelerates processing of intermediates through metabolic channeling

(2014) Michele Castellana et al.   NATURE BIOTECHNOLOGY

An optimized optogenetic clustering tool for probing protein interaction and function

(2014) Amir Taslimi et al.   Nature Communications

Combinatorial Assembly of Large Biochemical Pathways into Yeast Chromosomes for Improved Production of Value-added Compounds

(2014) Jifeng Yuan et al.   ACS Synthetic Biology

Evaluating the Fitness Cost of Protein Expression in Saccharomyces cerevisiae

(2013) Katarzyna Tomala et al.   Genome Biology and Evolution

Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

(2013) José L Avalos et al.   NATURE BIOTECHNOLOGY

Optogenetic protein clustering and signaling activation in mammalian cells

(2013) Lukasz J Bugaj et al.   NATURE METHODS

Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay

(2013) Michael E. Lee et al.   NUCLEIC ACIDS RESEARCH

A monomeric red fluorescent protein with low cytotoxicity

(2012) I.I. Shemiakina et al.   Nature Communications

Mutational and Structural Studies of the PixD BLUF Output Signal That Affects Light-Regulated Interactions with PixE

(2011) Hua Yuan et al.   BIOCHEMISTRY

The promise of optogenetics in cell biology: interrogating molecular circuits in space and time

(2010) Jared E Toettcher et al.   NATURE METHODS

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation

(2009) R. Narayanaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins

(2008) Katherine S. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PixE promotes dark oligomerization of the BLUF photoreceptor PixD

(2008) H. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA