A Mitocentric View of Alzheimer’s Disease

A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments

(2017) Gary E. Gibson et al.   JOURNAL OF ALZHEIMERS DISEASE

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Shutting down the pore: The search for small molecule inhibitors of the mitochondrial permeability transition

(2016) Justina Šileikytė et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

(2016) Mohammed Akbar et al.   BRAIN RESEARCH

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

(2016) Qing-Fei Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

Mitochondrial FOXO3a is involved in amyloid β peptide-induced mitochondrial dysfunction

(2016) Chun Shi et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

(2016) Chun Shi et al.   JOURNAL OF CELL SCIENCE

Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria

(2016) Shangcheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

(2016) A.M. Bertholet et al.   NEUROBIOLOGY OF DISEASE

Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons

(2016) Mingyue Qu et al.   NEUROCHEMICAL RESEARCH

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

(2016) Lucio G. Costa et al.   Oxidative Medicine and Cellular Longevity

Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer’s Disease

(2016) Beata Pająk et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Alterations in Mitochondrial Quality Control in Alzheimer’s Disease

(2016) Qian Cai et al.   Frontiers in Cellular Neuroscience

Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

(2016) Xinde Zheng et al.   eLife

Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment

(2016) Jaume Folch et al.   NEURAL PLASTICITY

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

Inner membrane fusion mediates spatial distribution of axonal mitochondria

(2016) Yiyi Yu et al.   Scientific Reports

Ion Channel Formation by Tau Protein: Implications for Alzheimer’s Disease and Tauopathies

(2015) Nirav Patel et al.   BIOCHEMISTRY

Mitochondrial fission and fusion

(2015) M. V. Patrushev et al.   BIOCHEMISTRY-MOSCOW

Mitochondrial DNA mutations in neurodegeneration

(2015) Michael J. Keogh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Trends in Mitochondrial Therapeutics for Neurological Disease

(2015) Ana Leitão-Rocha et al.   CURRENT MEDICINAL CHEMISTRY

Preventing the Spread of Alzheimer’s Disease Neuropathology: A Role for Calcilytics?

(2015) Anna Chiarini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Regulation of mitochondrial transport in neurons

(2015) Mei-Yao Lin et al.   EXPERIMENTAL CELL RESEARCH

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Meta-analysis of modifiable risk factors for Alzheimer's disease

(2015) Wei Xu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Mutational mechanisms inMFN2-related neuropathy: compound heterozygosity for recessive and semidominant mutations

(2015) Giuseppe Piscosquito et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Release of mitochondrial Opa1 following oxidative stress in HT22 cells

(2015) Thomas H. Sanderson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

(2015) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model

(2015) Aya Zakaria et al.   MOLECULAR NEUROBIOLOGY

Donepezil attenuates Aβ-associated mitochondrial dysfunction and reduces mitochondrial Aβ accumulation in vivo and in vitro

(2015) Chun Yan Ye et al.   NEUROPHARMACOLOGY

Tau facilitates Aβ-induced loss of mitochondrial membrane potential independent of cytosolic calcium fluxes in mouse cortical neurons

(2015) Susanne P. Pallo et al.   NEUROSCIENCE LETTERS

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Determinants and Functions of Mitochondrial Behavior

(2014) Katherine Labbé et al.   Annual Review of Cell and Developmental Biology

Identification of Human ABAD Inhibitors for Rescuing Aβ-Mediated Mitochondrial Dysfunction

(2014) Koteswara Valaasani et al.   Current Alzheimer Research

A Role for Myosin II in Mammalian Mitochondrial Fission

(2014) Farida Korobova et al.   CURRENT BIOLOGY

Phosphatidic Acid (PA)-preferring Phospholipase A1Regulates Mitochondrial Dynamics

(2014) Takashi Baba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission

(2014) Viviane Richter et al.   JOURNAL OF CELL BIOLOGY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Structure Based Design, Synthesis, Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Novel Cyclophilin D Inhibitors

(2014) Koteswara Rao Valasani et al.   Journal of Chemical Information and Modeling

Interactions of Oxidative Stress and Neurovascular Inflammation in the Pathogenesis of Traumatic Brain Injury

(2014) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer’s disease

(2014) C. Fernandez-Echevarria et al.   NEUROSCIENCE

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

The mitochondrial epigenome: a role in Alzheimer's disease?

(2014) Matthew Devall et al.   Epigenomics

Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

(2014) William F Goure et al.   Alzheimers Research & Therapy

Limitations of Preimplantation Genetic Diagnosis for Mitochondrial DNA Diseases

(2014) Shoukhrat Mitalipov et al.   Cell Reports

Mitochondrial DNA deletions in Alzheimer's brains: A review

(2013) Nicole R. Phillips et al.   Alzheimers & Dementia

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

(2013) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration

(2013) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

Peptide-based carbon nanotubes for mitochondrial targeting

(2013) Alessia Battigelli et al.   Nanoscale

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

(2013) Sandra R Bacman et al.   NATURE MEDICINE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1−42 on neural progenitor cell proliferation

(2013) Yan Hou et al.   NEUROBIOLOGY OF AGING

Involvement of cysteinyl leukotriene receptor 1 in Aβ1–42-induced neurotoxicity in vitro and in vivo

(2013) Su-Su Tang et al.   NEUROBIOLOGY OF AGING

A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats

(2013) Nanchang Xie et al.   NEUROSCIENCE LETTERS

A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats

(2013) Ning Zhang et al.   NEUROSCIENCE LETTERS

Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

(2013) Vega García-Escudero et al.   Oxidative Medicine and Cellular Longevity

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial disorders: aetiologies, models systems, and candidate therapies

(2013) G. Jane Farrar et al.   TRENDS IN GENETICS

Why size matters – balancing mitochondrial dynamics in Alzheimer's disease

(2013) Brian DuBoff et al.   TRENDS IN NEUROSCIENCES

Mechanisms of Mitochondrial Fission and Fusion

(2013) A. M. van der Bliek et al.   Cold Spring Harbor Perspectives in Biology

Alternative Oxidase Expression in the Mouse Enables Bypassing Cytochrome c Oxidase Blockade and Limits Mitochondrial ROS Overproduction

(2013) Riyad El-Khoury et al.   PLoS Genetics

Synaptic Activity and Bioenergy Homeostasis: Implications in Brain Trauma and Neurodegenerative Diseases

(2013) Natasha Khatri et al.   Frontiers in Neurology

Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis

(2012) Katja Scheffler et al.   ACTA NEUROPATHOLOGICA

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?

(2012) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Proteolytic control of mitochondrial function and morphogenesis

(2012) Ruchika Anand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy

(2012) Jone López-Erauskin et al.   BRAIN

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

(2012) Nambirajan Govindarajan et al.   EMBO Molecular Medicine

Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice

(2012) Magali Dumont et al.   HUMAN MOLECULAR GENETICS

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Towards germline gene therapy of inherited mitochondrial diseases

(2012) Masahito Tachibana et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons

(2012) Chaeyoung Kim et al.   PLoS One

Mitochondrial Superoxide Production Negatively Regulates Neural Progenitor Proliferation and Cerebral Cortical Development

(2012) Yan Hou et al.   STEM CELLS

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics and neuronal synaptic damage in neurodegenerative diseases

(2011) T Nakamura et al.   CELL DEATH AND DIFFERENTIATION

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

(2011) E C Ferber et al.   CELL DEATH AND DIFFERENTIATION

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

(2011) Susanne M. Pritchard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Impaired Attention in the 3xTgAD Mouse Model of Alzheimer's Disease: Rescue by Donepezil (Aricept)

(2011) C. Romberg et al.   JOURNAL OF NEUROSCIENCE

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

(2011) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF AGING

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

Inhibition of the Mitochondrial Enzyme ABAD Restores the Amyloid-β-Mediated Deregulation of Estradiol

(2011) Yun-An Lim et al.   PLoS One

Evolution of the mitochondrial fusion-fission cycle and its role in aging

(2011) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

(2010) Robin A.J. Smith et al.   Annals of the New York Academy of Sciences

Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization

(2010) Sylvie Montessuit et al.   CELL

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease

(2010) D. Allan Butterfield et al.   FREE RADICAL RESEARCH

Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex

(2010) A. Misko et al.   JOURNAL OF NEUROSCIENCE

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort

(2010) Anita Lakatos et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA