The mitochondrial epigenome: a role in Alzheimer's disease?

Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key?

(2017) Maria Ankarcrona et al.   JOURNAL OF ALZHEIMERS DISEASE

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

(2014) Daniel Condliffe et al.   NEUROBIOLOGY OF AGING

Defective Mitochondrial Function In Vivo in Skeletal Muscle in Adults with Down’s Syndrome: A 31P-MRS Study

(2014) Alexander C. Phillips et al.   PLoS One

Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies

(2013) Katie Lunnon et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

DNA Methylation as a Biomarker for Preeclampsia

(2013) C. M. Anderson et al.   Biological Research for Nursing

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

(2013) Jose V. Sanchez-Mut et al.   BRAIN

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern

(2013) D. Bellizzi et al.   DNA RESEARCH

A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

(2013) Juan Sandoval et al.   JOURNAL OF CLINICAL ONCOLOGY

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool

(2013) Vito Iacobazzi et al.   MOLECULAR GENETICS AND METABOLISM

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine

(2013) Michael J Booth et al.   Nature Protocols

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation

(2013) Milena Pinto et al.   NEUROBIOLOGY OF AGING

Activity and metabolism-related Ca2+ and mitochondrial dynamics in co-cultured human fetal cortical neurons and astrocytes

(2013) W. Fu et al.   NEUROSCIENCE

Effects of airborne pollutants on mitochondrial DNA Methylation

(2013) Hyang-Min Byun et al.   Particle and Fibre Toxicology

Decrease of 5-Hydroxymethylcytosine Is Associated with Progression of Hepatocellular Carcinoma through Downregulation of TET1

(2013) Chungang Liu et al.   PLoS One

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcytosine in Mouse Embryonic Stem Cells

(2013) Zhiyi Sun et al.   Cell Reports

DNA methylation based biomarkers: Practical considerations and applications

(2012) Alexandre How Kit et al.   BIOCHIMIE

Primates and mouse NumtS in the UCSC Genome Browser

(2012) Francesco Maria Calabrese et al.   BMC BIOINFORMATICS

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells

(2012) Jan Tauber et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epigenetics, epidemiology and mitochondrial DNA diseases

(2012) Patrick F Chinnery et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Effect of aging on 5-hydroxymethylcytosine in brain mitochondria

(2012) Svetlana Dzitoyeva et al.   NEUROBIOLOGY OF AGING

A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip® for Methylome Profiling

(2012) Christine Clark et al.   PLoS One

Global DNA methylation levels are modulated by mitochondrial DNA variants

(2012) Dina Bellizzi et al.   Epigenomics

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

(2012) Matthew N Davies et al.   GENOME BIOLOGY

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

(2011) Latha Devi et al.   NEUROBIOLOGY OF DISEASE

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High levels of mitochondrial heteroplasmy modify the development of ovine - bovine interspecies nuclear transferred embryos

(2011) Song Hua et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA

(2010) Colm Nestor et al.   BIOTECHNIQUES

DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions

(2010) Masaki Takasugi et al.   BMC GENOMICS

A novel role for mitochondria in regulating epigenetic modifications in the nucleus

(2010) Dominic Smiraglia et al.   CANCER BIOLOGY & THERAPY

Mitochondrial control of caspase-dependent and -independent cell death

(2010) Ludivine A. Pradelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome

(2010) Vittoria Infantino et al.   MOLECULAR GENETICS AND METABOLISM

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Method to purify mitochondrial DNA directly from yeast total DNA

(2010) Jingwen Zhou et al.   PLASMID

Ancient mitogenomics

(2009) Simon Y.W. Ho et al.   MITOCHONDRION

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions

(2009) Adriana P. Rebelo et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One

The Colorful History of Active DNA Demethylation

(2008) Steen K.T. Ooi et al.   CELL

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mitochondrial haplogroup H and Alzheimer's disease—Is there a connection?

(2008) Aleksandra Maruszak et al.   NEUROBIOLOGY OF AGING

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Many species in one: DNA barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified

(2008) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA