Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer’s Disease

(2015) Domenico Nuzzo et al.   Current Alzheimer Research

HDAC2 Selectively Regulates FOXO3a-Mediated Gene Transcription during Oxidative Stress-Induced Neuronal Cell Death

(2015) S. Peng et al.   JOURNAL OF NEUROSCIENCE

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease

(2015) Woo-Joo Song et al.   PLoS One

Cdk5 activity in the brain - multiple paths of regulation

(2014) K. Shah et al.   JOURNAL OF CELL SCIENCE

Ischemic Stroke Injury Is Mediated by Aberrant Cdk5

(2014) D. A. Meyer et al.   JOURNAL OF NEUROSCIENCE

FoxO mediates APP-induced AICD-dependent cell death

(2014) X Wang et al.   Cell Death & Disease

WISP1 Neuroprotection Requires FoxO3a Post-Translational Modulation with Autoregulatory Control of SIRT1

(2013) Shaohui Wang et al.   CURRENT NEUROVASCULAR RESEARCH

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

(2013) Romina María Uranga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Chronic Excitotoxin-Induced Axon Degeneration in a Compartmented Neuronal Culture Model

(2012) Katherine A Hosie et al.   ASN Neuro

LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy

(2012) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

(2012) K.-H. Chang et al.   JOURNAL OF CELL SCIENCE

PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

(2011) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity

(2011) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

(2011) Kuei-Hua Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Collapsin Response Mediator Protein-2: An Emerging Pathologic Feature and Therapeutic Target for Neurodisease Indications

(2011) Kenneth Hensley et al.   MOLECULAR NEUROBIOLOGY

Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer's Disease-type Amyloid Neuropathology and Spatial Memory Deterioration

(2010) Weiping Qin et al.   Annals of the New York Academy of Sciences

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease

(2010) Kuei-Hua Chang et al.   JOURNAL OF NEUROCHEMISTRY

Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

(2010) Shin-ichi Hisanaga et al.   JOURNAL OF NEUROCHEMISTRY

Glycogen synthase kinase-3β and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

(2010) M. Morel et al.   NEUROSCIENCE

Activated Actin-Depolymerizing Factor/Cofilin Sequesters Phosphorylated Microtubule-Associated Protein during the Assembly of Alzheimer-Like Neuritic Cytoskeletal Striations

(2009) I. T. Whiteman et al.   JOURNAL OF NEUROSCIENCE

Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH2-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease

(2009) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription

(2008) Beibei Cai et al.   APOPTOSIS

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

(2008) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease

(2008) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Neuronal Death by Oxidative Stress Involves Activation of FOXO3 through a Two-Arm Pathway That Activates Stress Kinases and Attenuates Insulin-like Growth Factor I Signaling

(2008) David Dávila et al.   MOLECULAR BIOLOGY OF THE CELL

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

The FoxO code

(2008) D R Calnan et al.   ONCOGENE