Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry

New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT1A Receptor Agents

(2023) Kinga Ostrowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-aging effect of methylurolithin A and its amide derivatives on nematode Caenorhabditis elegans

(2023) Long Tang et al.   TETRAHEDRON LETTERS

Tetramethylpyrazine-Rhein Derivative inhibits the migration of canine inflammatory mammary carcinoma cells by mitochondrial damage-mediated apoptosis and cadherins downregulation

(2023) Xinqiu Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Selinexor in patients with advanced and recurrent endometrial cancer

(2023) Giorgio Bogani et al.   CURRENT PROBLEMS IN CANCER

Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors

(2023) Roberta Bivacqua et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of pyrrolo[3′,4’:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

(2023) Marilia Barreca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and anti-aging effect evaluation of urolithin B and its amide derivatives on nematode Caenorhabditis elegans

(2023) Xi Chen et al.   MEDICINAL CHEMISTRY RESEARCH

Ligustrazine-Derived Chalcones-Modified Platinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancer through Ferroptosis and Apoptosis

(2023) Meng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles

(2022) Wentao Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acipimox inhibits human carbonic anhydrases

(2022) Mattia Mori et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery

(2022) Robert W. Huigens et al.   MOLECULES

S2k guideline: Rosacea

(2022) Benjamin M. Clanner‐Engelshofen et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Synthesis and Antiproliferative Activity of Novel Dehydroabietic Acid-Chalcone Hybrids

(2022) Sophia Grigoropoulou et al.   MOLECULES

Advances in the Synthesis and Bio-Applications of Pyrazine Derivatives: A Review

(2022) Dimple Choudhary et al.   POLYCYCLIC AROMATIC COMPOUNDS

Site-Selectivity of the Reaction of 3-Amino-4-Cyano-5-Phenyl-1H-Pyrrole-2-Carboxylic Acid Amide with α-Halocarbonyl Compounds. Antimicrobial Activity and Docking Study for COVID-19 of the Products

(2022) Ghada S. Masaret et al.   POLYCYCLIC AROMATIC COMPOUNDS

Triterpenoid pyrazines and pyridines – Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs

(2022) Jiří Hodoň et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pralatrexate mediates effective killing of gemcitabine-resistant pancreatic cancer: role of mTOR/4E-BP1 signal pathway

(2022) Wanwen Weng et al.   Heliyon

Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible Nitric Oxide Synthase dimerization inhibitor with efficacy for arthritis

(2021) Liu Zeng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Elbasvir and grazoprevir for the treatment of hepatitis C

(2021) Szu-Jen Wang et al.   Expert Review of Anti-Infective Therapy

Synthesis and anticancer activity of chalcone–quinoxalin conjugates

(2021) Xiaoyun Ma et al.   SYNTHETIC COMMUNICATIONS

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

(2021) Hayato Mizuta et al.   Nature Communications

Synthesis and biological evaluation of pentacyclic triterpenoid derivatives as potential novel antibacterial agents

(2021) Panpan Wu et al.   BIOORGANIC CHEMISTRY

Mixed-Ligand Cobalt(III) Complexes of a Naturally Occurring Coumarin and Phenanthroline Bases as Mitochondria-Targeted Dual-Purpose Photochemotherapeutics

(2021) Tukki Sarkar et al.   INORGANIC CHEMISTRY

Design, synthesis, anticancer evaluation and molecular docking studies of chalcone linked pyrido[4,3-b]pyrazin-5(6H)-one derivatives

(2021) Dandamudi Srilaxmi et al.   JOURNAL OF MOLECULAR STRUCTURE

Application of Amino Acids in the Structural Modification of Natural Products: A Review

(2021) Qian Xu et al.   Frontiers in Chemistry

Synthesis and biological evaluation of novel ligustrazine-chalcone derivatives as potential anti-triple negative breast cancer agents

(2021) Yingqi Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors

(2021) Hao Yang et al.   BIOORGANIC CHEMISTRY

Favipiravir for the treatment of patients with COVID-19: a systematic review and meta-analysis

(2021) Toshie Manabe et al.   BMC INFECTIOUS DISEASES

Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug

(2021) Zahir Hussain et al.   DRUG METABOLISM AND DISPOSITION

Copper(II) Complexes Containing Natural Flavonoid Pomiferin Show Considerable In Vitro Cytotoxicity and Anti-inflammatory Effects

(2021) Ján Vančo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenazine-1-carboxylic Acid Produced by Pseudomonas chlororaphis YL-1 Is Effective against Acidovorax citrulli

(2021) Youzhou Liu et al.   Microorganisms

Tanshinone IIA: Pharmacology, total synthesis, and progress in structure-modifications

(2021) Xing Huang et al.   CURRENT MEDICINAL CHEMISTRY

A Derivative of Piperlongumine and Ligustrazine as a Potential Thioredoxin Reductase Inhibitor in Drug-Resistant Hepatocellular Carcinoma

(2021) Jianqiang Qian et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

(2020) Fengyi Zhao et al.   DRUG DELIVERY

Design, Synthesis, and Biological Evaluation of Two Series of Novel A-Ring Fused Steroidal Pyrazines as Potential Anticancer Agents

(2020) Shijun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modified Quinoxaline‐Fused Oleanolic Acid Derivatives as Inhibitors of Osteoclastogenesis and Potential Agent in Anti‐Osteoporosis

(2020) Yu‐Chao Zhang et al.   ChemistrySelect

Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition

(2020) Sivaraman Balasubramaniam et al.   Beilstein Journal of Organic Chemistry

Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo

(2020) Yang Sheng Hu et al.   BIOORGANIC CHEMISTRY

Synthesis, antimicrobial and chitinase inhibitory activities of 3-amidocoumarins

(2020) Rajesh Kumar Sharma et al.   BIOORGANIC CHEMISTRY

Synthesis, anti-microbial and anti-inflammatory activities of 18β-glycyrrhetinic acid derivatives

(2020) Yang Yang et al.   BIOORGANIC CHEMISTRY

2-Pyrazine-PPD, a novel dammarane derivative, showed anticancer activity by reactive oxygen species-mediate apoptosis and endoplasmic reticulum stress in gastric cancer cells

(2020) Xu De Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ni(II) curcumin complexes for cellular imaging and photo-triggered in vitro anticancer activity

(2020) Atrayee Banaspati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity

(2020) Binghua Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of ortho-naphthoquinones as anti-AML agents by highly efficient oxidation of phenols

(2019) Huidan Huang et al.   BIOORGANIC CHEMISTRY

Synthesis of new boswellic acid derivatives as potential antiproliferative agents

(2019) Umair Shamraiz et al.   NATURAL PRODUCT RESEARCH

Effect of the formation of silver nano‐binuclear complex on the refinement of cytotoxic and antibacterial potency of coumarin Schiff base: Spectroscopy, thermal, X‐ray diffraction analyses and density functional theory calculations

(2019) Aida L. El‐Ansary et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity

(2019) Uday Kiran Velagapudi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Structure Elucidation, Homology Modeling and Antifilarial Activity of 7‐Benzamidocoumarin Derivatives

(2019) Priyanka et al.   ChemistrySelect

Antimicrobial evaluation and action mechanism of chalcone derivatives containing quinoxaline moiety

(2019) Rongjiao Xia et al.   MONATSHEFTE FUR CHEMIE

A reduction‐responsive amphiphilic methotrexate‐podophyllotoxin conjugate for targeted chemotherapy

(2019) Meili Hou et al.   Chemistry-An Asian Journal

Hybrid molecules of scutellarein and tertramethylpyrazine’s active metabolites for ischemic stroke

(2019) Yongxi Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes

(2019) Stephen Barrett et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Synthesis, structure and in vitro biological evaluation of new lupane and dammarane triterpenoids fused with pyrazine heterocycle

(2019) Alla D. Zorina et al.   MENDELEEV COMMUNICATIONS

Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer’s disease agents

(2019) Gui-Xiang Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect

(2019) Wen-Xi Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel, potent, isosteviol-based antithrombotic agents

(2019) Peng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents

(2019) Wen-Bo Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nucleus targeting anthraquinone-based copper (II) complexes as the potent PDT agents: Synthesis, photo-physical and theoretical evaluation

(2019) Longjam Reena Devi et al.   INORGANICA CHIMICA ACTA

Synthesis, in vitro cytotoxicity activity against the human cervix carcinoma cell line and in silico computational predictions of new 4-arylamino-3-nitrocoumarin analogues

(2019) Ahmed H. Halawa et al.   JOURNAL OF MOLECULAR STRUCTURE

Erdafitinib for the treatment of metastatic bladder cancer

(2019) Kamaneh Montazeri et al.   Expert Review of Clinical Pharmacology

Functional and Structural Analysis of Phenazine O-Methyltransferase LaPhzM from Lysobacter antibioticus OH13 and One-Pot Enzymatic Synthesis of the Antibiotic Myxin

(2018) Jiasong Jiang et al.   ACS Chemical Biology

2-Substituted-1-(2-morpholinoethyl)-1 H -naphtho[2,3- d ]imidazole-4,9-diones: Design, synthesis and antiproliferative activity

(2018) Zhanxiong Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroprotection by new ligustrazine-cinnamon acid derivatives on CoCl 2 -induced apoptosis in differentiated PC12 cells

(2018) Penglong Wang et al.   BIOORGANIC CHEMISTRY

A Gold(III) Pincer Ligand Scaffold for the Synthesis of Binuclear and Bioconjugated Complexes: Synthesis and Anticancer Potential

(2018) Benoît Bertrand et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and activity towards Alzheimer's disease in vitro : Tacrine, phenolic acid and ligustrazine hybrids

(2018) Guoliang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors

(2018) Qian Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents

(2018) Gao-Rong Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes

(2018) Stephen Barrett et al.   INORGANICA CHIMICA ACTA

Novel Ligustrazine-Based Analogs of Piperlongumine Potently Suppress Proliferation and Metastasis of Colorectal Cancer Cells in Vitro and in Vivo

(2018) Yu Zou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Folic acid and primary prevention of neural tube defects: A review

(2018) Jan D. van Gool et al.   REPRODUCTIVE TOXICOLOGY

Regioselective synthesis of 2,3-disubstituted 1-alkyl pyrrolo[2,3- b ] quinoxalines through palladium-catalyzed Heck reaction of chalcones and evaluation of their anti-bacterial activities

(2018) Tayebeh Besharati-Seidani et al.   TETRAHEDRON

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

(2018) Yanting Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transcript Profiling of MRSA Biofilms Treated with a Halogenated Phenazine Eradicating Agent: A Platform for Defining Cellular Targets and Pathways Critical to Biofilm Survival

(2018) Yasmeen Abouelhassan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents

(2018) Hui Wang et al.   MOLECULES

Development of a Synthesis of Kinase Inhibitor AKN028

(2018) Ulf Bremberg et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents

(2018) Xiao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Brimonidine tartrate for the treatment of glaucoma

(2018) Daniel J. Oh et al.   EXPERT OPINION ON PHARMACOTHERAPY

Synthesis and biological evaluation of novel oleanolic acid analogues as potential α-glucosidase inhibitors

(2018) Ying-Ying Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combination of amino acid/dipeptide with ligustrazine-betulinic acid as antitumor agents

(2017) Bing Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of N -heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents

(2017) Yu Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitors

(2017) Elmira F. Khusnutdinova et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugates

(2017) Pathi Suman et al.   TETRAHEDRON

Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors

(2017) Pan-Pan Wu et al.   Scientific Reports

Aromatic heterocyclic esters of podophyllotoxin exert anti-MDR activity in human leukemia K562/ADR cells via ROS/MAPK signaling pathways

(2016) Lei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers

(2016) Mostafa M. Ghorab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents

(2016) Hai-Wei Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of New Monocarbonyl Ligustrazine–Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer

(2016) Yong Ai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and characterization of acetic acid functionalized poly (4-vinylpyridinium) salt as new catalyst for the synthesis of spiropyran derivatives and their biological activity

(2016) Ahmad Reza Moosavi-Zare et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Pyridine-catalyzed synthesis of quinoxalines as anticancer and anti-tubercular agents

(2016) Atulkumar A. Kamble et al.   MEDICINAL CHEMISTRY RESEARCH

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Design, synthesis and anticancer activities of novel otobain derivatives

(2016) Zhongzhou Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents

(2016) Amélie Talbot et al.   STEROIDS

Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives

(2016) Anton Ivanov et al.   RSC Advances

Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin

(2015) Miroslav Soural et al.   BIOCONJUGATE CHEMISTRY

Ligustrazinyl amides: a novel class of ligustrazine-phenolic acid derivatives with neuroprotective effects

(2015) Guoliang Li et al.   Chemistry Central Journal

Remarkable enhancement in photocytotoxicity and hydrolytic stability of curcumin on binding to an oxovanadium(iv) moiety

(2015) Samya Banerjee et al.   DALTON TRANSACTIONS

Antiproliferative, DNA intercalation and redox cycling activities of dioxonaphtho[2,3-d]imidazolium analogs of YM155: A structure–activity relationship study

(2015) Si-Han Sherman Ho et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antitumor activity of triterpenoid pyrazine derivatives from 23-hydroxybetulinic acid

(2015) Hengyuan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design, Synthesis, and Biological Evaluation

(2015) Bing Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

(2015) Muthu Shanmugam et al.   MOLECULES

Selexipag for the Treatment of Pulmonary Arterial Hypertension

(2015) Olivier Sitbon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

(2015) Richa Goel et al.   RSC Advances

Synthesis andIn VitroBiological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds

(2015) Amaç Fatih Tuyun et al.   Journal of Chemistry

Indole Alkaloids from Alocasia macrorrhiza

(2015) Ling-hua Zhu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Zibotentan

(2015) N.D. James et al.   DRUGS OF THE FUTURE

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

(2015) Pankaj Miniyar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis and Antitumor Evaluation of One Novel Tetramethylpyrazine-Rhein Derivative

(2014)   ASIAN JOURNAL OF CHEMISTRY

Folate Receptor-Mediated Enhanced and Specific Delivery of Far-Red Light-Activatable Prodrugs of Combretastatin A-4 to FR-Positive Tumor

(2014) Gregory Nkepang et al.   BIOCONJUGATE CHEMISTRY

A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation

(2014) Wei Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of new heterocyclic lupeol derivatives as nitric oxide and pro-inflammatory cytokine inhibitors

(2014) Pamita Bhandari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and insecticidal activity of new oxime derivatives of podophyllotoxin-based phenazines against Mythimna separata Walker

(2014) Xiaoyan Zhi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives

(2014) Shengtao Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 4β-acyloxypodophyllotoxin analogs modified in the C and E rings as insecticidal agents against Mythimna separata Walker

(2014) Xiaoyan Zhi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of Second-Generation Small-Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy

(2014) Sheng Ma et al.   ChemMedChem

Bortezomib in multiple myeloma: systematic review and clinical considerations

(2014) T.C. Kouroukis et al.   Current Oncology

Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives

(2014) Shengtao Xu et al.   FITOTERAPIA

Tryptophan Hydroxylase 1 (Tph-1)-Targeted Bone Anabolic Agents for Osteoporosis

(2014) Hai-Jian Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents

(2014) Fuhao Chu et al.   MOLECULES

Synthesis and biological evaluation of T-OA analogues as the cytotoxic agents

(2014) Kuo Xu et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Regio-controlled synthesis of unsymmetrical pyrazine-fused sinomenine derivatives and discriminate substitution effects on TNF-α inhibitory activity

(2014) Tingting Zhou et al.   TETRAHEDRON

Design, synthesis and biological evaluation of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids as potent cardiovascular agents

(2014) Hongfei Chen et al.   MedChemComm

4-Chlorocolchicine derivatives bearing a thiourea side chain at the C-7 position as potent anticancer agents

(2014) Hiroyuki Nishiyama et al.   MedChemComm

Heterocycle-fused lupane triterpenoids inhibit Leishmania donovani amastigotes

(2014) Raisa Haavikko et al.   MedChemComm

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

(2014) Toshihiro Aoki et al.   ACS Medicinal Chemistry Letters

Fluorescent Probes for Subcellular Localization during Osteclast Formation

(2014) Jing Wu et al.   ACS Medicinal Chemistry Letters

Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment

(2013) Håvard Sletta et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Discovery of novel andrographolide derivatives as cytotoxic agents

(2013) Shanfu Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide

(2013) Hongtao Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Insecticidal Activity of New Deoxypodophyllotoxin-Based Phenazine Analogues against Mythimna separata Walker

(2013) Juanjuan Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis and antifungal activity of novel 7-O-substituted pyridyl-4-methyl coumarin derivatives

(2013) Xiaoyun Chai et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis and biological evaluation of novel ligustrazinylated derivatives as potent cardiovascular agents

(2013) Hongfei Chen et al.   MedChemComm

Synthesis, structure–activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents

(2012) Li-Jun Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of a folate-targeted rhaponticin conjugate

(2012) Xuhua Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ligustrazine Derivatives. Part 4: Design, Synthesis, and Biological Evaluation of Novel Ligustrazine-based Stilbene Derivatives as Potential Cardiovascular Agents

(2012) Lijuan Deng et al.   Chemical Biology & Drug Design

Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(iv) complex formation

(2012) Samya Banerjee et al.   CHEMICAL COMMUNICATIONS

Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors

(2012) Alberto Bargiotti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural products-based insecticidal agents 13. Semisynthesis and insecticidal activity of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring against Mythimna separata Walker in vivo

(2012) Xiao-yan Zhi et al.   INDUSTRIAL CROPS AND PRODUCTS

Synthesis and Biological Evaluation of Heterocyclic Ring-Fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption

(2012) Jun Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of a New pH-Sensitive Folate–Doxorubicin Conjugate and its Antitumor Activity In Vitro

(2012) Wei-Liang Ye et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and Biological Evaluation of New Ligustrazine Derivatives as Anti-Tumor Agents

(2012) Penglong Wang et al.   MOLECULES

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

(2012) A Eriksson et al.   Blood Cancer Journal

From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons

(2011) Pierre L. Beaulieu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Utility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-Glycoprotein

(2011) M. Iwai et al.   DRUG METABOLISM AND DISPOSITION

Ligustrazine derivatives. Part 5: Design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents

(2011) Hongfei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Telaprevir for the treatment of chronic hepatitis C infection

(2011) Andrew J Muir   Expert Review of Anti-Infective Therapy

Design and Synthesis of Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases?

(2011) Jing Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opioid Activity of Spinally Selective Analogues of N-Naphthoyl-β-naltrexamine in HEK-293 Cells and Mice

(2011) Morgan Le Naour et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-naphthoyl- -naltrexamine (NNTA), a highly selective and potent activator of  / -opioid heteromers

(2011) A. S. Yekkirala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, Synthesis, and Cytotoxicity of Indolizinoquinoxaline-5,12-dione Derivatives, Novel DNA Topoisomerase IB Inhibitors

(2010) De-Qing Shen et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives

(2010) Karem Shanab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potential Chemopreventive Agents Based on the Structure of the Lead Compound 2-Bromo-1-hydroxyphenazine, Isolated fromStreptomycesSpecies, Strain CNS284

(2010) Martin Conda-Sheridan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modified Phenazines from an IndonesianStreptomycessp.†

(2010) Serge Fotso et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of novel steroidal oxazolo quinoxaline as antibacterial agents

(2010) Salman Ahmad Khan et al.   Arabian Journal of Chemistry

Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues

(2009) Hsu-Shan Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

(2009) Wen-Wei Qiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines†† This review is dedicated to the community of isolation/identification natural product detectives, with special thanks to the groups of Bob Pettit and Nobuhiro Fusatani.

(2009) Seongmin Lee et al.   CHEMICAL REVIEWS

Bortezomib

(2009) Monique P. Curran et al.   DRUGS

Synthesis and evaluation of a novel series of heterocyclic oleanolic acid derivatives with anti-osteoclast formation activity

(2009) Jun-Feng Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid

(2009) Ramendra K. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode†

(2009) Kevin Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro evaluation of botryllazine B analogues as a new class of inhibitor against human aldose reductase

(2009) Ryota Saito et al.   TETRAHEDRON

Modification of poorly bioactive sinomenine into more potent immunosuppressive agents by embedding of drug-like fragments

(2009) Yang-Tong Lou et al.   TETRAHEDRON LETTERS

Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-triazacyclopenta[b]anthracene-5,10-diones

(2008) Jae-Hwan Kwak et al.   ARCHIVES OF PHARMACAL RESEARCH

3D-QSAR studies of heterocyclic quinones with inhibitory activity on vascular smooth muscle cell proliferation using pharmacophore-based alignment

(2008) Chung-Kyu Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B

(2008) Shahar Keinan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase

(2008) Christophe Morin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity

(2008) Mark M. Foreman et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Synthesis, structure elucidation and antibacterial evaluation of new steroidal -5-en-7-thiazoloquinoxaline derivatives

(2007) Salman Ahmad Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline

(2007) Salman A. Khan   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY