4-Chlorocolchicine derivatives bearing a thiourea side chain at the C-7 position as potent anticancer agents

Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

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Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges

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Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B

(2011) Naoko Yasobu et al.   ACS Medicinal Chemistry Letters

Syntheses and biological evaluation of ring-C modified colchicine analogs

(2010) Baiyuan Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors

(2010) Chih-Ying Nien et al.   JOURNAL OF MEDICINAL CHEMISTRY

Primary Endothelial Damage Is the Mechanism of Cardiotoxicity of Tubulin-Binding Drugs

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