A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design, Synthesis, and Biological Evaluation

Synthesis of oleanolic acid dimers linked at C-28 and evaluation of anti-tumor activity

(2015) Ke-Guang Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of triazole linked glycosylated 18β-glycyrrhetinic acid derivatives as anticancer agents

(2014) Pravat Kumar Parida et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells

(2014) Junho Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Betulinic Acid-Induced Cytotoxicity in Human Breast Tumor Cell Lines MCF-7 and T47D and its Modification by Tocopherol

(2014) Reeta Tiwari et al.   CANCER INVESTIGATION

Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence

(2014) Muthu K. Shanmugam et al.   CANCER LETTERS

Biological activities of green silver nanoparticles synthesized with Acorous calamus rhizome extract

(2014) Jayachandra Reddy Nakkala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combination of Amino Acid/Dipeptide with Nitric Oxide Donating Oleanolic Acid Derivatives as PepT1 Targeting Antitumor Prodrugs

(2014) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissymmetric thiosemicarbazone ligands containing substituted aldehyde arm and their ruthenium(II) carbonyl complexes with PPh3/AsPh3 as ancillary ligands: Synthesis, structural characterization, DNA/BSA interaction and in vitro anticancer activity

(2014) Paranthaman Vijayan et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters

(2014) Luciana Costa et al.   PLoS One

Preparation and Evaluation of Solid Dispersions of A New Antitumor Compound Based on Early-Stage Preparation Discovery Concept

(2013) Peng Hou et al.   AAPS PHARMSCITECH

Betulin-Betulinic Acid Natural Product Based Analogs as Anti-Cancer Agents

(2013) Subash Jonnalagadda et al.   Anti-Cancer Agents in Medicinal Chemistry

Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV–VIS broadband radiation

(2013) Yuan-Hao Lee et al.   APOPTOSIS

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti-cancer drugs

(2013) Ahmed Ashour et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells

(2013) Oksana V. Salomatina et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK–p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

(2013) Xin Wang et al.   CARCINOGENESIS

Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin – An in vitro and in silico approach

(2013) Kumaravel Mohankumar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In-vitroandin-vivocomparison of T-OA microemulsions and solid dispersions based on EPDC

(2013) Peng Hou et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents

(2013) Showkat Rashid et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A “natural” approach: Synthesis and cytoxicity of monodesmosidic glycyrrhetinic acid glycosides

(2013) Stefan Schwarz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pronounced transcriptional regulation of apoptotic and TNF–NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells

(2013) Cagri Sakalar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

(2013) Penglong Wang et al.   MOLECULES

The role of lipophilicity in transmembrane anion transport

(2012) Vittorio Saggiomo et al.   CHEMICAL COMMUNICATIONS

Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells

(2012) Xi Chen et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ligustrazine Derivatives. Part 6: Design, Synthesis and Evaluation of Novel Ligustrazinyl Acylguanidine Derivatives as Potential Cardiovascular Agents

(2012) Zhenyu Li et al.   Medicinal Chemistry

Synthesis and Biological Evaluation of New Ligustrazine Derivatives as Anti-Tumor Agents

(2012) Penglong Wang et al.   MOLECULES

Synthesis and Cytotoxic Activity of Methyl Glycyrrhetinate Esterified with Amino Acids

(2012) René Csuk et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Improvement of the Cytotoxicity and Tumor Selectivity of Glycyrrhetinic Acid by Derivatization with Bifunctional Aminoacids

(2011) René Csuk et al.   ARCHIV DER PHARMAZIE

Betulinic acid, a natural compound with potent anticancer effects

(2010) Franziska B. Mullauer et al.   ANTI-CANCER DRUGS

Synthesis and antitumour activity of glycyrrhetinic acid derivatives

(2010) Stefan Schwarz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and NO Production Inhibitory Activities of Ursolic Acid and Oleanolic Acid Derivatives

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Curcumin induced HepG2 cell apoptosis-associated mitochondrial membrane potential and intracellular free Ca2+ concentration

(2010) Mu Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection

(2010) Yun W. Alelyunas et al.   JOURNAL OF CHROMATOGRAPHY A

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

High-speed solubility screening assay using ultra-performance liquid chromatography/mass spectrometry in drug discovery

(2008) Taro Yamashita et al.   JOURNAL OF CHROMATOGRAPHY A