Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors

GPCR Inhibition in Treating Lymphoma

(2022) Marilia Barreca et al.   ACS Medicinal Chemistry Letters

Synthesis of 2H-Imidazo[2′,1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations

(2022) Vincenzo Cilibrasi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel insights on [1,2]oxazolo[5,4‐ e ]isoindoles on multidrug resistant acute myeloid leukemia cell line

(2022) Manuela Labbozzetta et al.   DRUG DEVELOPMENT RESEARCH

Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells

(2022) Marilia Barreca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

(2022) Katia Grillone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New tricyclic systems as photosensitizers towards triple negative breast cancer cells

(2022) Marilia Barreca et al.   ARCHIVES OF PHARMACAL RESEARCH

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

(2022) Marilia Barreca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of 1,2,3-triazole-phthalimide derivatives as potential drugs against COVID-19: a virtual screening, docking and molecular dynamic study

(2021) Vanderlan Nogueira Holanda et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets

(2021) Isabella Romeo et al.   MOLECULES

Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein

(2021) Virginia Spanò et al.   MOLECULES

Discovery of a Novel Respiratory Syncytial Virus Replication Inhibitor

(2021) Li Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2

(2021) Israa A. Seliem et al.   BIOORGANIC CHEMISTRY

New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS‐CoV‐2

(2021) Israa A. Seliem et al.   ChemMedChem

1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors

(2021) Maria Chiara Pismataro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

(2020) Serena Massari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Viral Emerging Diseases: Challenges in Developing Vaccination Strategies

(2020) Maria Trovato et al.   Frontiers in Immunology

[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation

(2019) Yi-hong Wan et al.   ACTA PHARMACOLOGICA SINICA

Design, synthesis, and structure-activity relationships of novel imidazo[4,5-c]pyridine derivatives as potent non-nucleoside inhibitors of hepatitis C virus NS5B

(2018) Moyi Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

(2018) Ye Tian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrimidine-chloroquinoline hybrids: Synthesis and antiplasmodial activity

(2018) Rakesh Chopra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation

(2018) Hanane Kaoukabi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents

(2018) Konstantina Karypidou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library

(2018) Gaochan Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

(2017) Serena Massari et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

(2016) Shuofeng Yuan et al.   ANTIVIRAL RESEARCH

Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates

(2016) Hassan M. Faidallah et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies

(2015) Deniz Sarigol et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif

(2015) Wenxin Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A deep phylogeny of viral and cellular right-hand polymerases

(2015) Jiří Černý et al.   INFECTION GENETICS AND EVOLUTION

Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles

(2015) Pelin Çıkla-Süzgün et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

(2015) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triazolopyridopyrimidines: an emerging family of effective DNA photocleavers. DNA binding. Antileishmanial activity

(2015) Rosa Adam et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Potential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study

(2015) Michael Berry et al.   Viruses-Basel

1,2,3-Triazole derivatives as antitubercular agents: synthesis, biological evaluation and molecular docking study

(2015) Mubarak H. Shaikh et al.   MedChemComm

Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives

(2014) P. Nagender et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization

(2014) Zhaoqiang Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Small-Molecule Inhibitors of Influenza Virus Polymerase: From Thiophene-3-Carboxamide to Polyamido Scaffolds

(2014) Susan Lepri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Cytotoxicity, and Pro-Apoptosis Activity of Etodolac Hydrazide Derivatives as Anticancer Agents

(2013) Pelin Çıkla et al.   ARCHIV DER PHARMAZIE

Tetrazole and triazole as bioisosteres of carboxylic acid: Discovery of diketo tetrazoles and diketo triazoles as anti-HCV agents

(2013) Wu-Hui Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

(2013) Mark Turlington et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents

(2013) Sangaraiah Nagarajan et al.   CHINESE CHEMICAL LETTERS

Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

(2013) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replicative DNA Polymerases

(2013) E. Johansson et al.   Cold Spring Harbor Perspectives in Biology

Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase

(2012) Adeyemi O. Adedeji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and anti-influenza activity of aminoalkyl rupestonates

(2012) Jiangyu Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

(2012) Jon Jacobs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

(2012) G. Muratore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors

(2011) Antonio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The influenza virus RNA synthesis machine

(2011) Patricia Resa-Infante et al.   RNA Biology

Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naive Subjects

(2010) G. Moyle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938

(2010) P. Ganapati Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors

(2010) S.L. Deev et al.   BIOORGANIC CHEMISTRY

Recent Advances and Future Perspectives of Triazole Analogs as Promising Antiviral Agents

(2010) Rajeev Kharb et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Identification of influenza A nucleoprotein as an antiviral target

(2010) Richard Y Kao et al.   NATURE BIOTECHNOLOGY

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

(2009) S. T. Shi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

(2009) Hui Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Basis of the Interaction for an Essential Subunit PA−PB1 in Influenza Virus RNA Polymerase: Insights from Molecular Dynamics Simulation and Free Energy Calculation

(2009) Huanxiang Liu et al.   MOLECULAR PHARMACEUTICS