Design, Synthesis, and Biological Evaluation of Two Series of Novel A-Ring Fused Steroidal Pyrazines as Potential Anticancer Agents

TiCl4 catalyzed cleavage of (25R)-22-oxo-23-spiroketals. Synthesis of sapogenins with furostanol and pyranone E rings on the side chain

(2019) Alejandro Corona-Díaz et al.   STEROIDS

Stereocontrolled synthesis of the four possible 3-methoxy and 3-benzyloxy-16-triazolyl-methyl-estra-17-ol hybrids and their antiproliferative activities

(2019) Anita Kiss et al.   STEROIDS

Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines

(2019) M. Monier et al.   STEROIDS

Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells

(2018) Muqtadir Baig Mirza et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synthesis and Evaluation of Manganese(II)-Based Ethylenediaminetetraacetic Acid–Ethoxybenzyl Conjugate as a Highly Stable Hepatobiliary Magnetic Resonance Imaging Contrast Agent

(2018) Md. Kamrul Islam et al.   BIOCONJUGATE CHEMISTRY

Synthesis and In Vitro Antitumor Activity of Novel Bivalent β-Carboline-3-carboxylic Acid Derivatives with DNA as a Potential Target

(2018) Hongling Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, cytotoxic evaluation, and molecular docking studies of the semi-synthetic “triterpenoid-steroid” hybrids

(2018) Irina A. Tolmacheva et al.   STEROIDS

Design, synthesis and antitumor activity of steroidal pyridine derivatives based on molecular docking

(2018) Ya-Ling Song et al.   STEROIDS

Facile and efficient access to Androsten-17-(1′,3′,4′)-pyrazoles and Androst-17β-(1′,3′,4′)-pyrazoles via Vilsmeier reagents, and their antiproliferative activity evaluation in vitro

(2017) Jian Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2

(2017) Kejing Lao et al.   STEROIDS

Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro

(2017) Ádám Baji et al.   STEROIDS

Novel 3,4- seco bile acid diamides as selective anticancer proliferation and migration agents

(2016) Shi-Wei Mao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and cytotoxic activity of a novel series of steroidal phenylpyrazoles

(2016) Jian Li et al.   STEROIDS

Microwave-assisted one-pot synthesis of steroid–quinoline hybrids and an evaluation of their antiproliferative activities on gynecological cancer cell lines

(2016) Ádám Baji et al.   RSC Advances

Synthesis and anticancer cell potential of steroidal 16,17-seco-16,17a-dinitriles: Identification of a selective inhibitor of hormone-independent breast cancer cells

(2015) Andrea R. Nikolić et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

(2015) Bernard Barlaam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of pharbinilic acid and derivatives as NF-κB pathway inhibitors

(2015) J. R. Annand et al.   CHEMICAL COMMUNICATIONS

The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20

(2015) George R. Pettit et al.   JOURNAL OF NATURAL PRODUCTS

Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases

(2015) Qi-Wei Jiang et al.   MEDICINAL RESEARCH REVIEWS

Tryptophan Hydroxylase 1 (Tph-1)-Targeted Bone Anabolic Agents for Osteoporosis

(2014) Hai-Jian Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents

(2014) Bin Yu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Synthesis of E- and Z-isomeric progesterone 3-O-methyloximes

(2014) V. A. Zolottsev et al.   RUSSIAN CHEMICAL BULLETIN

Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells

(2014) Fernando Alonso et al.   STEROIDS

Heterocyclic ring extension of androstenedione: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives

(2014) Rafat M. Mohareb et al.   STEROIDS

Heterocyclic ring extension of estrone: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives

(2014) Rafat M. Mohareb et al.   STEROIDS

Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment

(2013) Yu-jiao Song et al.   CANCER LETTERS

A novel [1,2,4] triazolo [1,5-a] pyrimidine-based phenyl-linked steroid dimer: Synthesis and its cytotoxic activity

(2013) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: Synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines

(2013) Rafat M. Mohareb et al.   STEROIDS

Synthesis and structure–activity relationships study of cytotoxic bufalin 3-nitrogen-containing-ester derivatives

(2013) Biao Ma et al.   STEROIDS

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

(2012) Jorge A. R. Salvador et al.   NATURAL PRODUCT REPORTS

Anticancer steroids: linking natural and semi-synthetic compounds

(2012) Jorge A. R. Salvador et al.   NATURAL PRODUCT REPORTS

Reaction of pregnenolone with cyanoacetylhydrazine: Novel synthesis of hydrazide–hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations

(2012) Rafat M. Mohareb et al.   STEROIDS

Heterocyclizations of pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations

(2012) Rafat M. Mohareb et al.   STEROIDS

Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics

(2012) Mustapha Haddach et al.   ACS Medicinal Chemistry Letters

D-ring substituted 1,2,3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation

(2010) Abid H. Banday et al.   STEROIDS

Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents

(2010) Abid H. Banday et al.   STEROIDS