ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation

Generation of a new Adar1p150-/- mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis

(2023) Zhen Liang et al.   RNA

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

(2022) Ting Zhang et al.   NATURE

ADAR1 mutation causes ZBP1-dependent immunopathology

(2022) Nicholas W. Hubbard et al.   NATURE

ADAR1 averts fatal type I interferon induction by ZBP1

(2022) Huipeng Jiao et al.   NATURE

RNA editing underlies genetic risk of common inflammatory diseases

(2022) Qin Li et al.   NATURE

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

(2022) Richard de Reuver et al.   NATURE

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

(2021) Jaclyn Quin et al.   TRENDS IN BIOCHEMICAL SCIENCES

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

(2021) Jung In Kim et al.   PLoS Genetics

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

(2021) Megan Maurano et al.   IMMUNITY

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

(2021) Taisuke Nakahama et al.   IMMUNITY

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses

(2021) Qiannan Tang et al.   IMMUNITY

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

(2021) Richard de Reuver et al.   Cell Reports

Cellular origins of dsRNA, their recognition and consequences

(2021) Y. Grace Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

To protect and modify double-stranded RNA – the critical roles of ADARs in development, immunity and oncogenesis

(2020) Emily A. Erdmann et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Editor’s I on Disease Development

(2019) Mamta Jain et al.   TRENDS IN GENETICS

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

An origin of the immunogenicity of in vitro transcribed RNA

(2018) Xin Mu et al.   NUCLEIC ACIDS RESEARCH

PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

(2018) Yoosik Kim et al.   MOLECULAR CELL

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

(2018) Jeffrey J. Ishizuka et al.   NATURE

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

(2018) Michael S. Haney et al.   NATURE GENETICS

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

(2018) Hugh S. Gannon et al.   Nature Communications

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150

(2018) Christian K. Pfaller et al.   PLOS BIOLOGY

Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease

(2017) Gillian Rice et al.   NEUROPEDIATRICS

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

(2017) David W. Morgens et al.   Nature Communications

Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses

(2016) Cyril X. George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes

(2016) David W Morgens et al.   NATURE BIOTECHNOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Aicardi-Goutières Syndrome Is Caused by IFIH1 Mutations

(2014) Hirotsugu Oda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator

(2014) Y. Kim et al.   GENES & DEVELOPMENT

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown

(2013) R. A. Elbarbary et al.   GENES & DEVELOPMENT

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

(2011) Charles E. Samuel   VIROLOGY

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

(2009) Ann M. Toth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine Deaminase ADAR1 Increases Gene Expression at the Translational Level by Decreasing Protein Kinase PKR-Dependent eIF-2α Phosphorylation

(2009) Ying Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

ADAR1 Interacts with PKR during Human Immunodeficiency Virus Infection of Lymphocytes and Contributes to Viral Replication

(2009) G. Clerzius et al.   JOURNAL OF VIROLOGY

RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment

(2009) Zhiqun Li et al.   VIROLOGY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY