Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation

(2023) Brajesh K. Rai et al.   Scientific Reports

Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

(2023) Romain Ollier et al.   mAbs

In silico prediction of post-translational modifications in therapeutic antibodies

(2022) Shabdita Vatsa   mAbs

Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics

(2022) Pin-Kuang Lai et al.   mAbs

Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies

(2022) Rahmad Akbar et al.   mAbs

Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties

(2022) Shihao Hu et al.   mAbs

Application of a Simple Short-Range Attraction and Long-Range Repulsion Colloidal Model toward Predicting the Viscosity of Protein Solutions

(2022) Sabitoj Singh Virk et al.   MOLECULAR PHARMACEUTICS

Automated Mass Spectrometry Multi-Attribute Method Analyses for Process Development and Characterization of mAbs

(2021) Yvonne Ehwang Song et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies

(2021) Pin-Kuang Lai et al.   MOLECULAR PHARMACEUTICS

Denaturing and Native Mass Spectrometric Analytics for Biotherapeutic Drug Discovery Research: Historical, Current, and Future Personal Perspectives

(2021) Iain D. G. Campuzano et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Nano differential scanning fluorimetry for comparability studies of therapeutic proteins

(2020) Jie Wen et al.   ANALYTICAL BIOCHEMISTRY

A single molecular descriptor to predict solution behavior of therapeutic antibodies

(2020) Jonathan S. Kingsbury et al.   Science Advances

Resolving Liquid-Liquid Phase Separation for a Peptide Fused Monoclonal Antibody by Formulation Optimization

(2020) Wei Qi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions

(2020) Yue Sun et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

(2019) Iain D. G. Campuzano et al.   ANALYTICAL CHEMISTRY

Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis

(2019) Thomas E. Kraft et al.   mAbs

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

(2018) Lindsay B. Avery et al.   mAbs

Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab

(2018) Neungseon Seo et al.   mAbs

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

(2018) Alison Betts et al.   mAbs

AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches

(2018) Kannan Sankar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Electrostatically Mediated Protein-Protein Interactions for Monoclonal Antibodies: A Combined Experimental and Coarse-Grained Molecular Modeling Approach

(2018) Glenn M. Ferreira et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Deamidation and isomerization liability analysis of 131 clinical-stage antibodies

(2018) Xiaojun Lu et al.   mAbs

In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions

(2017) Dheeraj S. Tomar et al.   mAbs

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent applications of light scattering measurement in the biological and biopharmaceutical sciences

(2016) Allen P. Minton   ANALYTICAL BIOCHEMISTRY

Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability

(2016) Frederick W. Jacobsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

(2016) Michael Dillon et al.   mAbs

A comparison of biophysical characterization techniques in predicting monoclonal antibody stability

(2016) Geetha Thiagarajan et al.   mAbs

Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

(2016) James C. Geoghegan et al.   mAbs

Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development

(2016) Dheeraj S. Tomar et al.   mAbs

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

(2015) Daniela Bumbaca Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

(2015) Ryan L Kelly et al.   mAbs

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

(2015) Amita Datta-Mannan et al.   mAbs

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

(2015) Amita Datta-Mannan et al.   mAbs

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

(2015) Angela Schoch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Monoclonal Antibody Selection and Engineering using Measurements of Colloidal Protein Interactions

(2014) Steven B. Geng et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications

(2014) Mark Haverick et al.   mAbs

Prediction of colloidal stability of high concentration protein formulations

(2014) Patrick Garidel et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties

(2014) Li Li et al.   PHARMACEUTICAL RESEARCH

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

(2014) Jasmin F. Sydow et al.   PLoS One

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling Formulated Monoclonal Antibodies by 1H NMR Spectroscopy

(2013) Leszek Poppe et al.   ANALYTICAL CHEMISTRY

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

(2013) Tilman Schlothauer et al.   mAbs

High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

(2013) Yuqi Liu et al.   mAbs

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

A strategy for risk mitigation of antibodies with fast clearance

(2012) Isidro Hötzel et al.   mAbs

Implementation of a universal analytical method in early-stage development of human antibody therapeutics: application to pharmacokinetic assessment for candidate selection

(2012) Judy Y Shih et al.   Bioanalysis

High‐Throughput Assessment of Thermal and Colloidal Stability Parameters for Monoclonal Antibody Formulations

(2011) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Viscosity Behavior of High-Concentration Monoclonal Antibody Solutions: Correlation with Interaction Parameter and Electroviscous Effects

(2011) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Recent advances of capillary electrophoresis in pharmaceutical analysis

(2010) Leena Suntornsuk   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions

(2009) Feng He et al.   ANALYTICAL BIOCHEMISTRY

Large-Scale Identification and Quantification of Covalent Modifications in Therapeutic Proteins

(2009) Zhongqi Zhang   ANALYTICAL CHEMISTRY

A rapid, sensitive and economical assessment of monoclonal antibody conformational stability by intrinsic tryptophan fluorescence spectroscopy

(2008) Patrick Garidel et al.   Biotechnology Journal

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

(2008) Thomas M. Dillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY