In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

Entanglement Model of Antibody Viscosity

(2014) Jeremy D. Schmit et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties

(2014) Li Li et al.   PHARMACEUTICAL RESEARCH

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

(2014) Jasmin F. Sydow et al.   PLoS One

Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

(2013) Ekaterine Kortkhonjia et al.   mAbs

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Isomerization of Asp–Asp Motif in Model Peptides and a Monoclonal Antibody Fab Fragment

(2012) Li Yi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

A strategy for risk mitigation of antibodies with fast clearance

(2012) Isidro Hötzel et al.   mAbs

Accurate Determination of Succinimide Degradation Products Using High Fidelity Trypsin Digestion Peptide Map Analysis

(2011) X. Christopher Yu et al.   ANALYTICAL CHEMISTRY

Something new under the skin

(2011) Michael Eisenstein   NATURE BIOTECHNOLOGY

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

(2011) Sandeep Yadav et al.   PHARMACEUTICAL RESEARCH

Hydrophobic salts markedly diminish viscosity of concentrated protein solutions

(2010) Wei Du et al.   BIOTECHNOLOGY AND BIOENGINEERING

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Specific interactions in high concentration antibody solutions resulting in high viscosity

(2009) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

(2008) Sonoko Kanai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES