In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions

Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

(2016) James C. Geoghegan et al.   mAbs

Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development

(2016) Dheeraj S. Tomar et al.   mAbs

Critical Examination of the Colloidal Particle Model of Globular Proteins

(2015) Prasad S. Sarangapani et al.   BIOPHYSICAL JOURNAL

Computational tool for the early screening of monoclonal antibodies for their viscosities

(2015) Neeraj J Agrawal et al.   mAbs

Antibodies to watch in 2016

(2015) Janice M. Reichert   mAbs

Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobicversuselectrostatic inter-molecular interactions

(2015) Pilarin Nichols et al.   mAbs

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein aggregation and its impact on product quality

(2014) Christopher J Roberts   CURRENT OPINION IN BIOTECHNOLOGY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Highly Viscous Antibody Solutions Are a Consequence of Network Formation Caused by Domain–Domain Electrostatic Complementarities: Insights from Coarse-Grained Simulations

(2014) Patrick M. Buck et al.   MOLECULAR PHARMACEUTICS

Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties

(2014) Li Li et al.   PHARMACEUTICAL RESEARCH

Assessment of Physical Stability of an Antibody Drug Conjugate by Higher Order Structure Analysis: Impact of Thiol- Maleimide Chemistry

(2014) Jianxin Guo et al.   PHARMACEUTICAL RESEARCH

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Which are the antibodies to watch in 2013?

(2013) Janice M. Reichert   mAbs

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH

Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

(2013) Xiaoling Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Disulfide Scrambling in IgG2 Monoclonal Antibodies: Insights from Molecular Dynamics Simulations

(2011) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

Calibrative approaches to protein solubility modeling of a mutant series using physicochemical descriptors

(2010) William F. Long et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies

(2010) Frank R. Brennan et al.   mAbs

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS