High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

A systematic multitechnique approach for detection and characterization of reversible self-association during formulation development of therapeutic antibodies

(2013) Reza Esfandiary et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Developability studies before initiation of process development

(2013) Xiaoyu Yang et al.   mAbs

High throughput detection of antibody self-interaction by bio-layer interferometry

(2013) Tingwan Sun et al.   mAbs

Rapid Analysis of Antibody Self-Association in Complex Mixtures Using Immunogold Conjugates

(2013) Shantanu V. Sule et al.   MOLECULAR PHARMACEUTICS

Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool

(2013) Y. Xu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Aggregation and pH–Temperature Phase Behavior for Aggregates of an IgG2 Antibody

(2012) Erinc Sahin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A strategy for risk mitigation of antibodies with fast clearance

(2012) Isidro Hötzel et al.   mAbs

Solubility evaluation of murine hybridoma antibodies

(2012) Stacey Spencer et al.   mAbs

General strategy for the generation of human antibody variable domains with increased aggregation resistance

(2012) K. Dudgeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of self-association of a human monoclonal antibody CNTO607

(2012) Deidra Bethea et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

(2012) J. M. Perchiacca et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineering Aggregation-Resistant Antibodies

(2012) Joseph M. Perchiacca et al.   Annual Review of Chemical and Biomolecular Engineering

High-Throughput Analysis of Concentration-Dependent Antibody Self-Association

(2011) Shantanu V. Sule et al.   BIOPHYSICAL JOURNAL

Predicting solution aggregation rates for therapeutic proteins: Approaches and challenges

(2011) Christopher J. Roberts et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Therapeutic antibodies: Market considerations, disease targets and bioprocessing

(2011) John G. Elvin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition

(2011) Hirotaka Nishi et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

High‐Throughput Assessment of Thermal and Colloidal Stability Parameters for Monoclonal Antibody Formulations

(2011) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Role of electrostatic interactions during protein ultrafiltration

(2010) Mahsa M. Rohani et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

(2010) Atul Saluja et al.   BIOPHYSICAL JOURNAL

A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein–protein interactions in protein formulation development: A case study of a therapeutic monoclonal antibody

(2010) Virginie Le Brun et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Comparative Effects of pH and Ionic Strength on Protein–Protein Interactions, Unfolding, and Aggregation for IgG1 Antibodies

(2010) Erinc Sahin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

(2010) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

Structure-based engineering of a monoclonal antibody for improved solubility

(2010) S.-J. Wu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Biospecific protein immobilization for rapid analysis of weak protein interactions using self-interaction nanoparticle spectroscopy

(2009) Aditya N. Bengali et al.   BIOTECHNOLOGY AND BIOENGINEERING

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

(2009) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

High throughput thermostability screening of monoclonal antibody formulations

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation

(2009) Branden A. Salinas et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Specific interactions in high concentration antibody solutions resulting in high viscosity

(2009) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

(2009) Steven A. Jacobs et al.   PHARMACEUTICAL RESEARCH

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

(2008) Sonoko Kanai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Developability assessment in pharmaceutical industry: An integrated group approach for selecting developable candidates

(2008) Vishal Saxena et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Self-Interaction Nanoparticle Spectroscopy:  A Nanoparticle-Based Protein Interaction Assay

(2008) Peter M. Tessier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-Throughput Self-Interaction Chromatography: Applications in Protein Formulation Prediction

(2008) David H. Johnson et al.   PHARMACEUTICAL RESEARCH