AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When Good Goes Awry: The Aggregation of Protein Therapeutics

(2017) Vladimir Uversky et al.   PROTEIN AND PEPTIDE LETTERS

Ensemble Modeling and Intracellular Aggregation of an Engineered Immunoglobulin-Like Domain

(2016) Kyle Trainor et al.   JOURNAL OF MOLECULAR BIOLOGY

WALTZ-DB: a benchmark database of amyloidogenic hexapeptides

(2015) J. Beerten et al.   BIOINFORMATICS

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies

(2015) Patricia Estep et al.   mAbs

A novel screening method to assess developability of antibody-like molecules

(2015) Neeraj Kohli et al.   mAbs

AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures

(2015) Rafael Zambrano et al.   NUCLEIC ACIDS RESEARCH

Prediction of Peptide and Protein Propensity for Amyloid Formation

(2015) Carlos Família et al.   PLoS One

PASTA 2.0: an improved server for protein aggregation prediction

(2014) Ian Walsh et al.   NUCLEIC ACIDS RESEARCH

Antibody structure determination using a combination of homology modeling, energy-based refinement, and loop prediction

(2014) Kai Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Electrostatic Effects in Filamentous Protein Aggregation

(2013) Alexander K. Buell et al.   BIOPHYSICAL JOURNAL

Ab initiostructure prediction of the antibody hypervariable H3 loop

(2013) Kai Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Soluble expression of proteins correlates with a lack of positively-charged surface

(2013) Pedro Chan et al.   Scientific Reports

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Progress in super long loop prediction

(2011) Suwen Zhao et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Exposure of Hydrophobic Surfaces Initiates Aggregation of Diverse ALS-Causing Superoxide Dismutase-1 Mutants

(2010) Christian Münch et al.   JOURNAL OF MOLECULAR BIOLOGY

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Adnectins: engineered target-binding protein therapeutics

(2010) D. Lipovsek   PROTEIN ENGINEERING DESIGN & SELECTION

Mechanisms of Protein Aggregation

(2009) John Philo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

(2009) Steven A. Jacobs et al.   PHARMACEUTICAL RESEARCH

The Zyggregator method for predicting protein aggregation propensities

(2008) Gian Gaetano Tartaglia et al.   CHEMICAL SOCIETY REVIEWS