SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease

SIRT2 as a potential new therapeutic target for Alzheimer's disease

(2023) Noemi Sola-Sevilla et al.   Neural Regeneration Research

Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD

(2022) Julen Goikolea et al.   Alzheimers Research & Therapy

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

(2022) Shweta S. Puntambekar et al.   Molecular Neurodegeneration

Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice

(2022) Ning Bai et al.   Cell Reports

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

(2022) Neeraj Singh et al.   Science Advances

The Sirtuin 2 Inhibitor AK-7 Leads to an Antidepressant-Like Effect in Mice via Upregulation of CREB1, BDNF, and NTRK2 Pathways

(2022) Ebru Guclu et al.   MOLECULAR NEUROBIOLOGY

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

(2022) Amaya Azqueta et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Understanding the Potential Role of Sirtuin 2 on Aging: Consequences of SIRT2.3 Overexpression in Senescence

(2021) Noemi Sola-Sevilla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders

(2021) Xiuqi Chen et al.   Frontiers in Neuroscience

Neuroinflammation and Alzheimer’s Disease: A Machine Learning Approach to CSF Proteomics

(2021) Lorenzo Gaetani et al.   Cells

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Correlation Between SIRT2 3'UTR Gene Polymorphism and the Susceptibility to Alzheimer’s Disease

(2020) Yuanyuan Shen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Microglial Corpse Clearance: Lessons From Macrophages

(2020) Mar Márquez-Ropero et al.   Frontiers in Immunology

RTN4B‐mediated suppression of Sirtuin 2 activity ameliorates β‐amyloid pathology and cognitive impairment in Alzheimer's disease mouse model

(2020) Yan Wang et al.   AGING CELL

The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?

(2020) Lin Zhang et al.   Frontiers in Oncology

Prolactin enhances hippocampal synaptic plasticity in female mice of reproductive age

(2020) Alfonsa Zamora‐Moratalla et al.   HIPPOCAMPUS

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

(2019) Hanzhi Luo et al.   Cell Reports

Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model

(2019) Teresa Diaz-Perdigon et al.   NEUROPSYCHOPHARMACOLOGY

SIRT2: Controversy and multiple roles in disease and physiology

(2019) Yan Wang et al.   AGEING RESEARCH REVIEWS

Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation

(2019) Ziyi Wu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1

(2019) Fangzhou Jiao et al.   Journal of Neuroimmune Pharmacology

N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice

(2019) Min Hee Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

(2019) Anna Rosenberg et al.   Alzheimers Research & Therapy

Intermittent hypoxia improves cognition and reduces anxiety‐related behavior in APP/PS1 mice

(2019) Sheng‐Xi Meng et al.   Brain and Behavior

Alzheimer’s disease paper 1: clinical update on epidemiology, pathophysiology and diagnosis

(2018) Dhamidhu Eratne et al.   Australasian Psychiatry

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology

(2018) A.R. Esteves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood

(2018) Prapimpun Wongchitrat et al.   Current Alzheimer Research

MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson’s Disease

(2018) Sifan Sun et al.   Frontiers in Molecular Neuroscience

Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B

(2017) Yong Zhang et al.   INFLAMMATION

SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action

(2017) Mercedes Erburu et al.   NEUROPHARMACOLOGY

Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory

(2017) Guan Wang et al.   Cell Reports

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

(2017) Rita Machado de Oliveira et al.   PLOS BIOLOGY

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

(2017) Eleonora Ciarlo et al.   Frontiers in Immunology

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

(2016) Gloria Biella et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology

(2016) D. F. Silva et al.   MOLECULAR NEUROBIOLOGY

SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice

(2016) Ban Wang et al.   NEUROCHEMICAL RESEARCH

Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System

(2016) T. Jayasena et al.   Scientific Reports

Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment

(2016) Louise Ørum Olesen et al.   PLoS One

SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation

(2015) Fang Yuan et al.   JOURNAL OF NEUROCHEMISTRY

SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia

(2015) Heyu Chen et al.   NEUROREPORT

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

(2014) Ae Sin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

(2014) B. J. North et al.   EMBO JOURNAL

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

(2014) Prithviraj Bose et al.   PHARMACOLOGY & THERAPEUTICS

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

(2014) Giuseppe Lo Sasso et al.   PLoS One

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

Constitutive Nuclear Localization of an Alternatively Spliced Sirtuin-2 Isoform

(2013) Johannes G.M. Rack et al.   JOURNAL OF MOLECULAR BIOLOGY

Histone-deacetylase inhibitors produce positive results in the GADD45a-GFP GreenScreen HC assay

(2013) Donna Johnson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors

(2012) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

(2012) Vanita Chopra et al.   Cell Reports

Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

(2012) Tara L. Spires-Jones et al.   Frontiers in Pharmacology

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice

(2009) P. Yan et al.   JOURNAL OF NEUROSCIENCE