CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

(2021) Emma Gerrits et al.   ACTA NEUROPATHOLOGICA

Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

(2021) Jielin Xu et al.   GENOME RESEARCH

Possible Mechanisms of Tau Spread and Toxicity in Alzheimer’s Disease

(2021) Huiqin Zhang et al.   Frontiers in Cell and Developmental Biology

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

(2020) Zhentao Zhang et al.   Translational Neurodegeneration

Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients

(2020) Carlos Pomilio et al.   GeroScience

APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease

(2020) Aivi T. Nguyen et al.   ACTA NEUROPATHOLOGICA

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation

(2019) Huadong Ni et al.   Journal of Neuroinflammation

Neuroinflammation and fractalkine signaling in Alzheimer’s disease

(2019) Dylan J. Finneran et al.   Journal of Neuroinflammation

The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology

(2019) Qingyuan Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction

(2019) Qingyuan Fan et al.   JOURNAL OF NEUROSCIENCE

Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease

(2018) Sara Castro-Sánchez et al.   GLIA

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Evidence for a protective role of CX3CL1/CX3CR1 axis in a model of amyotrophic lateral sclerosis

(2018) Chang Liu et al.   BIOLOGICAL CHEMISTRY

Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease

(2018) Lisbell D. Estrada et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Association of the CX3CR1-V249I Variant with Neurofibrillary Pathology Progression in Late-Onset Alzheimer’s Disease

(2017) Alan López-López et al.   MOLECULAR NEUROBIOLOGY

Common polymorphisms of chemokine (C-X3-C motif) receptor 1 gene modify amyotrophic lateral sclerosis outcome: A population-based study

(2017) Andrea Calvo et al.   MUSCLE & NERVE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

(2016) Kanchan Bisht et al.   Jove-Journal of Visualized Experiments

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination

(2015) Shweta S. Puntambekar et al.   GLIA

Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics

(2015) Christian Madry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fractalkine Over Expression Suppresses α-Synuclein-mediated Neurodegeneration

(2015) Kevin R Nash et al.   MOLECULAR THERAPY

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway

(2014) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

CX3CR1 Is a Modifying Gene of Survival and Progression in Amyotrophic Lateral Sclerosis

(2014) Alan Lopez-Lopez et al.   PLoS One

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

(2014) Cristina Limatola et al.   Frontiers in Cellular Neuroscience

Soluble A  Promotes Wild-Type Tau Pathology In Vivo

(2012) M. A. Chabrier et al.   JOURNAL OF NEUROSCIENCE

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain

(2009) Floyd Sarsoza et al.   ACTA NEUROPATHOLOGICA

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY