Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation

The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss

(2019) Yongzhi Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective role of AGK2 on thioacetamide-induced acute liver failure in mice

(2019) Fang-Zhou Jiao et al.   LIFE SCIENCES

Pathological histone acetylation in Parkinson’s disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition

(2018) Ian F. Harrison et al.   NEUROSCIENCE LETTERS

Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

(2018) Ziyi Wu et al.   Frontiers in Cellular Neuroscience

Sirtuins in Neuroendocrine Regulation and Neurological Diseases

(2018) Yuki Fujita et al.   Frontiers in Neuroscience

Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination

(2017) Emmett E. Whitaker et al.   Journal of Anesthesia

Sevoflurane suppresses microglial M2 polarization

(2017) Zengyang Pei et al.   NEUROSCIENCE LETTERS

Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration

(2017) Preeti Singh et al.   Parkinsons Disease

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

(2017) Yanning Li et al.   Frontiers in Pharmacology

Sirtuin 2 Regulates Microvascular Inflammation during Sepsis

(2017) Nancy Buechler et al.   Journal of Immunology Research

Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

(2016) Shabir Ahmad Ganai et al.   Current Neuropharmacology

Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen-activated protein kinase phosphatase-1

(2016) Jie Wang et al.   HEPATOLOGY

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

(2016) Gloria Biella et al.   JOURNAL OF ALZHEIMERS DISEASE

Anesthesia-induced neurotoxicity in an animal model of the developing brain: mechanism and therapies

(2016) Maiko Satomoto   Neural Regeneration Research

SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice

(2016) Ban Wang et al.   NEUROCHEMICAL RESEARCH

Modulating epigenetic HAT activity for reinstating acetylation homeostasis: A promising therapeutic strategy for neurological disorders

(2016) Shabir Ahmad Ganai et al.   PHARMACOLOGY & THERAPEUTICS

Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic

(2015) M.Q. Zhang et al.   BRITISH JOURNAL OF ANAESTHESIA

Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model

(2015) T. Zhao et al.   CURRENT MOLECULAR MEDICINE

SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation

(2015) Fang Yuan et al.   JOURNAL OF NEUROCHEMISTRY

SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia

(2015) Heyu Chen et al.   NEUROREPORT

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

(2015) Yoon-Mi Lee et al.   Biomed Research International

SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression

(2014) Y. J. Jung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epigenetic Regulation of Memory by Acetylation and Methylation of Chromatin: Implications in Neurological Disorders, Aging, and Addiction

(2014) Nilkantha Sen   NEUROMOLECULAR MEDICINE

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

(2014) Giuseppe Lo Sasso et al.   PLoS One

Histone deacetylases in memory and cognition

(2014) J. Penney et al.   Science Signaling

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

(2013) Xia Shen et al.   ANESTHESIOLOGY

Sirt2 suppresses inflammatory responses in collagen-induced arthritis

(2013) Jiangtao Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

(2012) Vanita Chopra et al.   Cell Reports

A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase

(2011) David M. Taylor et al.   ACS Chemical Biology

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology

(2009) Kai Harting et al.   EUROPEAN JOURNAL OF CELL BIOLOGY