The Sirtuin 2 Inhibitor AK-7 Leads to an Antidepressant-Like Effect in Mice via Upregulation of CREB1, BDNF, and NTRK2 Pathways

A New Paradigm for Achieving a Rapid Antidepressant Response

(2020) Gin S. Malhi et al.   DRUGS

NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice

(2020) Dongping Li et al.   Journal of Neuroinflammation

Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus

(2020) Xiangdong Du et al.   Translational Psychiatry

Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2

(2020) Charlotte Trautmann et al.   NEUROPHARMACOLOGY

Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective

(2020) Keng Yoon Yeong et al.   ACS Chemical Neuroscience

Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System

(2020) Pavithra Chandramowlishwaran et al.   Frontiers in Neuroscience

SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice

(2019) Chun-Mei Duan et al.   BEHAVIOURAL BRAIN RESEARCH

Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases

(2019) Yuqing Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model - are we there yet?

(2018) Emmanuel Jesulola et al.   BEHAVIOURAL BRAIN RESEARCH

Role and Possible Mechanisms of Sirt1 in Depression

(2018) Guofang Lu et al.   Oxidative Medicine and Cellular Longevity

Histone deacetylases (HDACs) as therapeutic target for depressive disorders

(2018) Paulina Misztak et al.   Pharmacological Reports

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

(2018) Marion J. F. Levy et al.   PSYCHOPHARMACOLOGY

SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action

(2017) Mercedes Erburu et al.   NEUROPHARMACOLOGY

From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder

(2017) Bangshan Liu et al.   Frontiers in Cellular Neuroscience

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

(2016) Gloria Biella et al.   JOURNAL OF ALZHEIMERS DISEASE

SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens

(2016) H.-D. Kim et al.   JOURNAL OF NEUROSCIENCE

Behavioural effects of basal ganglia rho-kinase inhibition in the unilateral 6-hydroxydopamine rat model of Parkinson’s disease

(2016) Salim Yalcin Inan et al.   METABOLIC BRAIN DISEASE

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

(2015) M. Erburu et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation

(2015) Fang Yuan et al.   JOURNAL OF NEUROCHEMISTRY

The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

(2015) Xiqun Chen et al.   PLoS One

Sirtuin Activity in Dentate Gyrus Contributes to Chronic Stress-Induced Behavior and Extracellular Signal-Regulated Protein Kinases 1 and 2 Cascade Changes in the Hippocampus

(2013) Chantelle L. Ferland et al.   BIOLOGICAL PSYCHIATRY

The Novel Caspase-3 Substrate Gap43 is Involved in AMPA Receptor Endocytosis and Long-Term Depression

(2013) Meng-Hsuan Han et al.   MOLECULAR & CELLULAR PROTEOMICS

Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)

(2013) M L Molendijk et al.   MOLECULAR PSYCHIATRY

Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors

(2012) E. Venzala et al.   PSYCHOPHARMACOLOGY

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

(2012) Vanita Chopra et al.   Cell Reports

Is serotonergic function associated with the antidepressant effects of modified-electroconvulsive therapy?

(2011) Shinjiro Goto et al.   JOURNAL OF AFFECTIVE DISORDERS

The role of BDNF in depression on the basis of its location in the neural circuitry

(2010) Hui Yu et al.   ACTA PHARMACOLOGICA SINICA

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE