Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitors
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Title
Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitors
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 66, Issue 14, Pages 9325-9344
Publisher
American Chemical Society (ACS)
Online
2023-07-14
DOI
10.1021/acs.jmedchem.3c00712
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Note: Only part of the references are listed.- Advances and challenges in therapeutic targeting of NRF2
- (2023) Albena T. Dinkova-Kostova et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review
- (2023) Joe M. McCord et al. Antioxidants
- Peptide‐Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization
- (2023) Xing-Yu Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor
- (2023) Kazuki Otake et al. ACS Medicinal Chemistry Letters
- Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction
- (2022) Fabio Begnini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates
- (2022) Lingzhi Qu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode
- (2022) Nikolaos Georgakopoulos et al. JOURNAL OF MEDICINAL CHEMISTRY
- The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity
- (2022) Laura Casares et al. Redox Biology
- Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N′-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction
- (2022) Sumi Lee et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical evidence
- (2022) Mina Alimohammadi et al. INFLAMMATION RESEARCH
- An Overview of NRF2-Activating Compounds Bearing α,β-Unsaturated Moiety and Their Antioxidant Effects
- (2022) Melford Chuka Egbujor et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Crystallography-Guided Optimizations of the Keap1–Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides
- (2022) Guodong Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo
- (2022) Ayumi Kuga et al. MOLECULAR AND CELLULAR BIOLOGY
- GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders
- (2022) Divya Soni et al. Pharmacological Reports
- Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives
- (2022) Xin-xing Yang et al. Frontiers in Pharmacology
- Normal and Pathological NRF2 Signalling in the Central Nervous System
- (2022) Tony Heurtaux et al. Antioxidants
- Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1
- (2022) Rita Moreno et al. FREE RADICAL BIOLOGY AND MEDICINE
- The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance
- (2022) Rohini Srivastava et al. FREE RADICAL BIOLOGY AND MEDICINE
- Design, synthesis and evaluation of novel small molecules acting as Keap1-Nrf2 protein-protein interaction inhibitors
- (2022) Yunfeng Sun et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
- (2022) Enrique Crisman et al. MEDICINAL RESEARCH REVIEWS
- An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver
- (2022) Raquel Fernández-Ginés et al. Redox Biology
- The KEAP1-NRF2 System and Esophageal Cancer
- (2022) Wataru Hirose et al. Cancers
- Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease
- (2022) Manuj Ahuja et al. Antioxidants
- Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds
- (2022) Serena Silvestro et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery
- (2022) Dilip Narayanan et al. Journal of Medicinal Chemistry
- Structural basis of transcription regulation by CNC family transcription factor, Nrf2
- (2022) Toru Sengoku et al. NUCLEIC ACIDS RESEARCH
- Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds
- (2021) Jakob S. Pallesen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
- (2021) Yuta Horie et al. Communications Biology
- Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation
- (2021) Dhulfiqar Ali Abed et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts
- (2021) Yue-huan Zheng et al. Cell Death & Disease
- iKeap1 activates Nrf2 signaling to protect myocardial cells from oxygen glucose deprivation/re-oxygenation-induced oxidative injury
- (2021) Yicheng Jiang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury
- (2021) Le Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction
- (2021) David Norton et al. JOURNAL OF MEDICINAL CHEMISTRY
- The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
- (2021) Sharadha Dayalan Naidu et al. iScience
- Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction
- (2020) Dhulfiqar Ali Abed et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present)
- (2020) Haishan Zhou et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors
- (2020) Phillip R. Lazzara et al. ACS Medicinal Chemistry Letters
- Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Protein–Protein Interaction
- (2020) Yong Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
- (2020) Sumi Lee et al. MEDICINAL CHEMISTRY RESEARCH
- An open-source drug discovery platform enables ultra-large virtual screens
- (2020) Christoph Gorgulla et al. NATURE
- Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction
- (2020) Jesus M. Ontoria et al. ACS Medicinal Chemistry Letters
- Oxidative Stress in Cancer
- (2020) John D. Hayes et al. CANCER CELL
- CDDO-Imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1
- (2020) Xiaoli Meng et al. JOURNAL OF MEDICINAL CHEMISTRY
- A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions
- (2020) Mengchen Lu et al. Redox Biology
- Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease
- (2020) Yi Sun et al. BIOORGANIC CHEMISTRY
- Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors
- (2020) Yi Mou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Structure–Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors
- (2020) Hai-Shan Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oxidative Stress in Cardiovascular Diseases
- (2020) Emilie Dubois-Deruy et al. Antioxidants
- Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions
- (2020) Meng-Chen Lu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Mining Natural Products for Macrocycles to Drug Difficult Targets
- (2020) Fabio Begnini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
- (2019) Antonio Cuadrado et al. NATURE REVIEWS DRUG DISCOVERY
- Structure-Based Macrocycle Design in Small-Molecule Drug Discovery and Simple Metrics To Identify Opportunities for Macrocyclization of Small-Molecule Ligands
- (2019) Maxwell D. Cummings et al. JOURNAL OF MEDICINAL CHEMISTRY
- NRF2 Activation in Cancer: From DNA to Protein
- (2019) Erica W. Cloer et al. CANCER RESEARCH
- Nrf2 in cancers: A double‐edged sword
- (2019) Shijia Wu et al. Cancer Medicine
- A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity
- (2019) Kim T. Tran et al. JOURNAL OF MEDICINAL CHEMISTRY
- ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
- (2019) Anastasiya V. Snezhkina et al. Oxidative Medicine and Cellular Longevity
- Biochemical basis and metabolic interplay of redox regulation
- (2019) Lixiao Zhang et al. Redox Biology
- Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability
- (2019) Phillip R. Lazzara et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators
- (2019) Bin Ma et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- NRF2 and the Hallmarks of Cancer
- (2018) Montserrat Rojo de la Vega et al. CANCER CELL
- Hypoxia, oxidative stress and inflammation
- (2018) Trudy McGarry et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative stress in autoimmune rheumatic diseases
- (2018) Miranda J. Smallwood et al. FREE RADICAL BIOLOGY AND MEDICINE
- Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo
- (2018) Eiki Yoshida et al. GENES TO CELLS
- Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases
- (2018) Jakob S. Pallesen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Canonical and non-canonical mechanisms of Nrf2 activation
- (2018) Carlos Alfredo Silva-Islas et al. PHARMACOLOGICAL RESEARCH
- Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
- (2018) Antonio Cuadrado et al. PHARMACOLOGICAL REVIEWS
- Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
- (2018) Antonio Cuadrado et al. Redox Biology
- Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
- (2018) C. Cheignon et al. Redox Biology
- Antioxidant response elements: Discovery, classes, regulation and potential applications
- (2018) Azhwar Raghunath et al. Redox Biology
- Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors
- (2018) Benjamin G. Richardson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- (2018) Evanna L. Mills et al. NATURE
- Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation
- (2018) Eleni N. Tsakiri et al. AGING CELL
- Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy
- (2018) Zheng-Yu Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species
- (2017) Philip Wenzel et al. FREE RADICAL BIOLOGY AND MEDICINE
- The opposing roles of NO and oxidative stress in cardiovascular disease
- (2017) Rebecca H. Ritchie et al. PHARMACOLOGICAL RESEARCH
- Small molecules inhibiting Keap1–Nrf2 protein–protein interactions: a novel approach to activate Nrf2 function
- (2017) Chunlin Zhuang et al. MedChemComm
- Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease
- (2017) Isabel Gameiro et al. Scientific Reports
- Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate
- (2016) Kathleen M. Mulvaney et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions
- (2016) Zheng-Yu Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery
- (2016) Thomas G. Davies et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
- (2016) Meng-Chen Lu et al. MEDICINAL RESEARCH REVIEWS
- Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
- (2016) Tatsuro Iso et al. MOLECULAR AND CELLULAR BIOLOGY
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
- (2016) Duncan E. Scott et al. NATURE REVIEWS DRUG DISCOVERY
- Twenty years on: the impact of fragments on drug discovery
- (2016) Daniel A. Erlanson et al. NATURE REVIEWS DRUG DISCOVERY
- Kidney epithelium specific deletion of kelch-like ECH-associated protein 1 (Keap1) causes hydronephrosis in mice
- (2016) Sanjeev Noel et al. BMC Nephrology
- p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
- (2016) Tetsuya Saito et al. Nature Communications
- Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
- (2015) B.G. Richardson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors
- (2015) Chunquan Sheng et al. CHEMICAL SOCIETY REVIEWS
- Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators
- (2015) Atul D. Jain et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP
- (2015) Antonio Cuadrado FREE RADICAL BIOLOGY AND MEDICINE
- Structural basis of Keap1 interactions with Nrf2
- (2015) Peter Canning et al. FREE RADICAL BIOLOGY AND MEDICINE
- How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets
- (2015) Bradley C. Doak et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor
- (2015) Zheng-Yu Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
- (2015) Ryota Saito et al. MOLECULAR AND CELLULAR BIOLOGY
- Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
- (2015) Dhulfiqar Ali Abed et al. Acta Pharmaceutica Sinica B
- Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl
- (2014) Melanie P. Chin et al. AMERICAN JOURNAL OF NEPHROLOGY
- Monitoring Keap1–Nrf2 interactions in single live cells
- (2014) Liam Baird et al. BIOTECHNOLOGY ADVANCES
- Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex
- (2014) Eric Jnoff et al. ChemMedChem
- ROS Function in Redox Signaling and Oxidative Stress
- (2014) Michael Schieber et al. CURRENT BIOLOGY
- Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
- (2014) T. Wu et al. GENES & DEVELOPMENT
- Risk Factors for Heart Failure in Patients With Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated With Bardoxolone Methyl
- (2014) Melanie P. Chin et al. JOURNAL OF CARDIAC FAILURE
- Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis
- (2014) Zheng-Yu Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- How proteins bind macrocycles
- (2014) Elizabeth A Villar et al. Nature Chemical Biology
- Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
- (2014) Anne Cleasby et al. PLoS One
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
- (2014) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
- (2013) Douglas Marcotte et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction
- (2013) Longqin Hu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Free Radicals and Antioxidants: How to Reestablish Redox Homeostasis in Chronic Diseases?
- (2013) V. Bocci et al. CURRENT MEDICINAL CHEMISTRY
- Oxidative stress in carcinogenesis: new synthetic compounds with dual effects upon free radicals and cancer.
- (2013) Betul Tekiner-Gulbas et al. CURRENT MEDICINAL CHEMISTRY
- Regulation of Nrf2—an update
- (2013) Suryakant K. Niture et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative Stress and Neurodegenerative Disorders
- (2013) Jie Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?
- (2013) Fabrizio Giordanetto et al. JOURNAL OF MEDICINAL CHEMISTRY
- Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase
- (2013) Mohammad T Elnakish et al. JOURNAL OF PATHOLOGY
- Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1
- (2013) Toshiaki Fukutomi et al. MOLECULAR AND CELLULAR BIOLOGY
- Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
- (2013) Yoshinobu Ichimura et al. MOLECULAR CELL
- Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation
- (2013) Zheng-Yu Jiang et al. PLoS One
- Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
- (2013) L. Baird et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation
- (2012) Holly K. Bryan et al. BIOCHEMICAL PHARMACOLOGY
- Macrocycles in new drug discovery
- (2012) Jamie Mallinson et al. Future Medicinal Chemistry
- Oxidative Stress Promotes Hypertension and Albuminuria During the Autoimmune Disease Systemic Lupus Erythematosus
- (2012) Keisa W. Mathis et al. HYPERTENSION
- PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function
- (2012) J. Ma et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
- (2012) S Chowdhry et al. ONCOGENE
- Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
- (2011) Ana I. Rojo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells
- (2011) Vineet Kumar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Redox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular disease
- (2010) Jeffrey R. Koenitzer et al. Annals of the New York Academy of Sciences
- Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview
- (2010) Ken Itoh et al. ANTIOXIDANTS & REDOX SIGNALING
- Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases
- (2010) Nicole F. Villeneuve et al. ANTIOXIDANTS & REDOX SIGNALING
- Ionizing Radiation Activates the Nrf2 Antioxidant Response
- (2010) J. T. McDonald et al. CANCER RESEARCH
- Fragment-Based Deconstruction of Bcl-xLInhibitors
- (2010) Sarah Barelier et al. JOURNAL OF MEDICINAL CHEMISTRY
- Metals, oxidative stress and neurodegenerative disorders
- (2010) Klaudia Jomova et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
- (2010) T. Ogura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
- (2009) Aimee L. Eggler et al. BIOCHEMICAL JOURNAL
- The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
- (2008) M. Kobayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- Reconciling the chemistry and biology of reactive oxygen species
- (2008) Christine C Winterbourn Nature Chemical Biology
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