Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase

Myocardial Rac1 Exhibits Partial Involvement in Thyroxin-induced Cardiomyocyte Hypertrophy and Its Inhibition Is Not Sufficient to Improve Cardiac Dysfunction or Contractile Abnormalities in Mouse Papillary Muscles

(2013) Mohammad T. Elnakish et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury

(2012) M. A. Hassan Talukder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways

(2012) Jian Ma et al.   CARDIOVASCULAR RESEARCH

Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets

(2012) Lisa de las Fuentes et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Oxidative Stress Causes Mineralocorticoid Receptor Activation in Rat Cardiomyocytes

(2012) Miki Nagase et al.   HYPERTENSION

Rac1 Is a Possible Link Between Obesity and Oxidative Stress in Chinese Overweight Adolescents

(2012) Mingxiao Sun et al.   Obesity

Rac-Induced Left Ventricular Dilation in Thyroxin-Treated ZmRacD Transgenic Mice: Role of Cardiomyocyte Apoptosis and Myocardial Fibrosis

(2012) Mohammad T. Elnakish et al.   PLoS One

Cardiac remodeling caused by transgenic overexpression of a corn Rac gene

(2011) Mohammad T. Elnakish et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation

(2011) Ismail Syed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Friendly, and not so friendly, roles of Rac1 in islet β-cell function: Lessons learnt from pharmacological and molecular biological approaches

(2011) Anjaneyulu Kowluru   BIOCHEMICAL PHARMACOLOGY

Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling

(2011) M.-E. Worou et al.   CARDIOVASCULAR RESEARCH

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets

(2011) Ismail Syed et al.   DIABETES

Augmented NADPH oxidase activity and p22phox expression in monocytes underlie oxidative stress of patients with type 2 diabetes mellitus

(2011) Xiuqing Huang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits

(2011) Hiroshi Ohkawara et al.   Journal of Atherosclerosis and Thrombosis

Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1

(2010) Wasanthi Subasinghe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic β-cells

(2010) Ismail Syed et al.   BIOCHEMICAL PHARMACOLOGY

Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling

(2010) Jan-Christian Reil et al.   CARDIOVASCULAR RESEARCH

Novel aspects of the roles of Rac1 GTPase in the cardiovascular system

(2010) Naoki Sawada et al.   CURRENT OPINION IN PHARMACOLOGY

Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes

(2010) Jianmin Li et al.   DIABETES

Disruption of Rac1 signaling reduces ischemia–reperfusion injury in the diabetic heart by inhibiting calpain

(2010) Limei Shan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rac1 activation induces tumour necrosis factor-α expression and cardiac dysfunction in endotoxemia

(2010) Ting Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Involvement of NADPH oxidase in age-associated cardiac remodeling

(2010) Mingyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rac1-Induced Connective Tissue Growth Factor Regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation

(2010) Oliver Adam et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque

(2010) Suman Dwivedi et al.   Journal of Translational Medicine

Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia

(2009) E. Shen et al.   DIABETES

Association of NAD(P)H Oxidase with Glucose-Induced Insulin Secretion by Pancreatic β-Cells

(2009) D. Morgan et al.   ENDOCRINOLOGY

Pressure-Induced Vascular Oxidative Stress Is Mediated Through Activation of Integrin-Linked Kinase 1/βPIX/Rac-1 Pathway

(2009) Carmine Vecchione et al.   HYPERTENSION

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

Angiotensin II Activates Signal Transducer and Activators of Transcription 3 via Rac1 in Atrial Myocytes and Fibroblasts

(2008) Chia-Ti Tsai et al.   CIRCULATION

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac

(2008) Balakrishnan Selvakumar et al.   FEBS LETTERS

Small GTP-binding proteins and their regulators in cardiac hypertrophy

(2008) Frank Lezoualc'h et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Aldosterone in salt-sensitive hypertension and metabolic syndrome

(2008) Toshiro Fujita   JOURNAL OF MOLECULAR MEDICINE-JMM

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE