Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds
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Title
Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 1, Pages 199
Publisher
MDPI AG
Online
2022-12-23
DOI
10.3390/ijms24010199
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Note: Only part of the references are listed.- Protective role of wogonin following traumatic brain injury by reducing oxidative stress and apoptosis via the PI3K/Nrf2/HO‑1 pathway
- (2022) Yan Feng et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Oridonin ameliorates traumatic brain injury-induced neurological damage by improving mitochondrial function and antioxidant capacity and suppressing neuroinflammation through the Nrf2 pathway
- (2022) Xiao-Jing Zhao et al. JOURNAL OF NEUROTRAUMA
- Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury
- (2022) Yuqin Mao et al. Oxidative Medicine and Cellular Longevity
- Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment
- (2022) Vismitha Rajeev et al. Theranostics
- Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury
- (2022) Riaz Ahmad et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Rutaecarpine Attenuates Oxidative Stress-Induced Traumatic Brain Injury and Reduces Secondary Injury via the PGK1/KEAP1/NRF2 Signaling Pathway
- (2022) Min Xu et al. Frontiers in Pharmacology
- Notoginsenoside R1 alleviates spinal cord injury by inhibiting oxidative stress, neuronal apoptosis, and inflammation via activating the nuclear factor erythroid 2 related factor 2/heme oxygenase-1 signaling pathway
- (2022) Hongbo Luo et al. NEUROREPORT
- Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options
- (2022) Tianqi Jiang et al. Frontiers in Aging Neuroscience
- Evodiamine prevents traumatic brain injury through inhibiting oxidative stress via PGK1/NRF2 pathway
- (2022) Min Xu et al. BIOMEDICINE & PHARMACOTHERAPY
- Effect of Nrf2 signaling pathway on the improvement of intestinal epithelial barrier dysfunction by hyperbaric oxygen treatment after spinal cord injury
- (2021) Xuehua Liu et al. CELL STRESS & CHAPERONES
- Luteolin Modulates the NF-E2-Related Factor 2/Glutamate–Cysteine Ligase Pathway in Rats with Spinal Cord Injury
- (2021) Jian Fu et al. JOURNAL OF MEDICINAL FOOD
- Elevated Heme Oxygenase-1 Correlates With Increased Brain Iron Deposition Measured by Quantitative Susceptibility Mapping and Decreased Hemoglobin in Patients With Parkinson’s Disease
- (2021) Jinghui Xu et al. Frontiers in Aging Neuroscience
- Perillaldehyde Alleviates Spinal Cord Ischemia-Reperfusion Injury Via Activating the Nrf2 Pathway
- (2021) Wenjun Zheng et al. JOURNAL OF SURGICAL RESEARCH
- Ginsenoside Rg1 inhibits oxidative stress and inflammation in rats with spinal cord injury via Nrf2/HO-1 signaling pathway
- (2021) Zhen Zhang et al. NEUROREPORT
- Sodium aescinate provides neuroprotection in experimental traumatic brain injury via the Nrf2-ARE pathway
- (2020) Li Zhang et al. BRAIN RESEARCH BULLETIN
- Tannic Acid Provides Neuroprotective Effects Against Traumatic Brain Injury Through the PGC-1α/Nrf2/HO-1 Pathway
- (2020) Mohd. Salman et al. MOLECULAR NEUROBIOLOGY
- NRF2, a Transcription Factor for Stress Response and Beyond
- (2020) Feng He et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury
- (2020) Han Wang et al. Journal of Neuroinflammation
- Brainstem iron overload and injury in a rat model of brainstem hemorrhage
- (2020) Xi Guo et al. Journal of Stroke & Cerebrovascular Diseases
- Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways
- (2020) Zhanjun Ma et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms
- (2020) Anam Anjum et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury
- (2020) Sicheng Tang et al. Frontiers in Cellular Neuroscience
- Chronic Neurobehavioral Impairments and Decreased Hippocampal Expression of Genes Important for Brain Glucose Utilization in a Mouse Model of Mild TBI
- (2020) Linda M. Huynh et al. Frontiers in Endocrinology
- Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions
- (2020) Abbas Jarrahi et al. Biomedicines
- Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice
- (2020) Xiang‐Sheng Zhang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
- (2019) Antonio Cuadrado et al. NATURE REVIEWS DRUG DISCOVERY
- Sinomenine Attenuates Traumatic Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation via Nrf2 Pathway
- (2019) Lilian Zhang et al. NEUROCHEMICAL RESEARCH
- Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis
- (2019) MirHojjat Khorasanizadeh et al. JOURNAL OF NEUROSURGERY-SPINE
- Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways
- (2019) Artem P. Gureev et al. Frontiers in Genetics
- Breviscapine provides a neuroprotective effect after traumatic brain injury by modulating the Nrf2 signaling pathway
- (2019) Fayin Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds
- (2019) Hiroyuki Katoh et al. Frontiers in Cellular Neuroscience
- Maltol (3-Hydroxy-2-methyl-4-pyrone) Slows d-Galactose-Induced Brain Aging Process by Damping the Nrf2/HO-1-Mediated Oxidative Stress in Mice
- (2019) Ji-yue Sha et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury
- (2019) Meiyu Han et al. Drug Design Development and Therapy
- A review of the pharmacology and toxicology of aucubin
- (2019) Xiangchang Zeng et al. FITOTERAPIA
- Curcumin provides neuroprotection in model of traumatic brain injury via the Nrf2-ARE signaling pathway
- (2018) Wei Dai et al. BRAIN RESEARCH BULLETIN
- Neuroprotective Effects of Luteolin Against Spinal Cord Ischemia–Reperfusion Injury by Attenuation of Oxidative Stress, Inflammation, and Apoptosis
- (2018) Jian Fu et al. JOURNAL OF MEDICINAL FOOD
- Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway
- (2018) Li Zhang et al. NEUROCHEMISTRY INTERNATIONAL
- The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
- (2018) Masayuki Yamamoto et al. PHYSIOLOGICAL REVIEWS
- The Biology of Regeneration Failure and Success After Spinal Cord Injury
- (2018) Amanda Phuong Tran et al. PHYSIOLOGICAL REVIEWS
- Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling
- (2018) Wenwen Dong et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway
- (2018) Qiongyuan Hu et al. Cell Death & Disease
- Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters
- (2018) Zhenyan Hou et al. Frontiers in Pharmacology
- Mulberrin (Mul) reduces spinal cord injury (SCI)-induced apoptosis, inflammation and oxidative stress in rats via miroRNA-337 by targeting Nrf-2
- (2018) Peng Xia et al. BIOMEDICINE & PHARMACOTHERAPY
- Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
- (2018) Jiang Fang et al. Drug Design Development and Therapy
- Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway
- (2018) Runxiao Lv et al. LIFE SCIENCES
- Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury in mice
- (2018) Berrak Caglayan et al. MOLECULAR BIOLOGY REPORTS
- Isoliquiritigenin Provides Protection and Attenuates Oxidative Stress-Induced Injuries via the Nrf2-ARE Signaling Pathway After Traumatic Brain Injury
- (2018) Man Zhang et al. NEUROCHEMICAL RESEARCH
- NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches
- (2018) Farzane Sivandzade et al. Redox Biology
- Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation
- (2017) Liping Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets
- (2017) Ramona E. von Leden et al. JOURNAL OF NEUROTRAUMA
- Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury
- (2017) Zhengrong Mei et al. METABOLIC BRAIN DISEASE
- Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
- (2017) Qing-jie Xia et al. Neural Regeneration Research
- Traumatic Spinal Cord Injury—Repair and Regeneration
- (2017) Christopher S. Ahuja et al. NEUROSURGERY
- Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice
- (2016) Mingkun Zhang et al. BMC NEUROSCIENCE
- MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis
- (2016) Bo Wang et al. Clinical Laboratory
- Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling
- (2016) Jun-Li Zhen et al. EPILEPSY & BEHAVIOR
- Cerebroprotection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways
- (2016) Tian Cheng et al. FREE RADICAL BIOLOGY AND MEDICINE
- Aescin reduces oxidative stress and provides neuroprotection in experimental traumatic spinal cord injury
- (2016) Peng Cheng et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity
- (2016) Tiffany Greco et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- (−)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling Pathways
- (2016) Xi Lan et al. MOLECULAR NEUROBIOLOGY
- Modulation of Behavioral Deficits and Neurodegeneration by Tannic Acid in Experimental Stroke Challenged Wistar Rats
- (2016) Mohammad Ashafaq et al. MOLECULAR NEUROBIOLOGY
- Time representation of mitochondrial morphology and function after acute spinal cord injury
- (2016) Gang Lv et al. Neural Regeneration Research
- Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide
- (2016) X. C. Zheng et al. POULTRY SCIENCE
- Emerging Roles for the Immune System in Traumatic Brain Injury
- (2016) Celia A. McKee et al. Frontiers in Immunology
- Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3
- (2015) John D. Hayes et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
- (2015) Joanna D. Wardyn et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Nrf2 regulates ROS production by mitochondria and NADPH oxidase
- (2015) Stjepana Kovac et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Total antioxidant capacity is associated with mortality of patients with severe traumatic brain injury
- (2015) Leonardo Lorente et al. BMC Neurology
- Fisetin alleviates early brain injury following experimental subarachnoid hemorrhage in rats possibly by suppressing TLR 4/NF-κB signaling pathway
- (2015) Chen-hui Zhou et al. BRAIN RESEARCH
- Luteolin as an anti-inflammatory and neuroprotective agent: A brief review
- (2015) Seyed Fazel Nabavi et al. BRAIN RESEARCH BULLETIN
- Applications of the Keap1–Nrf2 system for gene and cell therapy
- (2015) Katja M. Kanninen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Structural basis of Keap1 interactions with Nrf2
- (2015) Peter Canning et al. FREE RADICAL BIOLOGY AND MEDICINE
- The emerging role of Nrf2 in mitochondrial function
- (2015) Albena T. Dinkova-Kostova et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nrf2—a therapeutic target for the treatment of neurodegenerative diseases
- (2015) Delinda A. Johnson et al. FREE RADICAL BIOLOGY AND MEDICINE
- Neuroprotective effects of pretreatment of ginsenoside Rb1 on severe cerebral ischemia-induced injuries in aged mice: Involvement of anti-oxidant signaling
- (2015) Xiao Dong et al. Geriatrics & Gerontology International
- Nrf2 Activation in Astrocytes Contributes to Spinal Cord Ischemic Tolerance Induced by Hyperbaric Oxygen Preconditioning
- (2014) Jiajun Xu et al. JOURNAL OF NEUROTRAUMA
- Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A cells
- (2014) Hadi Ghaffari et al. LIFE SCIENCES
- Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings
- (2014) Ibrahim Jalloh et al. METABOLIC BRAIN DISEASE
- Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage
- (2014) Zhao Yang et al. MOLECULAR IMMUNOLOGY
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
- (2014) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy
- (2014) Mónika Lippai et al. Biomed Research International
- The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders
- (2014) Pamela J. Urrutia et al. Frontiers in Pharmacology
- (-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways
- (2014) Che-Feng Chang et al. Annals of Clinical and Translational Neurology
- RXR Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
- (2013) H. Wang et al. CANCER RESEARCH
- MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis
- (2013) B. Singh et al. CARCINOGENESIS
- The emerging role of the Nrf2-Keap1 signaling pathway in cancer
- (2013) M. C. Jaramillo et al. GENES & DEVELOPMENT
- Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling
- (2013) N. Wakabayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
- (2013) L. Baird et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
- (2013) K. M. Holmstrom et al. Biology Open
- The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
- (2013) Emilia Kansanen et al. Redox Biology
- Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy
- (2013) Veera Ganesh Yerra et al. Redox Biology
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- Disruptions in the Regulation of Extracellular Glutamate by Neurons and Glia in the Rat Striatum Two Days after Diffuse Brain Injury
- (2012) Jason M. Hinzman et al. JOURNAL OF NEUROTRAUMA
- Spinal cord trauma and the molecular point of no return
- (2012) Ping K Yip et al. Molecular Neurodegeneration
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
- (2012) S Chowdhry et al. ONCOGENE
- Understanding Secondary Injury
- (2012) Richard Ben Borgens et al. QUARTERLY REVIEW OF BIOLOGY
- MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
- (2011) Muhua Yang et al. BREAST CANCER RESEARCH AND TREATMENT
- Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels
- (2011) Wen-Ning Wu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Calcium and cell death mechanisms: A perspective from the cell death community
- (2011) Boris Zhivotovsky et al. CELL CALCIUM
- Signal transduction by reactive oxygen species
- (2011) Toren Finkel JOURNAL OF CELL BIOLOGY
- Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage
- (2011) Gang Chen et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
- (2011) Na Li et al. MECHANISMS OF AGEING AND DEVELOPMENT
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Neuroprotective effect of baicalin on compression spinal cord injury in rats
- (2010) Yang Cao et al. BRAIN RESEARCH
- Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver
- (2010) Soo Han Bae et al. HEPATOLOGY
- CR6-interacting Factor 1 (CRIF1) Regulates NF-E2-related Factor 2 (NRF2) Protein Stability by Proteasome-mediated Degradation
- (2010) Hyo Jin Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae
- (2010) Jian-Ping Yuan et al. MOLECULAR NUTRITION & FOOD RESEARCH
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts
- (2010) Insa M.A. Ernst et al. PHARMACOLOGICAL RESEARCH
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- (2010) M. McMahon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori
- (2009) Zuofa Zhang et al. FITOTERAPIA
- Traumatic brain injury in the United States: an epidemiologic overview
- (2009) Carl R. Summers et al. MOUNT SINAI JOURNAL OF MEDICINE
- Causes and consequences of microRNA dysregulation in cancer
- (2009) Carlo M. Croce NATURE REVIEWS GENETICS
- Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1
- (2008) Claude A. Piantadosi et al. CIRCULATION RESEARCH
- Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
- (2008) C.J. Harvey et al. FREE RADICAL BIOLOGY AND MEDICINE
- Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
- (2008) Patrick L. Apopa et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Activation of Nrf2–ARE pathway in brain after traumatic brain injury
- (2008) Wei Yan et al. NEUROSCIENCE LETTERS
- Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon
- (2008) James W. Rowland et al. Neurosurgical Focus
- Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury
- (2007) Dustin J. Donnelly et al. EXPERIMENTAL NEUROLOGY
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