Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation

Chemistry and Biology of the Ubiquitin Signal

(2012) Liat Spasser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

(2012) Hui Tian et al.   CANCER LETTERS

Protein-protein Docking and Hot-spot Prediction for Drug Discovery

(2012) Solene Grosdidier et al.   CURRENT PHARMACEUTICAL DESIGN

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibitory kappa B kinases as targets for pharmacological regulation

(2011) Carly Gamble et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer

(2011) Kelsie L. Thu et al.   Journal of Thoracic Oncology

Crystal structure of inhibitor of κB kinase β

(2011) Guozhou Xu et al.   NATURE

INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

(2010) S K Niture et al.   CELL DEATH AND DIFFERENTIATION

Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation

(2010) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Critical Role of Nitric Oxide Signaling, via ProteinS-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

(2010) Shigemoto Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP

(2009) Yifeng Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recent Progress and Future Directions in Protein-Protein Docking

(2008) David Ritchie   CURRENT PROTEIN & PEPTIDE SCIENCE

Homology Modeling of Dissimilatory APS Reductases (AprBA) of Sulfur-Oxidizing and Sulfate-Reducing Prokaryotes

(2008) Birte Meyer et al.   PLoS One

Principles of flexible protein-protein docking

(2008) Nelly Andrusier et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation