TCR Pathway Mutations in Mature T Cell Lymphomas

Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma

(2022) Jose R. Cortes et al.   Cell Reports

Investigation of product derived lymphoma following infusion of piggyBac modified CD19 chimeric antigen receptor T-cells

(2021) Kenneth Paul Micklethwaite et al.   BLOOD

Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy

(2021) Andrew Kent et al.   Frontiers in Immunology

BACH2 is a putative T cell lymphoma tumor suppressor that may play a role in product-derived CAR-T cell lymphomas

(2021) Jay Daniels et al.   BLOOD

Integrated Genomic Analyses of Cutaneous T Cell Lymphomas Reveal the Molecular Bases for Disease Heterogeneity

(2021) Joonhee Park et al.   BLOOD

TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma

(2021) Cunte Chen et al.   Cancer Cell International

ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis

(2021) Yuan Qian et al.   Cell Reports

Whole-genome landscape of adult T-cell leukemia/lymphoma

(2021) Yasunori Kogure et al.   BLOOD

Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis

(2021) Javier Robles‐Valero et al.   EMBO JOURNAL

PLCγ1/PKCθ Downstream Signaling Controls Cutaneous T-Cell Lymphoma Development and Progression

(2021) Nuria García-Díaz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Origin of the Functional Distinctiveness of NF-κB/p52

(2021) Gourisankar Ghosh et al.   Frontiers in Cell and Developmental Biology

EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells

(2020) Pablo Lindner et al.   Cell Death & Disease

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

(2020) Yang Liu et al.   EBioMedicine

Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

(2020) Jeong-Ryul Hwang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Role of PD-1 in Acute and Chronic Infection

(2020) Jil M. Jubel et al.   Frontiers in Immunology

Biology and Molecular Pathogenesis of Mature T-Cell Lymphomas

(2020) José R. Cortés et al.   Cold Spring Harbor Perspectives in Medicine

A Novel Pathogenic Variant in CARMIL2 (RLTPR) Causing CARMIL2 Deficiency and EBV-Associated Smooth Muscle Tumors

(2020) Jennifer R. Yonkof et al.   Frontiers in Immunology

Critical protein-protein interactions within the CARMA1-BCL10-MALT1 complex: Take-home points for the cell biologist

(2020) Jing Cheng et al.   CELLULAR IMMUNOLOGY

Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling

(2019) Yosaku Watatani et al.   LEUKEMIA

trackViewer: a Bioconductor package for interactive and integrative visualization of multi-omics data

(2019) Jianhong Ou et al.   NATURE METHODS

Frequent and persistent PLCG1 mutations in Sézary cells directly enhance PLCγ1 activity and stimulate NFκB, AP-1 and NFAT signaling. Short title: Gain-of-function PLCG1 mutations in Sézary Syndrome

(2019) Varsha M. Patel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Reproducing the Molecular Subclassification of Peripheral T-cell Lymphoma-NOS by Immunohistochemistry

(2019) Catalina Amador et al.   BLOOD

Structural basis of assembly of the human T cell receptor–CD3 complex

(2019) De Dong et al.   NATURE

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

(2019) Nicole Hajicek et al.   eLife

Novel insights into the pathogenesis of T-cell lymphomas

(2018) John S. Van Arnam et al.   BLOOD

RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis

(2018) Jose R. Cortes et al.   CANCER CELL

An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia

(2018) Mathew A. Cherian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma

(2018) Nikolai Schleussner et al.   LEUKEMIA

Rapid Progression of Adult T-Cell Leukemia–Lymphoma after PD-1 Inhibitor Therapy

(2018) Lee Ratner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome

(2018) Liron David et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

(2018) Jacquelyn R. Bedsaul et al.   Frontiers in Immunology

Naïve/Memory T-Cell Phenotypes in Leukemic Cutaneous T-Cell Lymphoma: Putative Cell of Origin Overlaps Disease Classification

(2018) Pedro Horna et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sézary syndrome

(2018) Elisabetta Caprini et al.   Cell Death & Disease

The roles of ZEB1 in tumorigenic progression and epigenetic modifications

(2018) Yu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma

(2017) M Fujisawa et al.   LEUKEMIA

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

(2017) Tim Wartewig et al.   NATURE

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

(2017) Francesco Abate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

(2017) Marek Wieczorek et al.   Frontiers in Immunology

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma

(2016) R. L. Boddicker et al.   BLOOD

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas

(2016) D. Vallois et al.   BLOOD

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells

(2016) Romain Roncagalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape

(2016) Mikolai Fajer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

T-Cell Lymphoma: Recent Advances in Characterization and New Opportunities for Treatment

(2016) Carla Casulo et al.   JNCI-Journal of the National Cancer Institute

Peripheral T-cell lymphomas of follicular helper T-cell type frequently display an aberrant CD3−/dimCD4+ population by flow cytometry: an important clue to the diagnosis of a Hodgkin lymphoma mimic

(2016) Mir Alikhan et al.   MODERN PATHOLOGY

BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

(2016) Rahul Roychoudhuri et al.   NATURE IMMUNOLOGY

Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism

(2016) Justus Mahnke et al.   Scientific Reports

T-Cell Lymphoma: Recent Advances in Characterization and New Opportunities for Treatment

(2016) Carla Casulo et al.   JNCI-Journal of the National Cancer Institute

Variegated RHOA mutations in adult T-cell leukemia/lymphoma

(2015) Y. Nagata et al.   BLOOD

Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation

(2015) Sujan Devkota et al.   JOURNAL OF MOLECULAR BIOLOGY

Recurrent activating mutations of CD28 in peripheral T-cell lymphomas

(2015) J Rohr et al.   LEUKEMIA

Genomic landscape of cutaneous T cell lymphoma

(2015) Jaehyuk Choi et al.   NATURE GENETICS

The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome

(2015) Ana Carolina da Silva Almeida et al.   NATURE GENETICS

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

(2015) Mark J. Kiel et al.   Nature Communications

PKC-Theta in Regulatory and Effector T-cell Functions

(2015) Vedran Brezar et al.   Frontiers in Immunology

Cytotoxic T-cell and NK-cell Lymphomas

(2014) Steven H. Swerdlow et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

PLCG1 mutations in cutaneous T-cell lymphomas

(2014) José P. Vaqué et al.   BLOOD

Cellular origin of T-cell lymphomas

(2014) L. de Leval et al.   BLOOD

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

(2014) J. Iqbal et al.   BLOOD

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

The C-Terminal SH3 Domain Contributes to the Intramolecular Inhibition of Vav Family Proteins

(2014) M. Barreira et al.   Science Signaling

Dysfunction of phospholipase Cγ in immune disorders and cancer

(2014) Hans Koss et al.   TRENDS IN BIOCHEMICAL SCIENCES

Personalized treatment of Sézary syndrome by targeting a novelCTLA4:CD28fusion

(2014) Aleksandar Sekulic et al.   Molecular Genetics & Genomic Medicine

TH2 Cytokines from Malignant Cells Suppress TH1 Responses and Enforce a Global TH2 Bias in Leukemic Cutaneous T-cell Lymphoma

(2013) E. Guenova et al.   CLINICAL CANCER RESEARCH

The Role of CARMA1 in T Cells

(2013) Marly I. Roche et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Locking the Active Conformation of c-Src Kinase through the Phosphorylation of the Activation Loop

(2013) Yilin Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

Regulation of NF-κB signaling by the A20 deubiquitinase

(2012) Noula Shembade et al.   Cellular & Molecular Immunology

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

(2012) Tom D. Bunney et al.   STRUCTURE

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

(2011) Ali Aghdassi et al.   GUT

Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sézary syndrome

(2011) F C M Braun et al.   LEUKEMIA

Protein Kinase C Regulation: C1 Meets C-tail

(2011) Marcelo G. Kazanietz et al.   STRUCTURE

Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

(2010) Lynn Verstrepen et al.   BIOCHEMICAL PHARMACOLOGY

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

(2010) Konstanze Pechloff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-β1-mediated growth suppression in adult T-cell leukemia/lymphoma

(2010) S Nakahata et al.   ONCOGENE

NPM-ALK Oncogenic Tyrosine Kinase Controls T-Cell Identity by Transcriptional Regulation and Epigenetic Silencing in Lymphoma Cells

(2009) C. Ambrogio et al.   CANCER RESEARCH

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

The structure, regulation, and function of ZAP-70

(2009) Byron B. Au-Yeung et al.   IMMUNOLOGICAL REVIEWS

The Lymphoma-associated Fusion Tyrosine Kinase ITK-SYK Requires Pleckstrin Homology Domain-mediated Membrane Localization for Activation and Cellular Transformation

(2009) Sue Rigby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival

(2009) Nicolas Bidère et al.   NATURE

A Structural Guide to Proteins of the NF- B Signaling Module

(2009) T. Huxford et al.   Cold Spring Harbor Perspectives in Biology

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Structure and Clinical Relevance of the Epidermal Growth Factor Receptor in Human Cancer

(2008) Amit Kumar et al.   JOURNAL OF CLINICAL ONCOLOGY

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA