The Role of PD-1 in Acute and Chronic Infection

Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection

(2019) Loryn Holokai et al.   PLoS Pathogens

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

(2019) Rémi Fromentin et al.   Nature Communications

Expression of programmed cell death protein 1 and T‐cell immunoglobulin‐ and mucin‐domain‐containing molecule‐3 on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus infection and in subjects who spontaneously cleared the virus

(2019) Kamila Caraballo Cortés et al.   JOURNAL OF VIRAL HEPATITIS

The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance

(2019) Günther Schönrich et al.   Frontiers in Cellular and Infection Microbiology

CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

(2019) Yuejiao Dong et al.   BMC IMMUNOLOGY

Checkpoint Inhibition and Infectious Diseases: A Good Thing?

(2019) Michael S. Abers et al.   TRENDS IN MOLECULAR MEDICINE

Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade

(2019) Bailin Niu et al.   Frontiers in Immunology

Reactivation of tuberculosis in cancer patients following administration of immune checkpoint inhibitors: current evidence and clinical practice recommendations

(2019) Amalia Anastasopoulou et al.   Journal for ImmunoTherapy of Cancer

PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani

(2018) Samar Habib et al.   INFECTION AND IMMUNITY

Inhibitors of the PD-1 Pathway in Tumor Therapy

(2018) Martin W. LaFleur et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function

(2018) Peter T. Sage et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages

(2018) Jason D. Yang et al.   PLoS Pathogens

Programmed Cell Death Protein 1–PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection

(2018) Raíssa Fonseca et al.   Frontiers in Immunology

Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again

(2018) Samantha L. Bucktrout et al.   Genome Medicine

PD-1 and PD-L1 regulate cellular immunity in canine visceral leishmaniasis

(2018) Kathlenn Liezbeth Oliveira Silva et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection

(2017) Jeffrey E. Teigler et al.   JOURNAL OF VIROLOGY

Proportions of circulating follicular helper T cells are reduced and correlate with memory B cells in HIV-infected children

(2017) Daniel M. Muema et al.   PLoS One

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A

(2016) Hyosun Cho et al.   Gut and Liver

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4 + T Cell Immunity

(2016) Deshapriya S. Karunarathne et al.   IMMUNITY

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

(2016) John Attanasio et al.   IMMUNITY

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

(2016) Frank A. Schildberg et al.   IMMUNITY

Reinventing HCV Treatment: Past and Future Perspectives

(2016) Wendy Carter et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Multiple Inhibitory Pathways Contribute to Lung CD8+T Cell Impairment and Protect against Immunopathology during Acute Viral Respiratory Infection

(2016) John J. Erickson et al.   JOURNAL OF IMMUNOLOGY

CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade

(2016) Zong-Sheng Tang et al.   Molecular Medicine Reports

Unique human immune signature of Ebola virus disease in Guinea

(2016) Paula Ruibal et al.   NATURE

The characteristic profiles of PD-1 and PD-L1 expressions and dynamic changes during treatment in active tuberculosis

(2016) Lei Shen et al.   TUBERCULOSIS

Role of Tim-3 in hepatitis B virus infection: An overview

(2016) Yuan Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Longitudinal characterization of dysfunctional T cell-activation during human acute Ebola infection

(2016) C Agrati et al.   Cell Death & Disease

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART

(2016) Rémi Fromentin et al.   PLoS Pathogens

Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis

(2015) Hai-Ning Chen et al.   Gastric Cancer

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1 Suppresses Protective Immunity toStreptococcus pneumoniaethrough a B Cell–Intrinsic Mechanism

(2015) Jerome T. McKay et al.   JOURNAL OF IMMUNOLOGY

Programmed Death-1 Controls T Cell Survival by Regulating Oxidative Metabolism

(2015) Victor Tkachev et al.   JOURNAL OF IMMUNOLOGY

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia

(2015) Cristina Peligero et al.   PLoS Pathogens

Treatment of Hepatitis C

(2014) Anita Kohli et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High-Programmed Death-1 Levels on Hepatitis C Virus-Specific T Cells during Acute Infection Are Associated with Viral Persistence and Require Preservation of Cognate Antigen during Chronic Infection

(2014) A. Rutebemberwa et al.   JOURNAL OF IMMUNOLOGY

Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis

(2014) M. Lafon et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Direct Recognition of Infected Cells by CD4 T Cells Is Required for Control of Intracellular Mycobacterium tuberculosis In Vivo

(2013) S. Srivastava et al.   JOURNAL OF IMMUNOLOGY

Parasite-Derived Arginase Influences Secondary Anti-Leishmania Immunity by Regulating Programmed Cell Death-1-Mediated CD4+ T Cell Exhaustion

(2013) Z. Mou et al.   JOURNAL OF IMMUNOLOGY

Programmed Death 1-Mediated T Cell Exhaustion during Visceral Leishmaniasis Impairs Phagocyte Function

(2013) K. J. Esch et al.   JOURNAL OF IMMUNOLOGY

Local Blockade of Epithelial PDL-1 in the Airways Enhances T Cell Function and Viral Clearance during Influenza Virus Infection

(2013) Beth McNally et al.   JOURNAL OF VIROLOGY

Inadequate T follicular cell help impairs B cell immunity during HIV infection

(2013) Rafael A Cubas et al.   NATURE MEDICINE

A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection

(2013) David Gardiner et al.   PLoS One

B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade

(2013) Katherine J. Nicholas et al.   PLoS One

PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

(2013) Edward Seung et al.   PLoS One

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

(2012) John J. Erickson et al.   JOURNAL OF CLINICAL INVESTIGATION

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

(2012) Helge Frebel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vivo Blockade of the PD-1 Receptor Suppresses HIV-1 Viral Loads and Improves CD4+ T Cell Levels in Humanized Mice

(2012) B. E. Palmer et al.   JOURNAL OF IMMUNOLOGY

Role of PD-L1/PD-1 in the immune response to respiratory viral infections

(2012) Mihnea Tudor Zdrenghea et al.   MICROBES AND INFECTION

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

The Role of Coinhibitory Signaling Pathways in Transplantation and Tolerance

(2012) Martina M. McGrath et al.   Frontiers in Immunology

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

(2011) F. Porichis et al.   BLOOD

Expression of CD25highRegulatory T Cells and PD-1 in Gastric Infiltrating CD4+T Lymphocytes in Patients with Helicobacter pylori Infection

(2011) Yi-Ying Wu et al.   Clinical and Vaccine Immunology

Programmed Death 1 Regulates Development of Central Memory CD8 T Cells after Acute Viral Infection

(2011) S. R. Allie et al.   JOURNAL OF IMMUNOLOGY

IFN-  Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity

(2011) S. Terawaki et al.   JOURNAL OF IMMUNOLOGY

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

(2011) Noah S Butler et al.   NATURE IMMUNOLOGY

Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade

(2011) R. Bhadra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased programmed death-ligand-1 expression in human gastric epithelial cells in Helicobacter pylori infection

(2010) Y.-Y. Wu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of PD-1 in regulating acute infections

(2010) Keturah E Brown et al.   CURRENT OPINION IN IMMUNOLOGY

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1-Mediated Inhibition

(2010) D. L. Barber et al.   JOURNAL OF IMMUNOLOGY

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

(2010) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

PD-1 on dendritic cells impedes innate immunity against bacterial infection

(2009) S. Yao et al.   BLOOD

Negative T-cell costimulatory pathways: their role in regulating alloimmune responses

(2009) Olaf Boenisch et al.   Current Opinion in Organ Transplantation

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

(2009) Paola Fisicaro et al.   GASTROENTEROLOGY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells

(2009) Marion Pepper et al.   NATURE IMMUNOLOGY

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C

(2009) Juan Ramón Larrubia et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

(2008) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Dynamic Programmed Death 1 Expression by Virus-Specific CD8 T Cells Correlates With the Outcome of Acute Hepatitis B

(2008) Zheng Zhang et al.   GASTROENTEROLOGY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Programmed death-1 expression is associated with the disease status in hepatitis B virus infection

(2008) Pian Ye et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients

(2007) Guoping Peng et al.   MOLECULAR IMMUNOLOGY