ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis

Fedratinib in myelofibrosis

(2020) Ann Mullally et al.   Blood Advances

Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome

(2019) Paulo S. Silveira-Mattos et al.   Scientific Reports

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

(2019) Jonathan J. Cho et al.   Nature Communications

ZEBs: Novel Players in Immune Cell Development and Function

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Single-Cell RNA-Seq Technologies and Related Computational Data Analysis

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RRAS2 shapes the TCR repertoire by setting the threshold for negative selection

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A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

(2019)   Nature Communications

Opposing T cell responses in experimental autoimmune encephalomyelitis

(2019) Naresha Saligrama et al.   NATURE

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

(2019) Roxsan Manshouri et al.   Nature Communications

Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system

(2019) Shailesh K. Shahi et al.   Scientific Reports

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1

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ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+T cell fates

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Targeting the GM-CSF receptor for the treatment of CNS autoimmunity

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Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets

(2017) Difeng Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions

(2017) Chih-Hung Chou et al.   NUCLEIC ACIDS RESEARCH

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation

(2017) Subhash K. Tripathi et al.   Cell Reports

Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severity

(2017) Keren Regev et al.   JAMA Neurology

Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell–Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis

(2016) Igal Ifergan et al.   JOURNAL OF IMMUNOLOGY

Dicer and microRNA expression in multiple sclerosis and response to interferon therapy

(2016) William J. Magner et al.   JOURNAL OF NEUROIMMUNOLOGY

Structural basis for DNA recognition by STAT6

(2016) Jing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An atlas of mouse CD4+ T cell transcriptomes

(2015) Michael JT Stubbington et al.   Biology Direct

Genomic landscape of cutaneous T cell lymphoma

(2015) Jaehyuk Choi et al.   NATURE GENETICS

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

(2015) Michele W L Teng et al.   NATURE MEDICINE

DIANA-miRGen v3.0: accurate characterization of microRNA promoters and their regulators

(2015) Georgios Georgakilas et al.   NUCLEIC ACIDS RESEARCH

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

(2015) Yonghao Cao et al.   Science Translational Medicine

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation

(2015) Jeong-Hwan Yoon et al.   Nature Communications

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Cre recombinase induces DNA damage and tetraploidy in the absence ofLoxPsites

(2014) Vaibhao Janbandhu et al.   CELL CYCLE

miR-101 Promotes Breast Cancer Cell Apoptosis by Targeting Janus Kinase 2

(2014) Lu Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

JAK2-STAT3 Blockade by AG490 Suppresses Autoimmune Arthritis in Mice via Reciprocal Regulation of Regulatory T Cells and Th17 Cells

(2014) J.-S. Park et al.   JOURNAL OF IMMUNOLOGY

SLAM–SAP Signaling Promotes Differentiation of IL-17–Producing T Cells and Progression of Experimental Autoimmune Encephalomyelitis

(2014) Yu-Hsuan Huang et al.   JOURNAL OF IMMUNOLOGY

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

(2014) Felix J. Hartmann et al.   Nature Communications

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

(2014) Michelle A Linterman et al.   eLife

TH2 Cytokines from Malignant Cells Suppress TH1 Responses and Enforce a Global TH2 Bias in Leukemic Cutaneous T-cell Lymphoma

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Dynamic regulatory network controlling TH17 cell differentiation

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Th17 Cells in Multiple Sclerosis Express Higher Levels of JAK2, Which Increases Their Surface Expression of IFN- R2

(2012) L. Conti et al.   JOURNAL OF IMMUNOLOGY

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

(2012) Francisco J Quintana et al.   NATURE IMMUNOLOGY

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

(2012) C. N. Arnold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

(2011) Luyan Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades

(2011) Marc R. Friedländer et al.   NUCLEIC ACIDS RESEARCH

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2

(2010) Ling Ding et al.   CELL RESEARCH

Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma

(2009) A. Navarro et al.   BLOOD

Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT2

(2009) A. Y. Higashi et al.   JOURNAL OF IMMUNOLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH