EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells

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De novo variants in SETD1B are associated with intellectual disability, epilepsy and autism

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Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2

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Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma

(2017) Pablo García-Sanz et al.   INTERNATIONAL JOURNAL OF CANCER

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

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A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer

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Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells

(2016) Shinjiro Hino et al.   CANCER SCIENCE

Epigenetic regulation of epithelial–mesenchymal transition

(2016) Lidong Sun et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability

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Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

(2016) Silvia Juliana Serrano-Gomez et al.   Molecular Cancer

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

(2016) Waltraut Lehmann et al.   Nature Communications

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

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DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

(2015) Min-Hyung Cho et al.   Nature Communications

Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability

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Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer

(2014) Chirine El-Baba et al.   Molecular Cancer

Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis

(2014) Yongqing Liu et al.   Nature Communications

Targeting TBP-Associated Factors in Ovarian Cancer

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Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype

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A p21-ZEB1 Complex Inhibits Epithelial-Mesenchymal Transition through the MicroRNA 183-96-182 Cluster

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Dynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1

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Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells

(2012) Cornel J Phillip et al.   BMC CANCER

MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB

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SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

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The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer

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Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

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Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

(2011) Stefan Enroth et al.   BMC CANCER

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

(2011) Ali Aghdassi et al.   GUT

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1

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(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

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