Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

(2019) Lorenza Magno et al.   Alzheimers Research & Therapy

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells

(2018) Geoffrey Guittard et al.   Scientific Reports

Phospholipase C-gamma 2 activity in familial steroid-sensitive nephrotic syndrome

(2018) Limor Parker et al.   PEDIATRIC RESEARCH

A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes

(2017) Weigang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

(2017) Katrina M de Lange et al.   NATURE GENETICS

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy

(2017) Dan A. Landau et al.   Nature Communications

The Phospholipase Cγ2Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein

(2016) Claudia Walliser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ

(2016) Zhifeng Huang et al.   MOLECULAR CELL

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

(2016) Jan A. Burger et al.   Nature Communications

Hierarchical nanostructure and synergy of multimolecular signalling complexes

(2016) Eilon Sherman et al.   Nature Communications

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Genomic landscape of cutaneous T cell lymphoma

(2015) Jaehyuk Choi et al.   NATURE GENETICS

The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome

(2015) Ana Carolina da Silva Almeida et al.   NATURE GENETICS

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

(2015) Mark J. Kiel et al.   Nature Communications

PLCG1 mutations in cutaneous T-cell lymphomas

(2014) José P. Vaqué et al.   BLOOD

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway

(2014) Sreeja B. Asokan et al.   DEVELOPMENTAL CELL

Membrane-induced Allosteric Control of Phospholipase C-β Isozymes

(2014) Thomas H. Charpentier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome

(2014) R. A. Gbadegesin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

(2014) Sam Behjati et al.   NATURE GENETICS

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

(2014) Zahra Timsah et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

(2014) Jennifer A. Woyach et al.   NEW ENGLAND JOURNAL OF MEDICINE

The autoinhibitory C-terminal SH2 domain of phospholipase C- 2 stabilizes B cell receptor signalosome assembly

(2014) J. Wang et al.   Science Signaling

Dysfunction of phospholipase Cγ in immune disorders and cancer

(2014) Hans Koss et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes

(2013) Nicole Hajicek et al.   BIOCHEMISTRY

A Hypermorphic Missense Mutation in PLCG2 , Encoding Phospholipase Cγ2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

(2012) Qing Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mammalian Phospholipase C

(2012) Ganesh Kadamur et al.   Annual Review of Physiology

Structural Basis for Calcium and Phosphatidylserine Regulation of Phospholipase C δ1

(2012) Jon W. Lomasney et al.   BIOCHEMISTRY

Vav1 Oncogenic Mutation Inhibits T Cell Receptor-induced Calcium Mobilization through Inhibition of Phospholipase Cγ1 Activation

(2012) Mira Knyazhitsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

(2012) Levi C.T. Pierce et al.   Journal of Chemical Theory and Computation

LAT-Independent Erk Activation via Bam32-PLC-γ1-Pak1 Complexes: GTPase-Independent Pak1 Activation

(2012) Alexandre K. Rouquette-Jazdanian et al.   MOLECULAR CELL

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Cold Urticaria, Immunodeficiency, and Autoimmunity Related toPLCG2Deletions

(2012) Michael J. Ombrello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

(2012) Tom D. Bunney et al.   STRUCTURE

Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase C 2

(2011) K. L. Everett et al.   MOLECULAR AND CELLULAR BIOLOGY

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

(2011) Angeline M Lyon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Fluorogenic, Small Molecule Reporter for Mammalian Phospholipase C Isozymes

(2010) Weigang Huang et al.   ACS Chemical Biology

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

(2010) Aurelie Gresset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Scaffolding Mediated by a Phospholipase C-  and Gq Signaling Complex

(2010) G. L. Waldo et al.   SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site

(2009) Jae Hyun Bae et al.   CELL

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

(2009) Katy L. Everett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Rac Regulates Its Effector Phospholipase Cγ2through Interaction with a Split Pleckstrin Homology Domain

(2008) Claudia Walliser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL