The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells

Dual T cell– and B cell–intrinsic deficiency in humans with biallelicRLTPRmutations

(2016) Yi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells

(2016) Monica Macal et al.   JOURNAL OF IMMUNOLOGY

Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2

(2015) M. Hunter Lanier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif

(2015) Cheryl H. Rozanski et al.   JOURNAL OF IMMUNOLOGY

CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formation

(2015) M. Hunter Lanier et al.   MOLECULAR BIOLOGY OF THE CELL

The cytotoxic T cell proteome and its shaping by the kinase mTOR

(2015) Jens L Hukelmann et al.   NATURE IMMUNOLOGY

Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor

(2015) Ruijun Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K

(2014) Kunitake Higo et al.   IMMUNOLOGICAL INVESTIGATIONS

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

(2014) Qian Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

Integrative biology of T cell activation

(2014) Bernard Malissen et al.   NATURE IMMUNOLOGY

Capping protein regulators fine-tune actin assembly dynamics

(2014) Marc Edwards et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

(2013) Ying Xim Tan et al.   NATURE IMMUNOLOGY

The lymphoid lineage–specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

(2013) Yinming Liang et al.   NATURE IMMUNOLOGY

CARMIL leading edge localization depends on a non-canonical PH domain and dimerization

(2013) Adam Zwolak et al.   Nature Communications

Regulation of NF-κB by the CARD proteins

(2012) Changying Jiang et al.   IMMUNOLOGICAL REVIEWS

Mechanism for CARMIL Protein Inhibition of Heterodimeric Actin-capping Protein

(2012) Taekyung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1–HSP90

(2012) Dennis J. Eastburn et al.   JOURNAL OF CELL SCIENCE

CD28 Promotes CD4+ T Cell Clonal Expansion during Infection Independently of Its YMNM and PYAP Motifs

(2012) A. J. Pagan et al.   JOURNAL OF IMMUNOLOGY

Regulation of PKC-θ function by phosphorylation in T cell receptor signaling

(2012) Xiaohong Wang et al.   Frontiers in Immunology

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

(2011) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

NF-κB Activation in T Cells Requires Discrete Control of IκB Kinase α/β (IKKα/β) Phosphorylation and IKKγ Ubiquitination by the ADAP Adapter Protein

(2010) Rupa Srivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: CD28 and c-Rel-Dependent Pathways Initiate Regulatory T Cell Development

(2010) K. B. Vang et al.   JOURNAL OF IMMUNOLOGY

Structural characterization of a capping protein interaction motif defines a family of actin filament regulators

(2010) Maria Hernandez-Valladares et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antigen Receptor Signaling to NF- B via CARMA1, BCL10, and MALT1

(2010) M. Thome et al.   Cold Spring Harbor Perspectives in Biology

Maturation of mouse NK cells is a 4-stage developmental program

(2009) L. Chiossone et al.   BLOOD

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor

(2009) Michael Mingueneau et al.   IMMUNITY

Direct Observation of the Uncapping of Capping Protein-capped Actin Filaments by CARMIL Homology Domain 3

(2009) Ikuko Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

(2009) L. F. Dodson et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomere Protection by TPP1 Is Mediated by POT1a and POT1b

(2009) T. Kibe et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Roles for CARMIL Isoforms in Cell Migration

(2009) Yun Liang et al.   MOLECULAR BIOLOGY OF THE CELL

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

(2009) Stephen J Pettitt et al.   NATURE METHODS

The HSP90-SGT1 Chaperone Complex for NLR Immune Sensors

(2008) Ken Shirasu   Annual Review of Plant Biology

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY