Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

Modulation of Pore Opening of Eukaryotic Sodium Channels by π-Helices in S6

(2023) Koushik Choudhury et al.   Journal of Physical Chemistry Letters

Structural mapping of Nav1.7 antagonists

(2023) Qiurong Wu et al.   Nature Communications

P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models

(2022) Denis B. Tikhonov et al.   Membranes

High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV

(2022) Gaoxingyu Huang et al.   Cell Reports

Structural basis for NaV1.7 inhibition by pore blockers

(2022) Jiangtao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target

(2022) Chelsea A. Crossley et al.   Computational and Structural Biotechnology Journal

Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs

(2021) Denis B. Tikhonov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine

(2021) Koushik Choudhury et al.   BIOPHYSICAL JOURNAL

Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds**

(2020) Shuai Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel

(2019) Yanyu Zhao et al.   CELL

Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels

(2019) William A. Catterall et al.   Annual Review of Pharmacology and Toxicology

The role of π-helices in TRP channel gating

(2019) Lejla Zubcevic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cryo-EM structures of apo and antagonist-bound human Cav3.1

(2019) Yanyu Zhao et al.   NATURE

Structure and gating mechanism of the transient receptor potential channel TRPV3

(2018) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational ensemble of the human TRPV3 ion channel

(2018) Lejla Zubcevic et al.   Nature Communications

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

(2017) Denis B. Tikhonov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

(2016) Lin Tang et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 complex

(2015) J. Wu et al.   SCIENCE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function

(2010) Daniel P. Garden et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structural Model for Dihydropyridine Binding to L-type Calcium Channels

(2009) Denis B. Tikhonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY