Flow Chamber Analyses in Cardiovascular Research: Impact of Platelets and the Intercellular Crosstalk with Endothelial Cells, Leukocytes, and Red Blood Cells

Ex vivo observation of granulocyte activity during thrombus formation

(2022) Daria S. Morozova et al.   BMC BIOLOGY

Pannexin-1 Activation by Phosphorylation Is Crucial for Platelet Aggregation and Thrombus Formation

(2022) Lisa Maria Metz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

(2022) Stefano Navarro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CLEC-2 supports platelet aggregation in mouse but not human blood at arterial shear

(2022) Joshua Bourne et al.   THROMBOSIS AND HAEMOSTASIS

β-Amyloid promotes platelet activation and activated platelets act as bridge between risk factors and Alzheimer’s disease

(2022) Tao-Ran Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner

(2021) Henrike Hoermann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation

(2021) Stefano Navarro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reelin Amplifies GPVI Activation and Alphaiib Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases

(2020) Irena Krueger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid

(2020) Lili Donner et al.   Science Signaling

Efficiently restored thrombopoietin production via AMR and IL‐6R induced JAK2‐STAT3 signaling early after partial hepatectomy

(2020) Friedrich Reusswig et al.   HEPATOLOGY

Extracellular DNA NET-Works With Dire Consequences for Health

(2019) Nicoletta Sorvillo et al.   CIRCULATION RESEARCH

Phospholipase D1 regulation of TNF-alpha protects against responses to LPS

(2018) Marc-Andre Urbahn et al.   Scientific Reports

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis

(2018) Christoph Klatt et al.   JOURNAL OF CLINICAL INVESTIGATION

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

(2018) Constance C. F. M. J. Baaten et al.   BLOOD

Store-operated calcium entry in thrombosis and thrombo-inflammation

(2018) Elmina Mammadova-Bach et al.   CELL CALCIUM

Platelet biology and functions: new concepts and clinical perspectives

(2018) Paola E. J. van der Meijden et al.   Nature Reviews Cardiology

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and LeukocytesSignificance

(2016) Norbert Gerdes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of leukocytes in thrombosis

(2016) Laura L. Swystun et al.   BLOOD

Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease

(2016) Ilaria Canobbio et al.   CELLULAR SIGNALLING

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

RhoGAPs and Rho GTPases in platelets

(2015) M. Elvers   Hamostaseologie

Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice

(2015) A. Fotinos et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Src family kinases: at the forefront of platelet activation

(2014) Y. A. Senis et al.   BLOOD

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease

(2014) Andrea Jarre et al.   CELLULAR SIGNALLING

Platelet Activation and Platelet-leukocyte Aggregation Elicited in Experimental Colitis Are Mediated by Interleukin-6

(2014) Serena L.S. Yan et al.   INFLAMMATORY BOWEL DISEASES

Blood Platelets in the Progression of Alzheimer’s Disease

(2014) Nina S. Gowert et al.   PLoS One

Dynamic adhesion of eryptotic erythrocytes to immobilized platelets via platelet phosphatidylserine receptors

(2013) Britta Walker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Combined In Vivo Depletion of Glycoprotein VI and C-Type Lectin-Like Receptor 2 Severely Compromises Hemostasis and Abrogates Arterial Thrombosis in Mice

(2013) Markus Bender et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation

(2013) Patrick Münzer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

The role of the red cell membrane in thrombin generation

(2013) Matthew F. Whelihan et al.   THROMBOSIS RESEARCH

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intracellular cyclophilin A is an important Ca2+ regulator in platelets and critically involved in arterial thrombus formation

(2012) M. Elvers et al.   BLOOD

Redundant functions of phospholipases D1 and D2 in platelet α-granule release

(2012) I. THIELMANN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Lytic Resistance of Fibrin Containing Red Blood Cells

(2011) Nikolett Wohner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes

(2011) O. Borst et al.   BLOOD

Platelet and Soluble Glycoprotein VI - Novel Applications in Diagnosis and Therapy

(2011) Boris Bigalke et al.   CURRENT DRUG TARGETS

Collagen surfaces to measure thrombus formation under flow: possibilities for standardization

(2011) J. W. M. HEEMSKERK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Procoagulant and prothrombotic activation of human erythrocytes by phosphatidic acid

(2010) Ji-Yoon Noh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets

(2010) I. Pleines et al.   BLOOD

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet receptor signaling in thrombus formation

(2010) David Stegner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cγ2

(2010) M. ELVERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired  IIb 3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

(2010) M. Elvers et al.   Science Signaling

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation

(2009) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Integrins in platelet activation

(2009) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes

(2009) Kathryn Gersh et al.   THROMBOSIS AND HAEMOSTASIS

Cell Adhesion Mechanisms in Platelets

(2008) David Varga-Szabo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

(2008) David Varga-Szabo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple ways to switch platelet integrins on and off

(2008) J. M. E. M. COSEMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rac1 is essential for phospholipase C-γ2 activation in platelets

(2008) Irina Pleines et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY