β-Amyloid promotes platelet activation and activated platelets act as bridge between risk factors and Alzheimer’s disease

Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

(2021) Renato S. Gaspar et al.   Scientific Reports

Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models

(2021) Tong Wu et al.   Aging-US

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

(2021) Yingxi Wu et al.   Acta Neuropathologica Communications

High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation

(2021) Min Wang et al.   Alzheimers Research & Therapy

Can platelet activation result in increased plasma Aβ levels and contribute to the pathogenesis of Alzheimer’s disease?

(2021) Manuel Glauco Carbone et al.   AGEING RESEARCH REVIEWS

Platelets in Amyloidogenic Mice Are Activated and Invade the Brain

(2020) Kathrin M. Kniewallner et al.   Frontiers in Neuroscience

Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials

(2020) Jin-Tai Yu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Fibrillar amyloid peptides promote platelet aggregation through the coordinated action of itam‐ and ros‐dependent pathways

(2020) Caterina Visconte et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications

(2020) Mikhail Inyushin et al.   Frontiers in Immunology

Amyloid Peptide β1-42 Induces Integrin αIIbβ3 Activation, Platelet Adhesion, and Thrombus Formation in a NADPH Oxidase-Dependent Manner

(2019) Aisha Alsheikh Abubaker et al.   Oxidative Medicine and Cellular Longevity

Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease

(2019) Zdeněk Fišar et al.   CLINICAL BIOCHEMISTRY

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Multivariate Platelet Analysis Differentiates Between Patients with Alzheimer’s Disease and Healthy Controls at First Clinical Diagnosis

(2019) Isabella Wiest et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β as a Blood Biomarker for Alzheimer’s Disease: A Review of Recent Literature

(2019) Xiaoni Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease

(2019) Tao-Ran Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Predictive Value of Routine Peripheral Blood Biomarkers in Alzheimer’s Disease

(2019) Xiaoyu Dong et al.   Frontiers in Aging Neuroscience

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

(2018) Lili Donner et al.   CELLULAR SIGNALLING

Protein levels of ADAM10, BACE1, and PSEN1 in platelets and leukocytes of Alzheimer’s disease patients

(2018) Jessyka Maria de França Bram et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

(2018) N. T. Moldogazieva et al.   FREE RADICAL RESEARCH

Amyloid precursor protein is required for in vitro platelet adhesion to amyloid peptides and potentiation of thrombus formation

(2018) Caterina Visconte et al.   CELLULAR SIGNALLING

Platelet Tau Pattern Correlates with Cognitive Status in Alzheimer's Disease

(2018) Gonzalo Farías et al.   JOURNAL OF ALZHEIMERS DISEASE

Platelets isolated from an Alzheimer mouse damage healthy cortical vessels and cause inflammation in an organotypic ex vivo brain slice model

(2018) Kathrin M. Kniewallner et al.   Scientific Reports

Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies

(2017) X-L Bu et al.   MOLECULAR PSYCHIATRY

Platelet Amyloid Precursor Protein Isoform Expression in Alzheimer's Disease: Evidence for Peripheral Marker

(2017) A. Vignini et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease

(2016) Ilaria Canobbio et al.   CELLULAR SIGNALLING

Protein Expression of BACE1 is Downregulated by Donepezil in Alzheimer’s Disease Platelets

(2016) Tamires Alves Sarno et al.   JOURNAL OF ALZHEIMERS DISEASE

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: Haemostasis, platelet activation and antithrombotic therapy

(2015) Alyssa J. Moroi et al.   BIOCHEMICAL PHARMACOLOGY

Platelet dysfunction in hypercholesterolemia mice, two Alzheimer’s disease mouse models and in human patients with Alzheimer’s disease

(2015) Barbara Plagg et al.   BIOGERONTOLOGY

Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer’s Disease: Baseline Data from a DIAN Cohort Subset

(2015) Pratishtha Chatterjee et al.   Current Alzheimer Research

Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease

(2015) Ilaria Canobbio et al.   Frontiers in Cellular Neuroscience

P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia

(2014) Santosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amyloid β-peptide-dependent activation of human platelets: essential role for Ca2+and ADP in aggregation and thrombus formation

(2014) Ilaria Canobbio et al.   BIOCHEMICAL JOURNAL

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease

(2014) Andrea Jarre et al.   CELLULAR SIGNALLING

Amyloid β peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization

(2014) Vijay K. Sonkar et al.   FASEB JOURNAL

Blood Platelets in the Progression of Alzheimer’s Disease

(2014) Nina S. Gowert et al.   PLoS One

The increase of mean platelet volume in patients with Alzheimer disease

(2014) Emine Rabia KOÇ et al.   Turkish Journal Of Medical Sciences

Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

(2014) Jana Hroudová et al.   Biomed Research International

Molecular mechanisms of platelet P2Y12receptor regulation

(2013) Margaret R. Cunningham et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

(2013) Jon B. Toledo et al.   BRAIN

Prevalence of dementia subtypes in a developing country: a clinicopathological study

(2013) LT Grinberg et al.   Clinics

Platelet-Derived Secreted Amyloid-Precursor Protein-β as a Marker for Diagnosing Alzheimer’s Disease

(2013) Josef Marksteiner et al.   CURRENT NEUROVASCULAR RESEARCH

Immobilized amyloid Aβ peptides support platelet adhesion and activation

(2013) Ilaria Canobbio et al.   FEBS LETTERS

Role of platelets in neurodegenerative diseases: a universal pathophysiology

(2013) Madhuri Behari et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Decreased mean platelet volume and platelet distribution width are associated with mild cognitive impairment and Alzheimer's disease

(2013) Rui-tao Wang et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Processing of the Platelet Amyloid Precursor Protein in the Mild Cognitive Impairment (MCI)

(2013) Paloma Bermejo-Bescós et al.   NEUROCHEMICAL RESEARCH

Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer’s disease

(2013) Qing-Cheng Liang et al.   PLATELETS

P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised

(2013) Petter Järemo et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Reduced platelet amyloid precursor protein ratio (APP ratio) predicts conversion from mild cognitive impairment to Alzheimer’s disease

(2012) Isis A. Zainaghi et al.   JOURNAL OF NEURAL TRANSMISSION

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD)

(2011) Yusuf Yesil et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

The role of mean platelet volume in predicting thrombotic events

(2011) Yucel Colkesen et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: Implications for Alzheimer's disease

(2011) J. Gregor Sutcliffe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia

(2011) B. NAGY JR et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity

(2011) Pedro J Chacon et al.   Molecular Neurodegeneration

Coated-platelet levels and progression from mild cognitive impairment to Alzheimer disease

(2011) C. I. Prodan et al.   NEUROLOGY

Low-density platelet populations demonstrate lowin vivoactivity in sporadic Alzheimer disease

(2011) P. Järemo et al.   PLATELETS

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets

(2010) I. Canobbio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Platelet Alpha- and Beta- Secretase Activities are not Significantly Affected by Dementia or Mild Cognitive Impairment in Swedish Patients

(2010) P. Gorham et al.   Current Alzheimer Research

Predictive Value of Platelet Activation for the Rate of Cognitive Decline in Alzheimer's Disease Patients

(2010) Konstantinos Stellos et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer’s disease

(2010) Orestes V. Forlenza et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Differences in Coated-platelet Production Between Frontotemporal Dementia and Alzheimer Disease

(2009) Calin I. Prodan et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Platelet activation is caused not by aging but by atherosclerosis

(2009) Hitoshi Kurabayashi et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Protein kinase Cε: an oncogene and emerging tumor biomarker

(2009) Michael A Gorin et al.   Molecular Cancer

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

Amyloid beta peptide-activated signal pathways in human platelets

(2008) Ming Y. Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A novel reciprocal and biphasic relationship between membrane cholesterol and β-secretase activity in SH-SY5Y cells and in human platelets

(2008) Wei Wei Liu et al.   JOURNAL OF NEUROCHEMISTRY

Expression of amyloid beta peptide in human platelets: Pivotal role of the phospholipase Cγ2-protein kinase C pathway in platelet activation

(2008) Ming-Yi Shen et al.   PHARMACOLOGICAL RESEARCH

Rate of progression in Alzheimer’s disease correlates with coated-platelet levels—a longitudinal study

(2008) Calin I. Prodan et al.   Translational Research

Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer’s disease

(2007) Christoph Laske et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Platelet β-secretase activity is increased in Alzheimer's disease

(2006) J.A. Johnston et al.   NEUROBIOLOGY OF AGING