The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid

Comparison of the GPVI inhibitors losartan and honokiol

(2019) Marie-Blanche Onselaer et al.   PLATELETS

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

(2018) Lili Donner et al.   CELLULAR SIGNALLING

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

(2018) Alexandre Slater et al.   PLATELETS

Angiotensin IV Receptors Mediate the Cognitive and Cerebrovascular Benefits of Losartan in a Mouse Model of Alzheimer's Disease

(2017) Jessika Royea et al.   JOURNAL OF NEUROSCIENCE

Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI

(2017) O. Elaskalani et al.   PLATELETS

Strategies for dementia prevention: latest evidence and implications

(2017) Gopalkumar Rakesh et al.   Therapeutic Advances in Chronic Disease

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Enalapril Alone or Co-Administered with Losartan Rescues Cerebrovascular Dysfunction, but not Mnemonic Deficits or Amyloidosis in a Mouse Model of Alzheimer’s Disease

(2016) Brice Ongali et al.   JOURNAL OF ALZHEIMERS DISEASE

Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development

(2016) R. H. Lee et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Recent global trends in the prevalence and incidence of dementia, and survival with dementia

(2016) Martin Prince et al.   Alzheimers Research & Therapy

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

(2015) Osama M. Alshehri et al.   BIOCHEMICAL JOURNAL

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

The role of platelets in inflammation

(2015) Robert Storey et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan

(2015) Peng Jiang et al.   PLoS One

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease

(2014) Andrea Jarre et al.   CELLULAR SIGNALLING

The contribution of platelet studies to the understanding of disease mechanisms in complex and monogenetic neurological disorders

(2014) Christophe Goubau et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice

(2014) Hyung Jin Ahn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The functional role of platelets in the regulation of angiogenesis

(2014) Tony G. Walsh et al.   PLATELETS

Blood Platelets in the Progression of Alzheimer’s Disease

(2014) Nina S. Gowert et al.   PLoS One

Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy

(2013) Marta Sochocka et al.   CNS & Neurological Disorders-Drug Targets

Role of platelets in neurodegenerative diseases: a universal pathophysiology

(2013) Madhuri Behari et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice

(2012) Tanja Schönberger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A benchmarked protein microarray-based platform for the identification of novel low-affinity extracellular protein interactions

(2012) Yi Sun et al.   ANALYTICAL BIOCHEMISTRY

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation

(2010) C. Schulz et al.   BLOOD

Predictive Value of Platelet Activation for the Rate of Cognitive Decline in Alzheimer's Disease Patients

(2010) Konstantinos Stellos et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Alzheimer's disease peptide  -amyloid interacts with fibrinogen and induces its oligomerization

(2010) H. J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet α-granules: Basic biology and clinical correlates

(2009) Price Blair et al.   BLOOD REVIEWS

Fibrinogen, a possible key player in Alzheimer’s disease

(2009) M. CORTES-CANTELI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rac1 is essential for phospholipase C-γ2 activation in platelets

(2008) Irina Pleines et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer’s disease

(2007) Christoph Laske et al.   JOURNAL OF PSYCHIATRIC RESEARCH