Platelet biology and functions: new concepts and clinical perspectives

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

(2018) Thomas O. Bergmeijer et al.   AMERICAN HEART JOURNAL

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus StabilityHighlights

(2018) Frédéric Adam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms of platelet clearance and translation to improve platelet storage

(2018) M. Edward Quach et al.   BLOOD

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

(2018) Irina Pleines et al.   BLOOD

Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans

(2018) Kristina Busygina et al.   BLOOD

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

(2018) Milka Koupenova et al.   CIRCULATION RESEARCH

Restenosis, Stent Thrombosis, and Bleeding Complications

(2018) Juan Torrado et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response

(2018) L. Pasalic et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Current and future antiplatelet therapies: emphasis on preserving haemostasis

(2018) James D. McFadyen et al.   Nature Reviews Cardiology

Thromboinflammatory Functions of Platelets in Ischemia–Reperfusion Injury and Its Dysregulation in Diabetes

(2018) Sophie Maiocchi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Issue Information

(2018)   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Introducing high-throughput sequencing into mainstream genetic diagnosis practice in inherited platelet disorders

(2017) José M. Bastida et al.   HAEMATOLOGICA

A new path to platelet production through matrix sensing

(2017) Vittorio Abbonante et al.   HAEMATOLOGICA

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

(2017) Michael J. Kraakman et al.   JOURNAL OF CLINICAL INVESTIGATION

Antiplatelet Agents for the Treatment and Prevention of Coronary Atherothrombosis

(2017) Carlo Patrono et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease

(2017) Rick A. Nishimura et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High-throughput sequencing approaches for diagnosing hereditary bleeding and platelet disorders

(2017) K. Freson et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Matching patients with the ever-expanding range of TAVI devices

(2017) Brandon M. Jones et al.   Nature Reviews Cardiology

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

(2017) John W. Eikelboom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet microvesicles in health and disease

(2017) Imene Melki et al.   PLATELETS

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

(2017) Philipp von Hundelshausen et al.   Science Translational Medicine

The role of RNA uptake in platelet heterogeneity

(2017) Lea Beaulieu et al.   THROMBOSIS AND HAEMOSTASIS

Thrombopoiesis is spatially regulated by the bone marrow vasculature

(2017) David Stegner et al.   Nature Communications

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Introducing high-throughput sequencing into mainstream genetic diagnosis practice in inherited platelet disorders

(2017) José M. Bastida et al.   HAEMATOLOGICA

A new path to platelet production through matrix sensing

(2017) Vittorio Abbonante et al.   HAEMATOLOGICA

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and LeukocytesSignificance

(2016) Norbert Gerdes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear FlowSignificance

(2016) Jevgenia Zilberman-Rudenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Up or out: polarity of VWF release

(2016) R. Bierings et al.   BLOOD

Genomic landscape of megakaryopoiesis and platelet function defects

(2016) E. Bianchi et al.   BLOOD

Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin

(2016) S. Dinkla et al.   BLOOD

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

(2016) J. W. Rowley et al.   BLOOD

Respective contributions of single and compound granule fusion to secretion by activated platelets

(2016) Anita Eckly et al.   BLOOD

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

(2016) I. Simeoni et al.   BLOOD

Inherited platelet disorders: toward DNA-based diagnosis

(2016) C. Lentaigne et al.   BLOOD

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage

(2016) Nadine J. A. Mattheij et al.   FASEB JOURNAL

Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces

(2016) Shu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling

(2016) Daniela Semeniak et al.   JOURNAL OF CELL SCIENCE

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease

(2016) Glenn N. Levine et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Platelet signaling: a complex interplay between inhibitory and activatory networks

(2016) A. P. Bye et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome

(2016) Fiorella A. Solari et al.   MOLECULAR & CELLULAR PROTEOMICS

The role of platelet microvesicles in intercellular communication

(2016) Leonard C. Edelstein   PLATELETS

The nuts and bolts of the platelet release reaction

(2016) Smita Joshi et al.   PLATELETS

Inflammatory Contribution of Platelets Revisited: New Players in the Arena of Inflammation

(2016) Madhumita Chatterjee et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

(2016) Thomas Moreau et al.   Nature Communications

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

(2016) Simone M. Schoenwaelder et al.   Nature Communications

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase  , and Not Via CD40 and I B Kinase  

(2015) M. J. E. Kuijpers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circular RNA enrichment in platelets is a signature of transcriptome degradation

(2015) Abd A. Alhasan et al.   BLOOD

Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome

(2015) A. Sharda et al.   BLOOD

Regulating billions of blood platelets: glycans and beyond

(2015) R. Grozovsky et al.   BLOOD

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

(2015) E. Mammadova-Bach et al.   BLOOD

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

(2015) Myron G. Best et al.   CANCER CELL

Coordinated Membrane Ballooning and Procoagulant Spreading in Human PlateletsClinical Perspective

(2015) Ejaife O. Agbani et al.   CIRCULATION

Coated platelets function in platelet-dependent fibrin formation via integrin α IIb β 3 and transglutaminase factor XIII

(2015) Nadine J.A. Mattheij et al.   HAEMATOLOGICA

Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow

(2015) F. Swieringa et al.   HAEMATOLOGICA

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating primers enhance platelet function and induce resistance to antiplatelet therapy

(2015) T. A. Blair et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antithrombotic therapy for left ventricular assist devices in adults: a systematic review

(2015) L. M. Baumann Kreuziger et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

P2Y12receptors: structure and function

(2015) M. Cattaneo   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Exploration of efficacy and bleeding with combined phosphoinositide 3-kinase β inhibition and aspirin in man

(2015) S. Nylander et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Acute and persistent platelet and coagulant activities in atherothrombosis

(2015) T. G. Mastenbroek et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inherited disorders of platelet function: selected updates

(2015) A. T. Nurden et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

MicroRNAs in platelet function and cardiovascular disease

(2015) David D. McManus et al.   Nature Reviews Cardiology

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

(2015) Anne-Claire Duchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD

(2015) Karin Müller et al.   THROMBOSIS AND HAEMOSTASIS

Microvesicles from platelets: novel drivers of vascular inflammation

(2015) Tanja Vajen et al.   THROMBOSIS AND HAEMOSTASIS

Coated platelets function in platelet-dependent fibrin formation via integrin α IIb β 3 and transglutaminase factor XIII

(2015) Nadine J.A. Mattheij et al.   HAEMATOLOGICA

Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow

(2015) F. Swieringa et al.   HAEMATOLOGICA

Phosphoinositide 3-Kinases p110α and p110β Have Differential Roles in Insulin-Like Growth Factor-1–Mediated Akt Phosphorylation and Platelet Priming

(2014) Thomas A. Blair et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity

(2014) T. J. Stalker et al.   BLOOD

Defective release of   granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

(2014) R. Meng et al.   BLOOD

A tour through the transcriptional landscape of platelets

(2014) S. Schubert et al.   BLOOD

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein

(2014) M. Bender et al.   BLOOD

Targeting platelet receptor function in thrombus formation: The risk of bleeding

(2014) Frauke Swieringa et al.   BLOOD REVIEWS

Platelet Immunoreceptor Tyrosine-Based Activation Motif (ITAM) Signaling and Vascular Integrity

(2014) Yacine Boulaftali et al.   CIRCULATION RESEARCH

Platelet Lipidomics

(2014) Valerie B. O’Donnell et al.   CIRCULATION RESEARCH

Stent Thrombosis

(2014) Bimmer E. Claessen et al.   JACC-Cardiovascular Interventions

Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability

(2014) Ewelina M. Golebiewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome function is required for platelet production

(2014) Dallas S. Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

Aspirin Therapy in Primary Cardiovascular Disease Prevention

(2014) Sigrun Halvorsen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Copy Number Analysis of the Murine Platelet Proteome Spanning the Complete Abundance Range

(2014) Marlis Zeiler et al.   MOLECULAR & CELLULAR PROTEOMICS

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk

(2014) D. Moeckel et al.   Science Translational Medicine

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

(2014) Emma C. Josefsson et al.   Nature Communications

Identification of platelet function defects by multi-parameter assessment of thrombus formation

(2014) Susanne M. de Witt et al.   Nature Communications

Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice

(2013) M. Morowski et al.   BLOOD

Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression

(2013) O. Gidlof et al.   BLOOD

Integrin α 6 β 1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

(2013) Mathieu Schaff et al.   CIRCULATION

The incredible journey: From megakaryocyte development to platelet formation

(2013) Kellie R. Machlus et al.   JOURNAL OF CELL BIOLOGY

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

(2013) Carsten Deppermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention for Non–ST-Segment Elevation Myocardial Infarction

(2013) Jean-Claude Tardif et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Platelet-derived CXCL12 (SDF-1α): basic mechanisms and clinical implications

(2013) M. Chatterjee et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Loci Associated with Platelet Traits and Platelet Disorders

(2013) Natalia Bunimov et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis

(2012) Sakthivel Vaiyapuri et al.   CIRCULATION

Minding the Gaps—and the Junctions, Too

(2012) Lawrence F. Brass et al.   CIRCULATION

Platelet-based coagulation: different populations, different functions

(2012) J. W. M. HEEMSKERK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Biomarkers of platelet activation in acute coronary syndromes

(2012) Patrizia Ferroni et al.   THROMBOSIS AND HAEMOSTASIS

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis

(2011) E. M. Battinelli et al.   BLOOD

Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators

(2011) Marloes R. Tijssen et al.   DEVELOPMENTAL CELL

Ischaemic stroke: a thrombo-inflammatory disease?

(2011) Bernhard Nieswandt et al.   JOURNAL OF PHYSIOLOGY-LONDON

How platelets safeguard vascular integrity

(2011) B. HO-TIN-NOÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

New gene functions in megakaryopoiesis and platelet formation

(2011) Christian Gieger et al.   NATURE

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury

(2011) Béatrice Hechler et al.   THROMBOSIS AND HAEMOSTASIS

Genetic Regulation of Platelet Receptor Expression and Function

(2010) Marlene S. Williams et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Procoagulant platelets: are they necrotic?

(2010) S. P. Jackson et al.   BLOOD

The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: results from the SMILE-Platelets project

(2010) J. D. SNOEP et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

(2010) J. M. E. M. COSEMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Nitric oxide at a glance

(2010) Khalid M. Naseem et al.   PLATELETS

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Dual role of collagen in factor XII-dependent thrombus formation

(2009) P. E. J. van der Meijden et al.   BLOOD

Platelet Dense-Granule Secretion Plays a Critical Role in Thrombosis and Subsequent Vascular Remodeling in Atherosclerotic Mice

(2009) Sarah M. King et al.   CIRCULATION

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model

(2008) M. J. E. KUIJPERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE