The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner

The Total Thrombus Formation (T-TAS) platelet (PL) assay, a novel test that evaluates whole blood platelet thrombus formation under physiological conditions

(2021) K.L. Zheng et al.   PLATELETS

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury

(2019) Chiara Poluzzi et al.   KIDNEY INTERNATIONAL

Small Leucine Rich Proteoglycans (decorin, biglycan and lumican) in cancer

(2019) Sandeep Appunni et al.   CLINICA CHIMICA ACTA

Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin

(2018) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Regulation of platelet activation and thrombus formation by reactive oxygen species

(2018) Jianlin Qiao et al.   Redox Biology

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis

(2018) Christoph Klatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysis

(2018) Rashid Al Ghaithi et al.   PLATELETS

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

(2017) N. S. Poulter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Loss ofBiglycanEnhances Thrombin Generation inApolipoprotein E-Deficient MiceSignificance

(2016) Maria Grandoch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology

(2016) Liliana Schaefer et al.   FEBS Journal

A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia

(2016) Helena Frey et al.   GLYCOCONJUGATE JOURNAL

Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload

(2016) Nadine Beetz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

(2015) Osama M. Alshehri et al.   BIOCHEMICAL JOURNAL

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

Of von Willebrand factor and platelets

(2014) Marijke Bryckaert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

Biglycan

(2012) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Rho GTPases in platelet function

(2012) J. E. ASLAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Proteoglycan Biglycan Enhances Antigen-Specific T Cell Activation Potentially via MyD88 and TRIF Pathways and Triggers Autoimmune Perimyocarditis

(2011) Z. V. Popovic et al.   JOURNAL OF IMMUNOLOGY

Small Leucine-Rich Proteoglycans in Kidney Disease

(2011) L. Schaefer   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A novel automated microchip flow-chamber system to quantitatively evaluate thrombus formation and antithrombotic agents under blood flow conditions

(2011) K. HOSOKAWA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effects of decorin and biglycan on human airway smooth muscle cell adhesion

(2011) Michelle L. D'Antoni et al.   MATRIX BIOLOGY

Extracellular Matrix Proteins in Hemostasis and Thrombosis

(2011) W. Bergmeier et al.   Cold Spring Harbor Perspectives in Biology

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

(2010) Kristin Moreth et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cγ2

(2010) M. ELVERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet Activation by Extracellular Matrix Proteins in Haemostasis and Thrombosis

(2009) Steve Watson   CURRENT PHARMACEUTICAL DESIGN

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction

(2008) D. Westermann et al.   CIRCULATION