Human brain microphysiological systems in the study of neuroinfectious disorders

Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

(2023) July Carolina Romero et al.   Frontiers in Cellular Neuroscience

Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages

(2023) Michael F. Wells et al.   Cell Stem Cell

Human Brain Organoids as Models for Central Nervous System Viral Infection

(2022) Josse A. Depla et al.   Viruses-Basel

Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity

(2022) David Pamies et al.   NEUROBIOLOGY OF DISEASE

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

(2022) Pinar Mesci et al.   PLOS BIOLOGY

Enterovirus D68 Infection in Human Primary Airway and Brain Organoids: No Additional Role for Heparan Sulfate Binding for Neurotropism

(2022) Adithya Sridhar et al.   Microbiology Spectrum

A Human Stem Cell-Derived Neurosensory–Epithelial Circuitry on a Chip to Model Herpes Simplex Virus Reactivation

(2022) Pietro Giuseppe Mazzara et al.   Biomedicines

A Comprehensive Update of Cerebral Organoids between Applications and Challenges

(2022) Xiaodong Li et al.   Oxidative Medicine and Cellular Longevity

Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus

(2022) Niloufar A. Boghdeh et al.   Viruses-Basel

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

(2021) Cheng Wang et al.   Cell Stem Cell

Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip

(2021) Wesley A. Anderson et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Neuroinvasion of SARS-CoV-2 in human and mouse brain

(2021) Eric Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain

(2021) Qinjie Zhou et al.   Science Translational Medicine

Long-term maturation of human cortical organoids matches key early postnatal transitions

(2021) Aaron Gordon et al.   NATURE NEUROSCIENCE

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

(2021) Veronica Krenn et al.   Cell Stem Cell

Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity

(2021) Megan Chesnut et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Applications of Brain Organoids for Infectious Diseases

(2021) Wenqiang Fan et al.   JOURNAL OF MOLECULAR BIOLOGY

Cerebrospinal fluid in COVID-19 neurological complications: Neuroaxonal damage, anti-SARS-Cov2 antibodies but no evidence of cytokine storm

(2021) Maria A. Garcia et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

(2021) Cyrille Mathieu et al.   mBio

Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology

(2021) Ranjie Xu et al.   Stem Cell Reports

Cerebral Organoids Derived from a Parkinson’s Patient Exhibit Unique Pathogenesis from Chikungunya Virus Infection When Compared to a Non-Parkinson’s Patient

(2021) Emily M. Schultz et al.   Pathogens

A simple method to improve the quality and yield of human pluripotent stem cell-derived cerebral organoids

(2021) Mu Seog Choe et al.   Heliyon

Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma

(2021) Swetha J. Sundar et al.   Translational Oncology

Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons

(2021) Durbadal Ojha et al.   Nature Microbiology

Methodologies for Generating Brain Organoids to Model Viral Pathogenesis in the CNS

(2021) Hannah K. Hopkins et al.   Pathogens

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

(2020) Xiali Zhong et al.   Frontiers in Cellular Neuroscience

Standardized GMP-compliant scalable production of human pancreas organoids

(2020) Marta Dossena et al.   Stem Cell Research & Therapy

Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain

(2020) Yoshiaki Tanaka et al.   Cell Reports

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

(2020) Xuyu Qian et al.   Cell Stem Cell

Toxoplasma infection induces microglia‐neuron contact and the loss of perisomatic inhibitory synapses

(2020) Gabriela L. Carrillo et al.   GLIA

Modeling neurological disorders using brain organoids

(2020) Daniel Y. Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hydrogel-based milliwell arrays for standardized and scalable retinal organoid cultures

(2020) S. Decembrini et al.   Scientific Reports

SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

(2020) Laura Pellegrini et al.   Cell Stem Cell

SARS ‐CoV‐2 targets neurons of 3D human brain organoids

(2020) Anand Ramani et al.   EMBO JOURNAL

Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

(2020) Roberta S. dos Reis et al.   Scientific Reports

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

(2020) Josse A. Depla et al.   Molecular Therapy-Methods & Clinical Development

Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem

(2020) David Pamies et al.   iScience

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

(2020) Yuki Miura et al.   NATURE BIOTECHNOLOGY

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

(2019) Simon Plummer et al.   Scientific Reports

Modeling HSV-1 infections in human CNS neuronal cells using two-dimensional and three- dimensional cultures derived from induced pluripotent stem cells

(2019) Leonardo D'Aiuto et al.   JOURNAL OF VIROLOGY

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

(2019) Yangfei Xiang et al.   Cell Stem Cell

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

(2019) Yan-Peng Xu et al.   CELL RESEARCH

Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors

(2019) Ling Liu et al.   CELL DEATH AND DIFFERENTIATION

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

(2019) Hyosung Kim et al.   Stem Cell Reports

Friends Turn Foe—Astrocytes Contribute to Neuronal Damage in NeuroAIDS

(2019) Hriday Shanker Pandey et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids

(2019) Samantha L. Sison et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Compromises Development of Cerebral Organoids

(2019) Rebecca M. Brown et al.   JOURNAL OF VIROLOGY

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

(2019) Paulo Emílio Corrêa Leite et al.   Particle and Fibre Toxicology

Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

(2019) Liqing Song et al.   Scientific Reports

In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment

(2019) Megan Chesnut et al.   Frontiers in Cellular and Infection Microbiology

The Evolving Concept of the Blood Brain Barrier (BBB): From a Single Static Barrier to a Heterogeneous and Dynamic Relay Center

(2019) Andres Villabona-Rueda et al.   Frontiers in Cellular Neuroscience

Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons

(2019) Clayton W. Winkler et al.   Journal of Neuroinflammation

Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids

(2019) Adriana Harbuzariu et al.   Scientific Reports

Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells

(2018) Beatrice Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons

(2018) Halil Tekin et al.   Nature Biomedical Engineering

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

Reply to Simon et al. on “The neurological complications of chikungunya virus: A systematic review”

(2018) Ravi Mehta et al.   REVIEWS IN MEDICAL VIROLOGY

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

(2018) Celina Monteiro Abreu et al.   Frontiers in Microbiology

Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes

(2017) Christine Kunze et al.   GLIA

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Viral vectors for therapy of neurologic diseases

(2017) Sourav R. Choudhury et al.   NEUROPHARMACOLOGY

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

(2017) David Pamies   ALTEX-Alternatives to Animal Experimentation

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Development and functions of the choroid plexus–cerebrospinal fluid system

(2015) Melody P. Lun et al.   NATURE REVIEWS NEUROSCIENCE

Three-Dimensional Neural Spheroid Culture: AnIn VitroModel for Cortical Studies

(2015) Yu-Ting L. Dingle et al.   TISSUE ENGINEERING PART C-METHODS

Astrocyte gp130 Expression Is Critical for the Control of Toxoplasma Encephalitis

(2014) K. Drogemuller et al.   JOURNAL OF IMMUNOLOGY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial activation involvement in neuronal death by Japanese encephalitis virus infection

(2009) C.-J. Chen et al.   JOURNAL OF GENERAL VIROLOGY

Development of human nervous tissue upon differentiation of embryonic stem cells in three-dimensional culture

(2009) Olivier Preynat-Seauve et al.   STEM CELLS

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell