Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures

(2021) Soraya Scuderi et al.   Stem Cell Reports

The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3

(2020) Theodore A. Gobillot et al.   Viruses-Basel

The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival

(2020) Daniel Giraldo et al.   mBio

A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease

(2020) Dana M. Cairns et al.   Science Advances

Herpes Simplex Virus Type 1 Interactions with the Interferon System

(2020) Kevin Danastas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Herpes simplex virus type 1 infection leads to neurodevelopmental disorder-associated neuropathological changes

(2020) Haowen Qiao et al.   PLoS Pathogens

Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology

(2019) Jihoon Kim et al.   Viruses-Basel

Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors

(2019) Ling Liu et al.   CELL DEATH AND DIFFERENTIATION

Spatial transcriptomics coming of age

(2019) Darren J. Burgess   NATURE REVIEWS GENETICS

ChEA3: transcription factor enrichment analysis by orthogonal omics integration

(2019) Alexandra B Keenan et al.   NUCLEIC ACIDS RESEARCH

HSV-1 single cell analysis reveals anti-viral and developmental programs activation in distinct sub-populations

(2019) Nir Drayman et al.   eLife

Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids

(2019) Samantha L. Sison et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Compromises Development of Cerebral Organoids

(2019) Rebecca M. Brown et al.   JOURNAL OF VIROLOGY

The Transcriptional and Protein Profile From Human Infected Neuroprogenitor Cells Is Strongly Correlated to Zika Virus Microcephaly Cytokines Phenotype Evidencing a Persistent Inflammation in the CNS

(2019) Morganna C. Lima et al.   Frontiers in Immunology

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues

(2019) Herring et al.   Cells

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

(2019) Niko Hensel et al.   Journal of Neuroinflammation

Activation of type I interferon antiviral response in human neural stem cells

(2019) Jhao-Yin Lin et al.   Stem Cell Research & Therapy

An Immunocompetent Mouse Model of Zika Virus Infection

(2018) Matthew J. Gorman et al.   Cell Host & Microbe

Prevalence and causes of congenital microcephaly in the absence of a Zika virus outbreak in southern Brazil

(2018) Silvani Herber et al.   Jornal de Pediatria

Imaging organoids: a bright future ahead

(2018) Anne C Rios et al.   NATURE METHODS

Zika: the continuing threat

(2018)   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

(2017) Chunfeng Li et al.   IMMUNITY

Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy

(2017) Margaret A. Honein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Myeloid Dendritic Cells Repress Human Cytomegalovirus Gene Expression and Spread by Releasing Interferon-Unrelated Soluble Antiviral Factors

(2017) Bahram Kasmapour et al.   JOURNAL OF VIROLOGY

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

(2017) Yuchen Qi et al.   NATURE BIOTECHNOLOGY

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Stress-induced unfolded protein response contributes to Zika virus–associated microcephaly

(2017) Ivan Gladwyn-Ng et al.   NATURE NEUROSCIENCE

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Chromatin organization regulates viral egress dynamics

(2017) Vesa Aho et al.   Scientific Reports

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

First estimates of the global and regional incidence of neonatal herpes infection

(2017) Katharine J Looker et al.   Lancet Global Health

Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes

(2016) Cherie T. Ng et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities

(2016) Guo-li Ming et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice

(2016) Cui Li et al.   Cell Stem Cell

Zika virus inhibits type‐I interferon production and downstream signaling

(2016) Anil Kumar et al.   EMBO REPORTS

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Zika virus — reigniting the TORCH

(2016) Carolyn B. Coyne et al.   NATURE REVIEWS MICROBIOLOGY

Zika Virus Infection in Pregnant Women in Rio de Janeiro

(2016) Patrícia Brasil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

(2016) Feiran Zhang et al.   NUCLEIC ACIDS RESEARCH

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome

(2016) Benxia Hu et al.   Scientific Reports

Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects

(2016) Natasha W. Hanners et al.   Cell Reports

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

(2016) Jennifer Paijo et al.   PLoS Pathogens

Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells

(2016) Yannick Simonin et al.   EBioMedicine

Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells

(2016) Bruno S. F. Souza et al.   Scientific Reports

Establishing neural crest identity: a gene regulatory recipe

(2015) M. Simoes-Costa et al.   DEVELOPMENT

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

(2015) Carmem Gottfried et al.   Frontiers in Psychiatry

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

(2014) J. Hatakeyama et al.   DEVELOPMENT

Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells

(2014) Ana J. Chucair-Elliott et al.   GLIA

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression

(2013) Christopher R. Bolen et al.   HEPATOLOGY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

Antiviral Type I and Type III Interferon Responses in the Central Nervous System

(2013) Frédéric Sorgeloos et al.   Viruses-Basel

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Oncolytic HSV-1 Virotherapy: Clinical Experience and Opportunities for Progress

(2012) Balveen Kaur et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Interferon-α (IFNα) neurotoxicity

(2012) Cari Fritz-French et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

(2012) Fabien G. Lafaille et al.   NATURE

Detecting overlapping protein complexes in protein-protein interaction networks

(2012) Tamás Nepusz et al.   NATURE METHODS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS

(2012) David L. Rousso et al.   NEURON

Stochastic Expression of the Interferon-β Gene

(2012) Mingwei Zhao et al.   PLOS BIOLOGY

Role of Specific Innate Immune Responses in Herpes Simplex Virus Infection of the Central Nervous System

(2011) J. P. Wang et al.   JOURNAL OF VIROLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

A Report of Three Cases and Review of Intrauterine Herpes Simplex Virus Infection

(2010) Lucila Marquez et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models

(2010) Yuichiro Watanabe et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention

(2009) M. C.-J. Cheeran et al.   CLINICAL MICROBIOLOGY REVIEWS

Epigenetic Modulation of Gene Expression from Quiescent Herpes Simplex Virus Genomes

(2009) M. W. Ferenczy et al.   JOURNAL OF VIROLOGY